Study details regulation of vital tumor suppressor gene p53

lewis submitted, created time 1 year 4 months (www.eurekalert.org)

So vital is the p53 tumor suppressor gene in controlling cancer that its dysfunction is linked to more than half of human cancers. Now, a just-published study reveals new levels of subtlety in the body's management of this all-important tumor suppressor gene and the protein it produces.

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Chemotherapy Thwarted by Cancer-Killing Gene

badboy submitted, created time 1 year 7 months (www.sciam.com)

"A study of ovarian cancer patients undergoing chemotherapy determined that individuals with a mutant, nonfunctional version of the tumor-suppressing gene p53 had a survival rate more than twice as high as counterparts with a properly functioning gene. This, despite the fact that the gene in question is, under normal circumstances, essential for preventing cancer in the first place. "

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