Study details regulation of vital tumor suppressor gene p53

lewis submitted, created time 1 year 4 months (www.eurekalert.org)

So vital is the p53 tumor suppressor gene in controlling cancer that its dysfunction is linked to more than half of human cancers. Now, a just-published study reveals new levels of subtlety in the body's management of this all-important tumor suppressor gene and the protein it produces.

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Susceptibility to type 1 diabetes conferred by the PTPN22 C1858T polymorphism in the Spanish population

diefish submitted, created time 1 year 4 months (www.biomedcentral.com)

“Researchers' results provide evidence that the PTPN22 1858T allele is a T1D susceptibility factor also in the Spanish population and it might play a different role in susceptibility to T1D according to gender in early-onset T1D patients.”

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Up-regulation of Tumor Susceptibility Gene 101 Protein in Ovarian Carcinomas Revealed by Proteomics Analyses

DanyC submitted, created time 1 year 6 months (www.mcponline.org)

"Small GTPase RAS plays a critical role in cellular signaling and oncogenic transformation. Proteomics analysis of genetically defined human ovarian cancer models identified the tumor susceptibility gene 101 (TSG101) as a downstream target of RAS oncogene. Mechanistic studies revealed a novel post-translational regulation of TSG101 through the RAS/RAF/MEK/MAPK signaling pathway and downstream molecules p14ARF/HDM2. Immunoanalysis using ovarian cancer samples and microtissue array revealed elevated TSG101 levels in human ovarian carcinomas

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