Articles with the keyword: 
HWI scientist first in world to unravel structure of key breast cancer target enzyme
piggy submitted, created time 21 hours 15 minutes (www.eurekalert.org)
The molecular details of Aromatase, the key enzyme required for the body to make estrogen, are no longer a mystery thanks to the structural biology work done by the Ghosh lab at the Hauptman-Woodward Medical Research Institute (HWI) in Buffalo, New York. Dr. Debashis Ghosh's solution of the three-dimensional structure of aromatase is the first time that scientists have been able to visualize the mechanism of synthesizing estrogen 
Vaccine to Prevent Breast Cancer Recurrence May Be on the Horizon
sea-maid submitted, created time 2 days 10 hours (www.paktribune.com)
A breast cancer vaccine to prevent recurrence may begin the first stages of clinical trial testing this spring. The new vaccine would not replace traditional cancer treatments but would rather present another option for breast cancer.
Thanks to a six-year, $2.9 million dollar grant from the U.S. Department of Defense Breast Cancer Research Program, a new vaccine to prevent breast cancer recurrence may be on the horizon
Team finds breast cancer gene linked to metastasis
piggy submitted, created time 3 days 2 hours (www.princeton.edu)
A team of researchers at Princeton University and The Cancer Institute of New Jersey has identified a long-sought gene that is fatefully switched on in thirty to forty percent of all breast cancer patients, spreading the disease, resisting traditional chemotherapies and eventually leading to death.
The gene, called "Metadherin" or MTDH, is located in a small region of human chromosome 8 and appears to be crucial to cancer's spread or metastasis because it helps tumor cells stick tightly to blood vessels in distant organs
Dormant cancer cells rely on cellular self-cannibalization to survive
piggy submitted, created time 6 days 7 hours (www.eurekalert.org)
A single tumor-suppressing gene is a key to understanding, and perhaps killing, dormant ovarian cancer cells that persist after initial treatment only to reawaken years later, researchers at the University of Texas M. D. Anderson Cancer Center report in the December Journal of Clinical Investigation.
The team found that expression of a gene called ARHI acts as a switch for autophagy, or self-cannibalization, in ovarian cancer cells. Often a mechanism for cancer cell death, in this case "self-eating" acts as a survival mechanism for dormant cancer cells
How Certain Vegetables Combat Cancer
piggy submitted, created time 1 week 3 days (www.sciencedaily.com)
Women should go for the broccoli when the relish tray comes around during holiday celebrations this season.
While it has been known for some time that eating cruciferous vegetables, such as broccoli, cauliflower, and cabbage, can help prevent breast cancer, the mechanism by which the active substances in these vegetables inhibit cell proliferation was unknown — until now
Hormones Boost Frequency of Migraines with Visual Disturbances in Women
sea-maid submitted, created time 2 weeks 6 hours (www.hon.ch)
In women, hormones increase the frequency of an inherited form of severe migraine accompanied by visual disturbances called auras, according to a Massachusetts General Hospital study.
New Anti-cancer Components of Extra-virgin Olive Oil Revealed
piggy submitted, created time 3 weeks 20 hours (www.sciencedaily.com)
Good quality extra-virgin olive oil contains health-relevant chemicals, called "phytochemicals, that can trigger cancer cell death. New research sheds more light on the suspected association between olive oil-rich Mediterranean diets and reductions in breast cancer risk.
Javier Menendez from the Catalan Institute of Oncology and Antonio Segura-Carretero from the University of Granada in Spain led a team of researchers who set out to investigate which parts of olive oil were most active against cancer
Low Levels of Two Enzymes in Ovarian Cancer Cells Shorten Survival
sea-maid submitted, created time 3 weeks 1 day (www.washingtonpost.com)
Women with ovarian cancer who had low levels of either of two enzymes associated with their tumors tended to die much sooner than women who had higher levels of one of the two enzymes, new research shows.
New Way Men Can Transmit HIV to Women
piggy submitted, created time 3 weeks 1 day (www.sciencedaily.com)
Researchers at Northwestern University have discovered a critical new way a man can transmit the HIV virus to a woman.
Scientists had long believed that the normal lining of the female vaginal tract was an effective barrier to invasion of the HIV virus during sexual intercourse. They thought the large HIV virus couldn't penetrate the tissue.
But new research from Northwestern University's Feinberg School of Medicine has shown for the first time that the HIV virus does indeed penetrate a woman's normal, healthy genital tissue to a depth were it can gain access to its immune cell targets.
Estrogen Pills Can Benefit Women with Metastatic Breast Cancer
sea-maid submitted, created time 3 weeks 6 days (www.newswise.com)
Estrogen-receptor positive metastatic breast cancer often develops resistance to conventional therapies designed to severely lower a woman's estrogen level. A group of researchers headed by a breast cancer specialist at Washington University School of Medicine in St. Louis has found that in one-third of these cases, such tumors will respond, paradoxically, to therapy that raises a woman's estrogen level.
Does Hormone Treatment Predispose Patients to Breast Cancer?
piggy submitted, created time 1 month 1 week (www.sciencedaily.com)
Breast cancer, the leading cause of death among women in France, is the most commonly occurring cancer in women. Sporadic breast cancer, which is non-hereditary, turns out to be the most widespread, representing 85 to 90% of all cases, but remains the least well-known. Researchers at CNRS and CEA (1), working with a team from Hôpital Saint-Louis (2), have just discovered the cause of 50% of sporadic breast cancers.
The results should also explain epidemiological studies which suggest that hormone treatment predisposes patients to breast cancer. The work is published in "Cancer Research
Two New Compounds Show Promise for Eliminating Breast Cancer Tumors
piggy submitted, created time 1 month 2 weeks (www.sciencedaily.com)
Two new compounds created by a University of Central Florida professor show early promise for destroying breast cancer tumors. The compounds disrupt bonding of a cancer-related protein.
Associate Professor James Turkson's compounds disrupt the formation and spread of breast cancer tumors in tests on mice. The compounds, S3I-201 and S3I-M2001, break up a cancer-causing protein called STAT3, and researchers have observed no negative side effects so far.
"The compounds are very promising," Turkson said
Merck vaccine protects men from wart virus, too
sea-maid submitted, created time 1 month 3 weeks (www.reuters.com)
A vaccine designed to protect women and girls from cervical cancer caused by a wart virus may protect men, too, maker Merck and Co reported on Thursday
Industry shifts focus to immunology and cancer
sea-maid submitted, created time 1 month 4 weeks (www.nature.com)
Economic factors, including competition from generic drugs, is hitting even the big pharmaceutical companies hard, reports Nature. In 2010, Pfizer's Lipitor enters the public domain. For these reasons, the larger companies are narrowing the focus of their research, hitting fewer diseases. They're also working on fewer primary care drugs and more drugs that would be prescribed by specialists, such as cancer drugs.
"When Wyeth Pharmaceuticals announced last week that it would cut some of its research and development (R&D) programs in women's health, the decision seemed counterintuitive
A better understanding of inherited breast cancer
sea-maid submitted, created time 2 months 1 week (www.sciencenews.org)
One of the molecular players in breast cancer arising from an inherited mutation has a surprising role in squelching tumors.
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