The von Hippel–Lindau tumor suppressor protein: O2 sensing and cancer

sea-maid submitted, created time 2 months 2 weeks (www.nature.com)

The von Hippel–Lindau disease is caused by inactivating germline mutations of the VHL tumor suppressor gene and is associated with an increased risk of a variety of tumours in an allele-specific manner. The role of the heterodimeric transcription factor hypoxia-inducible factor (HIF) in the pathogenesis of VHL-defective tumors has been more firmly established during the past five years

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