Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion.

ariel submitted, created time 6 months 2 weeks (cancerres.aacrjournals.org)

Heat shock protein (hsp) 90 is an ATP-dependent molecular chaperone that maintains the active conformation of client oncoproteins in cancer cells. An isoform, hsp90{alpha}, promotes extracellular maturation of matrix metalloproteinase (MMP)-2, involved in tumor invasion and metastasis.Yonghua Yang and partners have found out that reversible hyperacetylation modulates the intracellular and extracellular chaperone function of hsp90, and targeting extracellular hyperacetylated hsp90{alpha} may undermine tumor invasion and metastasis.

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