The von Hippel–Lindau tumor suppressor protein: O2 sensing and cancer

sea-maid submitted, created time 2 months 2 weeks (www.nature.com)

The von Hippel–Lindau disease is caused by inactivating germline mutations of the VHL tumor suppressor gene and is associated with an increased risk of a variety of tumours in an allele-specific manner. The role of the heterodimeric transcription factor hypoxia-inducible factor (HIF) in the pathogenesis of VHL-defective tumors has been more firmly established during the past five years

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A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell Invasion

dedu submitted, created time 1 year 1 month (www.cell.com)

“Epithelial cells require attachment to extracellular matrix (ECM) to suppress an apoptotic cell death program termed anoikis. Michael et al. describe a nonapoptotic cell death program in matrix-detached cells that is initiated by a previously unrecognized and unusual process involving the invasion of one cell into another, leading to a transient state in which a live cell is contained within a neighboring host cell. Live internalized cells are either degraded by lysosomal enzymes or released

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Induction of Cullin 7 by DNA damage attenuates p53 function

addict submitted, created time 1 year 6 months (www.pnas.org)

The p53 tumor suppressor gene encodes a transcription factor, which is translationally and posttranslationally activated after DNA damage. In a proteomic screen for p53 interactors, we found that the cullin protein Cul7 efficiently associates with p53. After DNA damage, the level of Cul7 protein increased in a caffeine-sensitive, but p53-independent, manner.

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