Articles with the keyword: 
Study yields clues to why some tumors spread
sea-maid submitted, created time 6 days 10 hours (www.sciam.com)
A small fragment of genetic material may mean the difference between an easily treated local tumor and an aggressive cancer that spreads throughout the body, U.S. researchers said on Thursday. 
Starving tumors of blood vessels may not be the way to go
piggy submitted, created time 1 week 1 day (www.sciencedaily.com)
Dense networks of blood vessels thought to spur cancer’s growth could actually hinder rather than promote tumor progression, according to a new study at the University of California, San Diego.
The findings partly explain why drugs designed to treat cancer by strangling its blood supply have been disappointing when used alone and why those treatments are more effective when combined with traditional chemotherapy
Tumorigenesis: Keeping a watchful eye
sea-maid submitted, created time 3 weeks 5 days (www.nature.com)
Disruptions in the delicate balance between keratinocyte proliferation and differentiation can contribute towards the development of squamous cell carcinoma (SCC) of the skin — a common human malignancy. It has been proposed that innate surveillants, molecules that promote terminal keratinocyte differentiation, exist in the skin to prevent carcinogenesis, but the conclusive identification of such proteins has not yet been achieved
jerry submitted, created time 2 months 3 weeks (sciencenow.sciencemag.org)
A new study in lab mice suggests that cells may break off from a tumor even before they become cancerous, seeding the body with cells that evade detection and lie dormant for years before turning into tumors of their own.
Enzyme reinforces tumor-causing role of the nuclear coactivator SRC-3
jane2007 submitted, created time 8 months 3 weeks (www.bcm.edu)
A new study shows, high levels of the enzyme atypical protein kinase C (aPKC) increases the activity of the cancer-associated protein steroid receptor coactivator-3 (SRC-3) in cancer cells that depend on estrogen to promote their growth.
Epigenetic Regulation of EpCAM in Tumor Invasion and Metastasis
MedUnion submitted, created time 9 months 1 week (www.mupnet.com)
Metastatic progression is the cause of most cancer decease. Many cell surface adhesion molecules are known to be present or re-expressed following gene promoter CpG island hypomethylation in the early stage of growing tumors, but absent or reduced by gene promoter CpG hypermethylation in metastasized carcinomas. Recent studies have revealed that an adhesion receptor, epithelial cell adhesion molecule (EpCAM), mediates cell-cell interaction and is involved in tumor invasion and metastasis. EpCAM expression was associated with promoter CpG methylation in lung adenocarcinoma
Tumor Time Bombs Set Off by Stem Cells
sumsung submitted, created time 10 months 6 days (www.sciam.com)
Researchers say they have identified a switch that makes dormant breast cancer cells that have traveled to the lungs swell to lethal proportions—completing the dreaded process of metastasis or cancer spread.
DanyC submitted, created time 10 months 1 week (www.nature.com)
"BCL-2 family proteins, which have either pro- or anti-apoptotic activities, have been studied intensively for the past decade owing to their importance in the regulation of apoptosis, tumorigenesis and cellular responses to anti-cancer therapy. They control the point of no return for clonogenic cell survival and thereby affect tumorigenesis and host–pathogen interactions and regulate animal development. "
480 Genes That Control Human Cell Division Identified
Eric wu submitted, created time 10 months 1 week (www.sciencedaily.com)
A team of U.S., Israeli and German scientists used computational biology techniques to discover 480 genes that play a role in human cell division and to identify more than 100 of those genes that have an abnormal pattern of activation in cancer cells.
Study sheds light on how Down's prevents cancer
Sue Wu submitted, created time 10 months 2 weeks (uk.reuters.com)
WASHINGTON (Reuters) - People with Down's syndrome suffer cancer less than most other people and a study in mice published on Wednesday gives one possible explanation -- they produce higher levels of a certain protein.
DanyC submitted, created time 1 year 3 weeks (www.jcb.org)
" These findings demonstrate that loss of Bub1 below a critical threshold drives spontaneous tumorigenesis and suggest that in addition to ensuring proper chromosome segregation, Bub1 is important for mediating cell death when chromosomes missegregate."
jiangyun submitted, created time 1 year 2 months (carcin.oxfordjournals.org)
DNA mismatch repair (MMR) is a highly conserved system that repairs DNA adducts acquired during replication, as well as some forms of exogenous/endogenous DNA damage. Our results support the hypothesis that p53 and Msh6 are functionally interrelated and that, with concomitant mutation, these tumor suppressors act together to accelerate tumorigenesis.
jiangyun submitted, created time 1 year 2 months (carcin.oxfordjournals.org)
Our data provide new insight into the mechanism by which n-3 PUFA suppress tumorigenesis through dampening of inflammation and NF-B activity. These results support a protective role of n-3 PUFA supplementation in the prevention of colorectal cancer.
Role Of Autophagy In Tumorigenesis
Luneetty submitted, created time 1 year 5 months (www.medicalnewstoday.com)
Scientists have reported for the first time, that the cellular self-digesting process of autophagy can protect genome integrity - lending new insight into the seemingly contradictory roles of autophagy as both a cell survival and tumor suppressor pathway.
The Morphogenetic Code and Colon Cancer Development
Paramecium submitted, created time 1 year 8 months (www.cancercell.org)
The initiating genetic lesion in sporadically occurring cancers is impossible to identify. The existence of rare inherited cancer syndromes has helped to uncover some of the mutations that can initiate tumorigenesis. Most of these initiating lesions affect genes belonging to morphogenetic signaling pathways. We review the evidence that the cellular fate of individual epithelial cells in the adult is nonautonomous and depends on extrinsic information, just like cells in a developing embryo
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antibody : Rabbit Anti Pyk2 (Ab-402) (polyclonal)
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