Cellular Islet Autoimmunity and Islet Cell Transplantation

jerry submitted, created time 6 months 5 days (www.plosone.org)

Islet cell transplantation can cure type 1 diabetes (T1D), but only a minority of recipients remains insulin–independent in the following years. They tested the hypothesis that allograft rejection and recurrent autoimmunity contribute to this progressive loss of islet allograft function.

Methodology/Principal Findings:
Twenty-one T1D patients received cultured islet cell grafts prepared from multiple donors and transplanted under anti-thymocyte globulin (ATG) induction and tacrolimus plus mycophenolate mofetil (MMF) maintenance immunosuppression

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Stem cell procedure successfully treats amyloidosis patients

bianjie submitted, created time 1 year 6 months (www.eurekalert.org)

Researchers from the Stem Cell Transplant Program and the Amyloid Treatment and Research Program at Boston University Medical Center (BUMC) have found that tandem cycles of high-dose chemotherapy and blood stem cell transplantation can help treat patients with immunoglobulin-light chain (AL) Amyloidosis who did not respond to initial treatment with this method.

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