Krox20–Nab2 Interactions in Myelination

kavin submitted, created time 7 months 2 days (www.jneurosci.org)

To study the mechanisms underlying myelination, Desmazieres et al. produced transgenic mice that express a mutant form of Krox20 that causes congenital hypomyelinating neuropathy in humans: a mutation that causes a single amino acid substitution, which disrupts interaction between Krox20 and its cofactor Nab2. Interactions between Krox20 and Nab2 appear essential for Krox20 function in peripheral myelination, but not in hindbrain patterning.

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Scientists Help Mice Paralyzed by Spinal Injuries Walk Again

Sue Wu submitted, created time 1 year 1 day (www.nature.com)

Scientists said they've learned more about the natural mechanisms that enable mice, humans and other animals regain spinal function after paralyzing spinal cord injuries, according to a study published in this week's edition of the journal Nature Medicine. There was also a writeup in Fox News

(http://www.foxnews.com/story/0,2933,320537,00.html)

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Chronic exposure to 12-O-tetradecanoylphorbol-13-acetate represses sod2 induction in vivo: The negative role of p50

jiangyun submitted, created time 1 year 4 months (carcin.oxfordjournals.org)

We generated transgenic mice expressing human MnSOD promoter- and enhancer-driven luciferase reporter gene and used a non-invasive imaging system to investigate the effects of TPA on MnSOD expression in vivo. Our data indicate that TPA initially activates MnSOD expression, but this positive effect declines after repeated applications.

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Striatal Medium Spiny Neurons Terminate in a Distinct Region in the Lateral Hypothalamic Area and Do Not Directly Innervate Orexin/Hypocretin- or Melanin-Concentrating Hormone-Containing Neurons

annatto submitted, created time 1 year 6 months (www.jneurosci.org)

"Neuronal circuits including medium spiny neurons (MSNs) in the nucleus accumbens (NAc) and melanin-concentrating hormone (MCH)-containing neurons in the lateral hypothalamic area (LHA) are hypothesized to play an important role in hedonic feeding. A reciprocal connection between NAc MSNs and MCH-containing neurons is proposed to form a neuronal circuit that is involved in hedonic feeding. Although NAc MSNs have been shown to receive projection from MCH-containing neurons, it is not known whether MCH-containing neurons in the LHA also receive direct inputs from NAc MSNs

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Molecular Nature of Anomalous L-Type Calcium Channels in Mouse Cerebellar Granule Cells

julie submitted, created time 1 year 8 months (www.jneurosci.org)

"Single-channel analysis revealed the existence of neuronal L-type Ca2+ channels (LTCCs) with fundamentally different gating properties; in addition to LTCCs resembling cardiac channels, LTCCs with anomalous gating were identified in a variety of neurons, including cerebellar granule cells."

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