HNF4A and Diabetes: Injury Before Insult?

jerry submitted, created time 5 months 1 week (diabetes.diabetesjournals.org)

This research tried to confirm a relationship between embryonic environment, particularly intrauterine growth retardation, and later occurrence of type 2 diabetes.

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Diabetes study has surprising results

Sue Wu submitted, created time 9 months 1 week (www.signonsandiego.com)

The doctors' challenge: explain to 21 million Americans with diabetes how they might be affected by a major study's surprise discovery that lower blood sugar levels are linked to greater numbers of deaths.

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Genetic Polymorphism Tied to Sudden Death in Diabetics

kavin submitted, created time 11 months 6 days (www.medscape.com)

NEW YORK (Reuters Health) Dec 14 - The cholesterol ester transfer protein (CETP) TaqIB polymorphism is associated with the risk of sudden death in type 2 diabetic patients, according to French researchers.

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Potential Drug Targets For Treating Type II Diabetes

june submitted, created time 1 year 2 months (www.medicalnewstoday.com)

With the help of genetically engineered mice whose livers turned into glowing light bulbs, researchers at the Salk Institute for Biological Studies have illuminated the underpinnings of an insidious and growing health concern--type II diabetes.

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Healthy diet may decrease diabetes risk

Reviver submitted, created time 1 year 4 months (www.reutershealth.com)

Results of a new study suggest, adopting a diet rich in whole grains, vegetables and fiber while cutting back on red meat and fats may reduce the risk of developing diabetes,

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Generation of DNA cleavage specificities of type II restriction endonucleases by reassortment of target recognition domains

annatto submitted, created time 1 year 5 months (www.pnas.org)

"Type II restriction endonucleases (REases) cleave double-stranded DNA at specific sites within or close to their recognition sequences. Shortly after their discovery in 1970, REases have become one of the primary tools in molecular biology. However, the list of available specificities of type II REases is relatively short despite the extensive search for them in natural sources and multiple attempts to artificially change their specificity

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A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

daphne submitted, created time 1 year 5 months (www.sciencemag.org)

Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting a genome-wide association strategy, we genotyped 1161 Finnish T2D cases and 1174 Finnish normal glucose-tolerant (NGT) controls with >315,000 single-nucleotide polymorphisms (SNPs) and imputed genotypes for an additional >2 million autosomal SNPs.

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Factors Associated with the Incidence of Type 2 Diabetes Mellitus in HIV-Infected Participants in the Swiss HIV Cohort Study

athena submitted, created time 1 year 5 months (www.journals.uchicago.edu)

" Human immunodeficiency virus (HIV)–infected persons may be at increased risk for developing type 2 diabetes mellitus because of viral coinfection and adverse effects of treatment.
Current treatment with protease inhibitor– and nucleoside reverse-transcriptase inhibitor–containing regimens was associated with the risk of developing type 2 diabetes mellitus. "

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Study: Diabetes Drug Use Spikes in Girls

badboy submitted, created time 1 year 6 months (hosted.ap.org)

"The number of adolescent girls taking drugs for Type 2 diabetes nearly tripled in just five years, while use of chronic medicines for psychotic behavior and insomnia roughly doubled among boys and girls aged 10 to 19, a study shows.

Meanwhile, adolescents' use of drugs for depression and attention deficit hyperactivity disorder, or ADHD, leveled off or dropped in the last two years, after widespread new warnings about safety concerns."

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Researchers identify new genetic risk factors for type 2 diabetes

BIOBOSS submitted, created time 1 year 6 months (www.eurekalert.org)

New research, published in the online edition of the journal Science, provides most comprehensive look yet at genetic variants associated with increased risk for type 2 diabetes.

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Study sees major depression connection to diabetes

medal submitted, created time 1 year 6 months (www.reuters.com)

"Elderly people who are depressed are more likely to become diabetic than those who are not, according to a study that suggests depression may play a role in causing the most common form of diabetes."

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Interleukin-1–Receptor Antagonist in Type 2 Diabetes Mellitus

Luneetty submitted, created time 1 year 7 months (content.nejm.org)

The expression of interleukin-1–receptor antagonist is reduced in pancreatic islets of patients with type 2 diabetes mellitus, and high glucose concentrations induce the production of interleukin-1beta in human pancreatic beta cells, leading to impaired insulin secretion, decreased cell proliferation, and apoptosis. In this article, through the blockade of interleukin-1 with anakinra improved glycemia and beta-cell secretory function and reduced markers of systemic inflammation.

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New type of drug helpful in type 2 diabetes

bioman submitted, created time 1 year 7 months (sciam.com)

Treatment with a drug called anakinra improves blood glucose levels and the secretion of insulin by the beta-cells of the pancreas in patients with type 2 diabetes, new research shows. Anakinra, also known by the brand name Kineret, blocks an inflammatory compound in the body called interleukin 1 and is usually used to treat arthritis. Lab findings, however, indicate that it might be helpful in people with type 2 diabetes by protecting beta-cells from glucose-induced impairment.

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Glimepiride Versus Metformin as Monotherapy in Pediatric Patients With Type 2 Diabetes

alpha submitted, created time 1 year 7 months (care.diabetesjournals.org)

"Glimepiride reduced A1C similarly to metformin with greater weight gain, and there was comparable safety over 24 weeks in the treatment of pediatric subjects with type 2 diabetes. "

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Opposing Effects of Adiponectin Receptors 1 and 2 on Energy Metabolism

alpha submitted, created time 1 year 7 months (diabetes.diabetesjournals.org)

"The adipocyte-derived hormone adiponectin regulates glucose and lipid metabolism and influences the risk for developing obesity, type 2 diabetes, and cardiovascular disease."

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