Articles with the keyword: 
DNA scissors enhance gene therapy ...now available to all comers
jerry submitted, created time 3 months 3 weeks (sciencenow.sciencemag.org)
Imagine you're trying to find a cure for a disease, such as cystic fibrosis, which results from a single defective gene. Using traditional gene therapy, you'd infect the patient with a virus containing a good copy of the gene, hoping the DNA inserts into the person's genome in a spot that doesn't trigger cancer.
"There's got to be a better way," you tell yourself--and there is. About a decade ago, researchers began developing a new strategy that relies on proteins called zinc finger nucleases that bind to a very specific place on a chromosome 
Zinc-finger proteins turn T-cells HIV-resistant
Darkfrog submitted, created time 4 months 2 weeks (www.nature.com)
ZInc-finger proteins occur naturally in human cells and regulate gene activity. Researchers out of California's Sangamo Biosciences have figured out how to use these proteins to disrupt and disable specific genes. The kicker? When the gene in question is CCR5, human T-cells suddenly become resistant to infection with HIV.
At this point, any practical treatment would involve removing (or growing) the patient's own T-cells, treating them with zinc finger proteins, and then re0injecting the patient. Cumbersome, but possible
Zinc Finger Targeter (ZiFiT): an engineered zinc finger/target site design tool
diggman submitted, created time 1 year 5 months (nar.oxfordjournals.org)
Zinc Finger Targeter (ZiFiT) is a simple and intuitive web-based tool that facilitates the design of zinc finger proteins (ZFPs) that can bind to specific DNA sequences. ZiFiT output facilitates identification of specific zinc finger modules that are publicly available from the Zinc Finger Consortium. ZiFiT is freely available at http://bindr.gdcb.iastate.edu/ZiFiT/.
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