Articles with the keyword: 
Specific tumor suppressor function for E2F2 in Myc-induced T cell lymphomagenesis
jimmy submitted, created time 1 year 3 months (www.pnas.org)
Deregulation of the Myc pathway and deregulation of the Rb pathway are two of the most common abnormalities in human malignancies. Recent in vitro experiments suggest a complex cross-regulatory relationship between Myc and Rb that is mediated through the control of E2F. 
Study details regulation of vital tumor suppressor gene p53
lewis submitted, created time 1 year 4 months (www.eurekalert.org)
So vital is the p53 tumor suppressor gene in controlling cancer that its dysfunction is linked to more than half of human cancers. Now, a just-published study reveals new levels of subtlety in the body's management of this all-important tumor suppressor gene and the protein it produces.
bianjie submitted, created time 1 year 5 months (www.pnas.org)
INK4a/ARF tumor suppressor locus encodes two protein products, INK4a and ARF, essential for controlling tumorigenesis and mutated in more than half of human cancers.
DanyC submitted, created time 1 year 6 months (www.wjso.com)
A new case of a solitary primitive intracranial leptomeningeal astrocytoma of a rare polycystic variant is reported. Clinical, surgical, pathologic and therapeutic aspects of this tumor are discussed.
The novel PIAS-like protein hZimp10 is a transcriptional co-activator of the p53 tumor suppressor
bioman submitted, created time 1 year 6 months (nar.oxfordjournals.org)
The tumor suppressor, p53, plays critical roles in the cell cycle progression, DNA repair and apoptosis. The PIAS proteins (protein inhibitor of activated STAT) were originally identified as inhibitors of the JAK-STAT pathway. Subsequently, crosstalk between the PIAS proteins and other signaling pathways has been shown to be involved in various cellular processes. Particularly, previous studies have demonstrated that PIAS proteins regulate p53-mediated transcription through sumoylation. hZimp10, also named zmiz1, is a novel PIAS-like protein and functions as a transcriptional co-activator
Captnimbus submitted, created time 1 year 6 months (www.fasebj.org)
Medulloblastoma, the most common brain tumor in childhood, appears to originate from cerebellar granule cell precursors (GCPs), located in the external granular layer (EGL) of the cerebellum. The antiproliferative gene PC3 (Tis21/BTG2) promotes cerebellar neurogenesis by inducing GCPs to shift from proliferation to differentiation
Alzheimer's Enzyme Acts As A Tumor Suppressor
Cindy submitted, created time 1 year 6 months (www.sciencedaily.com)
Researchers at Burnham Institute for Medical Research ("Burnham") have provided the first evidence that gamma-secretase, an enzyme key to the progression of Alzheimer's, acts as a tumor suppressor by altering the pathway of epidermal growth factor receptor (EGFR), a potential treatment target for cancer. Expedited to publication online by Proceedings of the National Academy of Sciences, these findings reveal a limitation of targeting gamma-secretase for treatment of Alzheimer's and potentially other diseases.
Small RNAs, Not Just Proteins, Hold Big Power In Halting Cancer
Dolly submitted, created time 1 year 7 months (www.sciencedaily.com)
Cold Spring Harbor Laboratory (CSHL) researchers led by Lin He, Xingyue He, and Professor and Howard Hughes Medical Investigator (HHMI) Greg Hannon have identified a family of micro RNAs (miRNAs) that enable a critical tumor suppressor network, called the p53 pathway, to fight cancer growth. At CSHL, we are moving simultaneously on several fronts to understand the p53 pathway because damage to this pathway is something that almost all cancers have in common.
Researchers Discover Variants Of Natural Tumor Suppressor
cappuccion submitted, created time 1 year 8 months (www.medicalnewstoday.com)
The new work describes a second family member, PHLPP2, which also inactivates Akt, inhibiting the cell cycle progression and promoting cell death. However, PHLPP1 and PHLPP2 control three different disease pathways. While both are important in cancer, PHLPP 1 impacts an important pathway in diabetes and PHLPP2 could be useful in fighting heart and neurological disease.
High-throughput oncogene mutation profiling in human cancer
nomad submitted, created time 1 year 10 months (www.nature.com)
Systematic efforts are underway to decipher the genetic changes associated with tumor initiation and progression1, 2. However, widespread clinical application of this information is hampered by an inability to identify critical genetic events across the spectrum of human tumors with adequate sensitivity and scalability. Here, we have adapted high-throughput genotyping to query 238 known oncogene mutations across 1,000 human tumor samples. This approach established robust mutation distributions spanning 17 cancer types
Tumor Suppressor Identity Unmasked!
Ranger submitted, created time 1 year 10 months (www.cell.com)
Cancer gene discovery has relied extensively on analyzing tumors for gains and losses to reveal the location of oncogenes and tumor suppressor genes, respectively. Deletions of 1p36 are extremely common genetic lesions in human cancer, occurring in malignancies of epithelial, neural, and hematopoietic origin. Although this suggests that 1p36 harbors a gene that drives tumorigenesis when inactivated, the identity of this tumor suppressor has remained elusive. The team use chromosome engineering to generate mouse models with gain and loss of a region corresponding to human 1p36
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