Non-peptide arginine-vasopressin antagonists: the vaptans

kavin submitted, created time 7 months 3 weeks (www.ncbi.nlm.nih.gov)

Arginine-vasopressin is a hormone that plays an important part in circulatory and water homoeostasis. These drugs are all effective in the treatment of euvolaemic and hypervolaemic hyponatraemia. Conivaptan is a V1a/V2 non-selective vasopressin-receptor antagonist that has been approved by the US Food and Drug Administration as an intravenous infusion for the inhospital treatment of euvolemic or hypervolemic hyponatremia.

Submit comment | Blog It | Email It | Keywords: hypervolemic sodium hyponatremia conivaptan homeostasis vaptansl arginine vasopressin