SRP Keeps Polypeptides Translocation-Competent

kavin submitted, created time 8 months 5 days (www.cell.com)

As we know, SRP is essential for targeting nascent chains to the endoplasmic reticulum, and it delays nascent chain elongation in cell-free translation systems. In this study, authors depleted mammalian cells of SRP14 by expressing mutant versions of the protein lacking the elongation arrest function. And they suggested that SRP can ensure that nascent chains remain translocation competent during the targeting time window dictated by SR. Since SRP-signal sequence affinities vary, the delay may also regulate which proteins are preferentially targeted.

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