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8

A Viral Link to Glioblastoma

sea-maid submitted, created time 2 days 11 hours (www.sciencemag.org)

Circumstantial evidence hints that the cytomegalovirus, a common herpes virus, may play a role in aggressive brain cancer, but big questions remain.

12

Viruses, start your engines!

piggy submitted, created time 1 week 2 days (www.eurekalert.org)

Peering at structures only atoms across, researchers have identified the clockwork that drives a powerful viral nanomotor.

Because of the motor's strength--to scale, twice that of an automobile--the new findings could inspire engineers designing sophisticated nanomachines. In addition, because a number of virus types may possess a similar motor, including the virus that causes herpes, the results may also assist pharmaceutical companies developing methods to sabotage viral machinery.

Researchers from Purdue University in West Lafayette, Ind

8

Biologists learn structure, mechanism of powerful "molecular motor" in virus

piggy submitted, created time 1 week 6 days (news.uns.purdue.edu)

Researchers have discovered the atomic structure of a powerful "molecular motor" that packages DNA into the head segment of some viruses during their assembly, an essential step in their ability to multiply and infect new host organisms.

The researchers, from Purdue University and The Catholic University of America, also have proposed a mechanism for how the motor works

13

Discovery of Lentivirus in Lemur Could Shed Light on History of AIDS and HIV

piggy submitted, created time 1 month 6 days (www.sciencedaily.com)

The genome of a squirrel-sized, saucer-eyed lemur from Madagascar may help scientists understand how HIV-like viruses coevolved with primates, according to new research from the Stanford University School of Medicine. The discovery, to be published online on Dec. 1 in the Proceedings of the National Academy of Sciences, could provide insight into why non-human primates don't get AIDS and lead to treatments for humans.

Scientists have long believed that lentiviruses — the family of viruses that includes HIV — started infecting primates within the past million years

13

Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication

jerry submitted, created time 2 months 3 weeks (www.cell.com)

Human Immunodeficiency Viruses (HIV-1 and HIV-2) rely upon host-encoded proteins to facilitate their replication. Here, we combined genome-wide siRNA analyses with interrogation of human interactome databases to assemble a host-pathogen biochemical network containing 213 confirmed host cellular factors and eleven HIV-1-encoded proteins. Protein complexes that regulate ubiquitin conjugation, proteolysis, DNA-damage response, and RNA splicing were identified as important modulators of early-stage HIV-1 infection

7

HPV infection rates similar in men and women

sea-maid submitted, created time 2 months 4 weeks (www.reuters.com)

Although men are at high risk of acquiring human papillomavirus (HPV) infections, most last no more than a year, about the same time this sexually transmitted disease persists in women, researchers report in The Journal of Infectious Diseases.

7

A Viral Blast from the Past

sea-maid submitted, created time 3 months 6 days (sciencenow.sciencemag.org)

Fifty-year-old sample sheds light on when HIV jumped from chimps to humans.

7

Tissue sample suggests HIV has been infecting humans for a century

sea-maid submitted, created time 3 months 6 days (www.nature.com)

Tissue samples from the fifties and sixties, taken from patients living in Kinshasa (then Leopoldville) in the Democratic Republic of Congo indicate that HIV, which was first recognized in the 1980's. Researchers were able to pluck chinks of viral DNA from the crudely preserved samples. Comparing the levels of genetic variation allowed them to give an estimate of HIV-1's year of origin: 1908.

This does not show us how HIV crossed from chimpanzees into humans, but it does give us a better idea of where to look for the disease's origins.

9

Virus Gets a Taste of Its Own Medicine

jerry submitted, created time 4 months 4 weeks (sciencenow.sciencemag.org)

Little more than protein capsules chock-full of genetic material, viruses barely rank among the living. Yet like people, at least one virus can catch a virus--the viral equivalent of coming down with the flu. This "flu" virus impairs the host virus's ability to grow and reproduce, a research team studying the largest known viruses reports.

Viruses are tiny biological hijackers that cause diseases that include the common cold, the flu, chickenpox, and AIDS. They infect animals, plants, and microorganisms and use their host's cellular machinery to make copies of themselves

9

Virus helps show how cancer spreads

sea-maid submitted, created time 5 months 3 weeks (news.bbc.co.uk)

Scientists have used a common cold virus to "light up" prostate cancer tumors in different parts of the body. A University of California team has found that, when infected by a certain virus, mouse prostate cancer cells become remarkably easy to spot on scanners.

The research team says that the technique requires further development, but if these results extrapolate to humans, it could be a huge boon to cancer research, particularly in cases in which metastasis is suspected.

9

No place to hide for herpes virus

sea-maid submitted, created time 6 months 5 days (www.newscientist.com)

They say the difference between herpes and love is that herpes lasts forever. But new research hints at a way to chase the cold sore virus from its hiding place and get rid of it for good.

10

Higher temperatures helped new strain of West Nile virus spread

sea-maid submitted, created time 6 months 1 week (esciencenews.com)

Higher temperatures helped a new strain of West Nile virus invade and spread across North America, according to a study published in the June 27 issue of the journal PLoS...

7

New Bird Flu Shot Promising

marry submitted, created time 6 months 3 weeks (www.time.com)

The first experimental bird flu vaccine made from lab-grown cells instead of chicken eggs shows promise in blocking the highly lethal virus...

14

Beijing reports first child virus death

sea-maid submitted, created time 7 months 3 weeks (ap.google.com)

This study reports the first death from the hand, foot and mouth disease virus that has sickened tens of thousands of children across the country and killed at least forty-two people.

8

The Way NFAT Recognizes HIV-1 LTR DNA Elements

jerry submitted, created time 7 months 3 weeks (www.structure.org)

The host factor, nuclear factor of activated T-cells (NFAT), regulates the transcription and replication of HIV-1. This study provides a basis for further investigating the functional mechanisms of NFAT in HIV-1 transcription and replication

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