Identification of White Adipocyte Progenitor Cells in Vivo

sea-maid submitted, created time 2 months 3 weeks (www.cell.com)

The increased white adipose tissue (WAT) mass associated with obesity is the result of both hyperplasia and hypertrophy of adipocytes. However, the mechanisms controlling adipocyte number are unknown in part because the identity of the physiological adipocyte progenitor cells has not been defined in vivo. In this report, we employ a variety of approaches, including a noninvasive assay for following fat mass reconstitution in vivo, to identify a subpopulation of early adipocyte progenitor cells (Lin−:CD29+:CD34+:Sca-1+:CD24+) resident in adult WAT

Submit comment | Blog It | Email It | Keywords: apidocytes hypertrophy hyperplasia obesity adipose white adipose tissue WAT progenitor cells White Adipocyte Progenitor Cells

Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity

davidd submitted, created time 11 months 1 week (genomebiology.com)

Investigations performed in mice and humans have acknowledged obesity as a low-grade inflammatory disease. Several molecular mechanisms have been convincingly involved in activating inflammatory processes and altering cell composition in white adipose tissue (WAT). Here, they analyzed the transcriptomic signature of the WAT in obese human subjects, in stable weight conditions and after weight loss following bariatric surgery.

Submit comment | Blog It | Email It | Keywords: inflammation bariatric surgery weight-loss surgery fat adipose white adipose tissue inflammatory disease obesity