p53 Activation: A Case against Sir

jerry submitted, created time 7 months 4 weeks (www.cancercell.org)

The p53 tumor suppressor is a critical transcription factor for controlling cell growth and apoptosis during times of cellular stress.

In this issue, the researchers screened small-molecule activators of p53 that could potentially reduce tumor growth Tenovin-6 was identified as a potent SIRT1 and SIRT2 inhibitor that indirectly activated p53 at single-digit micromolar concentrations.

The identification of a specific sirtuin inhibitor has broad implications in understanding sirtuin-p53 signaling and the development of novel chemotherapeutics

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Adoptively transferred human lung tumor specific cytotoxic T cells can control autologous tumor growth and shape tumor phenotype in a SCID mouse xenograft model

crackpot submitted, created time 1 year 6 months (www.translational-medicine.com)

These studies provide additional information regarding the characteristics of CTLs which can be found within a patients tumor. Moreover, the in vivo model described here can provide a unique window for observing events that may also occur in patients undergoing adoptive cellular immunotherapy as effector cells seek and destroy areas of tumor growth and for testing strategies to improve clinical effectiveness.

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Tumor growth mathematics studied

DanyC submitted, created time 1 year 6 months (www.sciencedaily.com)

A U.S. mathematical study has led researchers to a better understanding of how cancer cells alter their genetic makeup to accelerate tumor growth.

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Mathematics reveals genetic pattern of tumor growth

bioman submitted, created time 1 year 6 months (today.uci.edu)

Using mathematical theory, UC Irvine scientists have shed light on one of cancer’s most troubling puzzles – how cancer cells can alter their own genetic makeup to accelerate tumor growth. The discovery shows for the first time why this change occurs, providing insight into how cancerous tumors thrive and a potential foundation for future cancer treatments.

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CSHL scientists successfully target tumor microenvironment to stop cancer growth

newsdigg submitted, created time 1 year 6 months (www.eurekalert.org)

Cold Spring Harbor Laboratory (CSHL) researchers led by Daniel Nolan and Assistant Professor Vivek Mittal have found that bone marrow (BM) derived endothelial progenitor cells (EPCs) play a critical role in the early stages of tumor progression and that eliminating EPCs stops cancer growth. Using sophisticated high-resolution microscopy and flow cytometry, they zeroed in on the earliest stages of cancer progression and identified the role of EPCs in generating blood vessels that allow cancers to grow

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Study: Nexavar Extends Survival In Liver Cancer Patients

DanyC submitted, created time 1 year 7 months (money.cnn.com)

A study of 602 patients showed those receiving Nexavar had a median overall survival of 10.7 months compared to 7.9 months among patients taking placebo. About half the patients received Nexavar while the other half received placebo, or a fake treatment. Patients in the study had advanced liver cancer that could not be cured by surgery. Researchers said the survival difference translates into a significant 44% survival advantage for patients in the Nexavar group compared to those in the placebo group.

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