Yeast reveals sexual selection in action

sea-maid submitted, created time 1 month 4 days (www.nature.com)

The yeast microbe provides way to track evolution gene by gene.

Sexual selection is difficult to work with in complex species. Scientists dispute over whether sexually favored traits represent side effects of healthy immune systems or other desirable traits or whether these preferences arise arbitrarily. One of the reasons that this is so difficult to figure out is that the traits involve multiple genes.

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Synthetic yeast to brew up vital malaria drug

jerry submitted, created time 5 months 2 weeks (www.newscientist.com)

A partly artificial organism could be producing enough of a key malaria drug to treat the world within three years...

3 comments | Blog It | Email It | Keywords: genetic engineering epidemiology epidemics artemisinin drugs malaria yeast Synthetic yeast malaria drug

Structure and function of the yeast U-box-containing ubiquitin ligase Ufd2p

franklin submitted, created time 1 year 1 month (www.pnas.org)

Proteins conjugated by Lys-48-linked polyubiquitin chains are preferred substrates of the eukaryotic proteasome. Polyubiquitination requires an activating enzyme (E1), a conjugating enzyme (E2), and a ligase (E3).

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Novel 3′-phosphoadenosine-5′-phosphatases from extremely halotolerant Hortaea werneckii reveal insight into molecular determinants of salt tolerance of black yeasts

halophiles submitted, created time 1 year 3 months (www.sciencedirect.com)

Two novel 3′-phosphoadenosine-5′-phosphatases, HwHAL2A and HwHAL2B, have been cloned from saltern-inhabited extremely halotolerant yeast Hortaea werneckii, which are ubiquitous enzymes required for the removal of the cytotoxic 3′-phosphoadenosine-5′-phosphate produced during sulfur assimilation in eukaryotes. But addittionally it was shown that they considerably increased the tolerance to sodium and lithium ions when expressed in salt-sensitive S. cerevisiae

1 comment | Blog It | Email It | Keywords: Salt tolerance sulphate metabolism exreme environment phospahtase adaptation yeast agriculture

Quantitative characterization of cell synchronization in yeast

sumsung submitted, created time 1 year 3 months (www.pnas.org)

Metabolic oscillations in baker's yeast serve as a model system for synchronization of biochemical oscillations. Despite widespread interest, the complexity of the phenomenon has been an obstacle for a quantitative understanding of the cell synchronization process.

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Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study

DanyC submitted, created time 1 year 6 months (genomebiology.com)

"The considerable evolutionary distance between budding and fission yeast resulted in substantial diversion in the regulation of copper and iron homeostasis. Despite these differences, the conserved regulation of a core set of genes involved in the uptake of these metals provides valuable clues to key features of metal metabolism."

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The Crystal Structure of Yeast Fatty Acid Synthase, a Cellular Machine with Eight Active Sites Working Together

medal submitted, created time 1 year 7 months (www.cell.com)

"In yeast, the whole metabolic pathway for making 16- and 18-carbon fatty acids is carried out by fatty acid synthase, a 2.6 megadalton molecular-weight macromolecular assembly containing six copies of all eight catalytic centers. "

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Control of the yeast telomeric senescence survival pathways of recombination by the Mec1 and Mec3 DNA damage sensors and RPA

athena submitted, created time 1 year 7 months (nar.oxfordjournals.org)

'Here, we find that the DNA damage sensors, Mec1, Mec3 and Rad24 control Type II recombination, while the Rad9 adaptor protein and the Rad53 and Chk1 effector kinases have no effect on survivor type selection. Therefore, the Mec1 and Mec3 checkpoint complexes control telomeric recombination independently of their roles in generating and amplifying the Mec1-Rad53-Chk1 kinase cascade"

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Putting the brakes on MAPK in the cell cycle

technology submitted, created time 1 year 9 months (www.cell.com)

A Mechanism for Cell-Cycle Regulation of MAP Kinase Signaling in a Yeast Differentiation Pathway.

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