Articles with the keyword: 
Angiogenesis: Multipotent tumor endothelial cells
sea-maid submitted, created time 2 months 2 weeks (www.nature.com)
New blood vessels are required for the growth of tumours, but tumor blood vessels are poorly formed and dysfunctional. Can the properties of tumor endothelial cells (TECs) help us to understand abnormalities in tumor blood vessel formation? A recent study has shown that TECs isolated from mouse prostate tumors are distinct from normal endothelial cells (ECs): they are multipotent, undergo calcification and can differentiate into cartilage- and bone-like tissues. These properties may contribute to the atypical characteristics of tumour blood vessels 
Blood test can monitor cancer spread
sea-maid submitted, created time 6 months 4 days (www.nature.com)
A new device that can detect minute numbers of tumour cells circulating in the blood of lung cancer patients may one day make monitoring the disease as simple as taking a blood test.
Tumor Cell Metabolism: Cancer's Achilles' Heel
jerry submitted, created time 6 months 3 weeks (www.sciencedirect.com)
In this paper, scientists review the peculiarities of tumor cell metabolism that might be taken advantage of for cancer treatment. Specifically, they discuss the alterations in signal transduction pathways and/or enzymatic machineries that account for metabolic reprogramming of transformed cells.
Breast Tumor Cells Have This Molecular Characterization
jerry submitted, created time 7 months 3 weeks (ajp.amjpathol.org)
A detailed understanding of the assortment of genes that are expressed in breast tumor vessels is needed to facilitate the development of novel, molecularly targeted anti-angiogenic agents for breast cancer therapies.
This research found Of the 1176 genes that were differentially expressed between tumor and normal vascular cells, 55 had a greater than fourfold increase in expression level
Direct Genetic Analysis of Single Cancer Cells for Therapy Selection in Cancer
jerry submitted, created time 7 months 4 weeks (www.cancercell.org)
The increasing use of primary tumors as surrogate markers for prognosis and therapeutic decisions neglects evolutionary aspects of cancer progression.
The reseachers identified chromosome 17q12–21, the region comprising HER2, as the most frequent gain in disseminated tumor cells that were isolated from both ectopic sites when they analyzed single disseminated cancer cells from lymph nodes and bone marrow of 107 consecutive esophageal cancer patients.
Tumor cells share oncogenic receptors
sea-maid submitted, created time 7 months 4 weeks (www.jcb.org)
Mutant receptors made in one tumor cell can be passed to tumor cells lacking them.
In this study, the authors found that glioma cells expressing EGFRvIII transferred this errant receptor to nonexpressing cells via microvesicles--small plasma membrane buds. The microvesicles were produced in abundance by the mutant expressing cells and were widely taken up by receptor-negative cells
Mitochondrial Mutations Make Tumors Spread
jane2007 submitted, created time 9 months 4 days (sciencenow.sciencemag.org)
Why is it that cancer often strikes its final, fatal blow when a tumor spreads to other organs? It's because of the metastasis of mitochondrial DNA mutations.
Reviver submitted, created time 1 year 6 months (www.biomedcentral.com)
"Researchers results indicate that mature Fast DC are functional antigen presenting cells (APCs) capable of inducing primary T-cell responses, and suggest that these cells may be valuable for generation of anti-tumor vaccines. "
Reduction of peritoneal carcinomatosis by intraperitoneal administration of phospholipids in rats
captainclaw submitted, created time 1 year 6 months (www.biomedcentral.com)
"In this animal study intraperitoneal application of phospholipids resulted in reduction of the extent of peritoneal carcinomatosis after intraperitoneal administration of free tumor cells. This effect was exceptionally noticed when the amount of intraperitoneal tumor cells was limited. Consequently, intraperitoneal administration of phospholipids might be effective in reducing peritoneal carcinomatosis after surgery of gastrointestinal tumors in humans."
Reviver submitted, created time 1 year 7 months (mcb.asm.org)
"Aurora A kinase plays an essential role in the proper assembly and function of the mitotic spindle, as its perturbation causes defects in centrosome separation, spindle pole organization, and chromosome congression. Moreover, Aurora A disruption leads to cell death via a mechanism that involves aneuploidy generation. However, the link between the immediate functional consequences of Aurora A inhibition and the development of aneuploidy is not clearly defined
p27kip1: a target for tumor therapies?
captainclaw submitted, created time 1 year 7 months (www.celldiv.com)
"The cyclin kinase inhibitor p27kip1 acts as a potent tumor supressor protein in a variety of human cancers. Its expression levels correlate closely with the overall prognosis of the affected patient and often predict the outcome to different treatment modalities. In contrast to other tumor suppressor proteins p27 expression levels in tumor cells are frequently regulated by ubiquitin dependent proteolysis. Re-expression of p27 in cancer cells therefore does not require gene therapy but can be achieved by interfering with the protein turnover machinery
Tumor Cell-Organ Microenvironment Interactions in the Pathogenesis of Cancer Metastasis
fiona submitted, created time 1 year 7 months (edrv.endojournals.org)
"The process of cancer metastasis is sequential and selective and contains stochastic elements. The growth of metastases represents the endpoint of many lethal events that few tumor cells can survive. Primary tumors consist of multiple subpopulations of cells with heterogeneous metastatic properties, and the outcome of metastasis depends on the interplay of tumor cells with various host factors."
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