Transcriptional Activation of miR-34a Contributes to p53-Mediated Apoptosis

Reviver submitted, created time 1 year 6 months (www.molecule.org)

"p53 is a potent tumor suppressor, whose biological effects are largely due to its function as a transcriptional regulator. Here researchers report that, in addition to regulating the expression of hundreds of protein-coding genes, p53 also modulates the levels of microRNAs (miRNAs). Specifically, p53 can induce expression of microRNA-34a (miR-34a) in cultured cells as well as in irradiated mice, by binding to a perfect p53 binding site located within the gene that gives rise to miR-34a. Processing of the primary transcript into mature miR-34a involves the excision of a 30 kb intron

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