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10

Merck vaccine protects men from wart virus, too

sea-maid submitted, created time 1 month 3 weeks (www.reuters.com)

A vaccine designed to protect women and girls from cervical cancer caused by a wart virus may protect men, too, maker Merck and Co reported on Thursday

8

Bluetongue spreads despite vaccinations

sea-maid submitted, created time 5 months 1 week (www.newscientist.com)

BLUETONGUE is back. It has survived another winter in northern Europe, and now farmers are vaccinating livestock in a race against the biting midges that carry the virus.

The first cases of the disease, which affects ruminants, began to surface this month, with France so far reporting 260. Most are located along the front line of last year's outbreaks, suggesting that the epidemic is spreading into new territory despite France's compulsory vaccination policy.

In England, voluntary vaccination has been rolled out across the country from the south-east, where bluetongue arrived last year

16

Recombinant Plasmodium falciparum reticulocyte homology protein 4 binds to erythrocytes and blocks invasion

william submitted, created time 1 year 2 months (www.pnas.org)

Plasmodium falciparum invasion of human erythrocytes involves several parasite and erythrocyte receptors that enable parasite invasion by multiple redundant pathways. A key challenge to the development of effective vaccines that block parasite infection of erythrocytes is identifying the players in these pathways and determining their function.

6

Antibodies to CD4-induced sites in HIV gp120 correlate with the control of SHIV challenge in macaques vaccinated with subunit immunogens

stephen submitted, created time 1 year 2 months (www.pnas.org)

Epitopes located in and around the coreceptor binding site of HIV-1 envelope glycoprotein (gp120) exhibit enhanced exposure after attachment to the CD4 receptor and comprise some of the most conserved and functionally important residues on the viral envelope. Therefore, antibody responses to these epitopes [designated as CD4-induced (CD4i)] should be highly cross-reactive and potentially useful for HIV vaccine development.

14

Sanofi-Aventis Vaccine Gets FDA Nod

lihuazhang821003 submitted, created time 1 year 2 months (money.cnn.com)

NEW YORK (Associated Press) - Sanofi-Aventis Group said Friday the Food and Drug Administration approved the use of its bacteria-infection vaccine Menactra in children.

The Menactra vaccine, licensed in the U.S. for the prevention of meningococcal disease, treats a rare, serious bacterial infection that often causes meningitis or sepsis, according to the company.

The vaccine first received FDA licensure in 2005 for immunization of adolescents and adults 11 to 55. The FDA's new decision to license Menactra vaccine for children 2 through 10 was based on data from two clinical studies

12

Envelope variation as a primary determinant of lentiviral vaccine efficacy

herry submitted, created time 1 year 3 months (www.pnas.org)

Lentiviral envelope antigenic variation and associated immune evasion are believed to present major obstacles to effective vaccine development. Although this perception is widely assumed by the scientific community, there is, to date, no rigorous experimental data assessing the effect of increasing levels of lentiviral Env variation on vaccine efficacy.

10

Possible Hepatitis C vaccine

sumsung submitted, created time 1 year 4 months (www.eurekalert.org)

Hepatitis C virus infects up to 500,000 people in the UK alone, many of the infections going undiagnosed. It is the single biggest cause of people requiring a liver transplant in Britain. Now scientists have found monoclonal antibodies which may make a successful vaccine a reality, researchers heard today, Sept. 4, 2007, at the Society for General Microbiology's 161st Meeting at the University of Edinburgh, UK, which runs Sept. 3-6, 2007.

9

The Surface-Exposed Proteins of Ehrlichia chaffeensis

DanyC submitted, created time 1 year 4 months (iai.asm.org)

"The identification of E. chaffeensis surface-exposed proteins provides novel insights into the E. chaffeensis surface and lays the foundation for rational studies on pathogen-host interactions and vaccine development."

11

There is a hope for Bird Flu Vaccine

Reviver submitted, created time 1 year 4 months (www.reutershealth.com)

Experts have long said there is no way to vaccinate people against a new strain of influenza until that strain evolves. That could mean months or even years of disease and death before a vaccination campaign began.

9

Surface-Exposed Proteins of Ehrlichia chaffeensis

sharkboy submitted, created time 1 year 5 months (iai.asm.org)

"OMP-1B was undetectable either by surface biotinylation or by Western blotting of the whole bacterial lysate, suggesting that it is not expressed by E. chaffeensis cultured in THP-1 cells. Additional E. chaffeensis surface proteins detected were OMP85, hypothetical protein ECH_0525 , immunodominant surface protein gp47, and 11 other proteins. The identification of E. chaffeensis surface-exposed proteins provides novel insights into the E. chaffeensis surface and lays the foundation for rational studies on pathogen-host interactions and vaccine development."

6

Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis

bianjie submitted, created time 1 year 5 months (www.pnas.org)

Mycobacterium bovis bacille Calmette-Guérin (BCG) is the most widely used live bacterial vaccine. However, limited information is available correlating route and dose of vaccination and induction of specific T cell responses with protection against tuberculosis.

5

Universal flu vaccine being tested on humans

bianjie submitted, created time 1 year 5 months (www.eurekalert.org)

A universal influenza vaccine that has been pioneered by researchers from VIB and Ghent University is being tested for the first time on humans by the British-American biotech company Acambis. This vaccine is intended to provide protection against all "A" strains of the virus that causes human influenza, including pandemic strains.

5

Vaccine trials inject hope into koala's future

bianjie submitted, created time 1 year 5 months (www.news.qut.edu.au)

The first Australian trials of a vaccine developed by Queensland University of Technology that could save Australia's iconic koala from contracting chlamydia are planned to begin later this year.

5

From clinical cancer research: rethinking therapeutic cancer vaccine trials

bianjie submitted, created time 1 year 6 months (www.eurekalert.org)

Ongoing therapeutic cancer vaccine trials have yet to show evidence of vaccines spurring a patient's immune system to shrink tumors -- yet patients who receive these vaccines in trials tend to live longer and respond better to subsequent treatment. In the July 1 issue of Clinical Cancer Research, a journal of the American Association for Cancer Research, a team of National Cancer Institute researchers asks a fundamental question: are we looking at cancer vaccine trials the wrong way?

5

The Tail End of Guinea Worm — Global Eradication without a Drug or a Vaccine

cappuccion submitted, created time 1 year 6 months (content.nejm.org)

Guinea worm disease, or dracunculiasis — Latin for "affliction with little dragons" — is a plague so ancient that it has been found in Egyptian mummies and has been proposed by some to have been the "fiery serpent" described in the Old Testament as torturing the Israelites in the desert. The global Dracunculiasis Eradication Program spearheaded by former President Jimmy Carter and the Carter Center has now reached its final stages

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