Articles with the keyword: 
jerry submitted, created time 1 week 1 day (sciencenow.sciencemag.org)
A new study in lab mice suggests that cells may break off from a tumor even before they become cancerous, seeding the body with cells that evade detection and lie dormant for years before turning into tumors of their own. 
Patient, Heal Thyself: Body's Own Immune Cells Whack Late-Stage Tumor
sea-maid submitted, created time 2 weeks 1 day (www.sciam.com)
In what could be a breakthrough in cancer therapy, researchers report in The New England Journal of Medicine today that they succeeded in bolstering a patient's immune system enough to wipe out late-stage malignant tumors on its own. The scientists say the successful experiment could pave the way for new treatments of advanced cancer that spare patients the side effects of chemotherapy, which kills healthy as well as malignant cells.....
New Life for a Discredited Treatment?
sea-maid submitted, created time 4 weeks 7 hours (sciencenow.sciencemag.org)
The long-dormant debate over vitamin C's usefulness for cancer therapy may be about to reignite. Researchers have found that injecting mice with high doses of the vitamin staved off tumor growth. The findings could upend the established view that vitamin C is useless as a cancer treatment.
sea-maid submitted, created time 1 month 10 hours (www.manchester.ac.uk)
University of Manchester researchers are investigating exactly how chemotherapy drugs kill cancerous tumors in a bid to reduce side effects and test the effectiveness of safer new agents.
Virus helps show how cancer spreads
sea-maid submitted, created time 1 month 3 weeks (news.bbc.co.uk)
Scientists have used a common cold virus to "light up" prostate cancer tumors in different parts of the body. A University of California team has found that, when infected by a certain virus, mouse prostate cancer cells become remarkably easy to spot on scanners.
The research team says that the technique requires further development, but if these results extrapolate to humans, it could be a huge boon to cancer research, particularly in cases in which metastasis is suspected.
Natural substance Argyrin shows promise for new cancer therapies
sea-maid submitted, created time 1 month 3 weeks (www.news-medical.net)
The effective treatment of many forms of cancer continues to pose a major problem for medicine. Many tumours fail to respond to standard forms of chemotherapy or become resistant to the medication.
Now scientists have discovered the chemical mechanism by which a natural substance--argyrin--destroys tumours.
sea-maid submitted, created time 1 month 4 weeks (sciencenow.sciencemag.org)
The drugs cancer patients take to destroy their tumors also cause debilitating side effects such as nausea, weight loss, and even heart problems. But now researchers report that they can curb the spread of cancer cells in mice with drug concentrations far lower than the standard dose. The key is using a microscopic particle that zeroes in on blood vessels around the tumor to deliver low doses of the drug in a more concentrated way.
New Weapon for Attacking Tumor Invasion and Metastasis
kavin submitted, created time 2 months 2 weeks (www.mphtimes.com)
A team led by Dr. Ji-Kun Li has determined that AMD3100, originally developed in acquired immune deficiency syndrome treatment, could markedly inhibit spreading of colorectal cancer cells by blocking a new pair of ligands and its unique receptor. This effect differs from the usual inhibition by a conventional chemotherapic agent that is more specific to cancer cells with high metastatic potential.
In vitro, AMD3100 has shown a significantly inhibitory effect on invasion and migration in colorectal cancer cell line. This effect can be further enhanced at higher concentration
Tumor Cell Metabolism: Cancer's Achilles' Heel
jerry submitted, created time 2 months 3 weeks (www.sciencedirect.com)
In this paper, scientists review the peculiarities of tumor cell metabolism that might be taken advantage of for cancer treatment. Specifically, they discuss the alterations in signal transduction pathways and/or enzymatic machineries that account for metabolic reprogramming of transformed cells.
Ted Kennedy Diagnosed with Malignant Brain Tumor
jerry submitted, created time 3 months 2 weeks (www.sciam.com)
The hospital where veteran Democratic Sen. Edward Kennedy has been recuperating following a seizure revealed today that the Massachusetts lawmaker has a malignant brain tumor.
Dynamics of RASSF1A/MOAP-1 Association with Death Receptors
kavin submitted, created time 3 months 2 weeks (www.ncbi.nlm.nih.gov)
RASSF1A associated with the TNF-R1/MOAP-1 or TRAIL-R1/MOAP-1 complex via its N-terminal cysteine-rich (C1) domain containing a potential zinc finger binding motif. Importantly, TNF-R1 association domains on both MOAP-1 and RASSF1A were essential for death receptor-dependent apoptosis. The association of RASSF1A and MOAP-1 with death receptors involves an ordered recruitment to receptor complexes to promote cell death and inhibit tumor formation.
Breast Tumor Cells Have This Molecular Characterization
jerry submitted, created time 3 months 3 weeks (ajp.amjpathol.org)
A detailed understanding of the assortment of genes that are expressed in breast tumor vessels is needed to facilitate the development of novel, molecularly targeted anti-angiogenic agents for breast cancer therapies.
This research found Of the 1176 genes that were differentially expressed between tumor and normal vascular cells, 55 had a greater than fourfold increase in expression level
Direct Genetic Analysis of Single Cancer Cells for Therapy Selection in Cancer
jerry submitted, created time 3 months 3 weeks (www.cancercell.org)
The increasing use of primary tumors as surrogate markers for prognosis and therapeutic decisions neglects evolutionary aspects of cancer progression.
The reseachers identified chromosome 17q12–21, the region comprising HER2, as the most frequent gain in disseminated tumor cells that were isolated from both ectopic sites when they analyzed single disseminated cancer cells from lymph nodes and bone marrow of 107 consecutive esophageal cancer patients.
Tumor cells share oncogenic receptors
sea-maid submitted, created time 3 months 4 weeks (www.jcb.org)
Mutant receptors made in one tumor cell can be passed to tumor cells lacking them.
In this study, the authors found that glioma cells expressing EGFRvIII transferred this errant receptor to nonexpressing cells via microvesicles--small plasma membrane buds. The microvesicles were produced in abundance by the mutant expressing cells and were widely taken up by receptor-negative cells
A Sweet New Role for EGFR ...in Cancer!
jerry submitted, created time 3 months 4 weeks (www.cancercell.org)
The epidermal growth factor (EGFR) has served as an attractive bull's-eye for targeted cancer therapies.
Although the importance of EGFR as an oncogenic tyrosine kinase seems well established, this issue of Cancer Cell adds a new wrinkle to the role of EGFR in cancer. They find that this new function does not require EGFR kinase activity.
In this study, the authors demonstrate that EGFR facilitates glucose transport into cells by associating with and stabilizing a sodium/glucose cotransporter (SGLT1)
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