Heart repair may soon be within reach

bigben submitted, created time 1 year 8 months (www.jem.org)

Researchers at the Mayo Clinic, Rochester, MN (Behfar et al., J Exp Med. 2007 Feb 19) found a simple way to isolate a large quantity of cardiac progenitors or cardiopoietic cells, to prevent tumor growth when stem cells are delivered in vivo, to escape from host immunity and ,finally, to repair injured heart. “Recruited cardiopoietic cells delivered in infarcted hearts generated cardiomyocytes that proliferated into scar tissue, integrating with host myocardium for tumor-free repair

2 comments | Blog It | Email It | Keywords: stem embryonic stem (ES) cells embryonic stem cells stem cells Pluripotent stem cells tumorigenic CNS stem cells Stem Cells dividing embryonic stem (ES) cells embryonic stem cells human embryonic stem cells tumorigenic CNS stem cells stem cells Stem Cells dividing Pluripotent stem cells

Baby sperm can be made from bone marrow

angelfish submitted, created time 1 year 8 months (www.abc.net.au)

Stem cells taken from men's bone marrow can be coaxed into something that resembles an immature sperm cell, and their next goal is to see if we can get the spermatogonial stem cells to progress to mature sperm in the laboratory and this should take around three to five years of experiments.

1 comment | Blog It | Email It | Keywords: bone marrow (BM)； tumorigenic CNS stem cells stem cells

Phase I Study of Intraventricular Administration of Rituximab in Patients With Recurrent CNS and Intraocular Lymphoma

fiona submitted, created time 1 year 8 months (jco.ascopubs.org)

"We previously determined that intravenous administration of rituximab results in limited penetration of this agent into the leptomeningeal space. Systemic rituximab does not reduce the risk of CNS relapse or dissemination in patients with large cell lymphoma. We therefore conducted a phase I dose-escalation study of intrathecal rituximab monotherapy in patients with recurrent CNS non-Hodgkin's lymphoma (NHL). "

Submit comment | Blog It | Email It | Keywords: lymphoma large cell lymphoma tumorigenic CNS stem cells

Cells like KG-1 cells'distinct characteristics.

captainclaw submitted, created time 1 year 10 months (genomebiology.com)

“Despite general similarities between mDCs and the model systems, moDCs and KG-1 cells, findings identified some significant differences in the proteomes of these cells, and the findings were confirmed by ELISA detection of a selection of proteins. This was particularly noticeable with proteins involved in cell growth and maintenance (for example, fibrinogen gamma chain and ubiquinol cytochrome c) and cell-cell interaction and integrity (for example, fascin and actin)

Submit comment | Blog It | Email It | Keywords: tumorigenic CNS stem cells maternal cells CD4+ T cells immune cells Corneal epithelial cells

Genetic wonders

angelfish submitted, created time 1 year 10 months (www.newscientist.com)

What saved a man’s life was genetic engineering of the immune system. Cells were taken you’re your body, given a gene that programmed them to attack melanoma cells and then re-implanted. The modified cells survived and thrived, and slowly destroyed his tumours. This survival proves the approach can sometimes work wonders - and soon….

4 comments | Blog It | Email It | Keywords: tumorigenic CNS stem cells genetic work nascent B cells

Olig2-Regulated Lineage-Restricted Pathway Controls Replication Competence in Neural Stem Cells and Malignant Glioma