Recurrent axon collaterals underlie facilitating synapses between cerebellar Purkinje cells
richard submitted, created time 11 months 1 week (www.pnas.org)
Morphological studies have provided ample evidence for synaptic connections between cerebellar Purkinje cells (PCs), but the functional properties of these synapses remain elusive. We report on direct recordings of synaptically connected PCs in mice cerebellar slices. 
Obesity-related hormone is higher in children with Down syndrome
george submitted, created time 11 months 1 week (www.eurekalert.org)
Children with Down syndrome are more likely than their unaffected siblings to have higher levels of a hormone associated with obesity, according to pediatric researchers. The hormone, leptin, may contribute to the known higher risk of obesity among children and adults with Down syndrome.
Fuel cells gearing up to power auto industry
zibba submitted, created time 11 months 6 days (www.uh.edu)
The average price for all types of gasoline is holding steady around $2.95 per gallon nationwide, but the pain at the pump might be short-lived as research from the University of Houston may eliminate one of the biggest hurdles to the wide-scale production of fuel cell-powered vehicles.
Single-molecule level analysis of the subunit composition of the T cell receptor on live T cells
scott submitted, created time 11 months 6 days (www.pnas.org)
The T cell receptor (TCR) expressed on most T cells is a protein complex consisting of TCRαβ heterodimers that bind antigen and cluster of differentiation (CD) 3εδ,εγ,and ζζ dimers that initiate signaling.
Beating heart tissue produced in laboratories
sea-maid submitted, created time 5 months 1 week (www.nature.com)
An international team of researchers has used stem cells to create heart tissue, complete with beat. By treating embryonic stem cells with growth factors, they coaxed them into becoming cardiovascular progenitor cells, which then developed into cardiomyocytes, vascular smooth muscle cells, and endothelial cells, which together form blood vessels. When injected into the hearts of mice with induced heart disease, they improve heart function.
What this discovery does not include is fibroblasts, the cells that form the framework of the heart.
Burrowing mammals dig for a living, but how do they do that?
zibba submitted, created time 11 months 1 week (www.eurekalert.org)
Next time you see a mole digging in tree-root-filled soil in search of supper, take a moment to ponder the mammal's humerus bones. When seen in the lab, they are nothing like the long upper arm bones of any other mammal, says Samantha Hopkins, a paleontologist at the University of Oregon.
Genomic analysis of human microRNA transcripts
jimmy submitted, created time 11 months 1 week (www.pnas.org)
MicroRNAs (miRNAs) are important genetic regulators of development, differentiation, growth, and metabolism. The mammalian genome encodes 500 known miRNA genes. Approximately 50% are expressed from non-protein-coding transcripts, whereas the rest are located mostly in the introns of coding genes.
Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans
franklin submitted, created time 11 months 6 days (www.pnas.org)
The low barometric pressure at high altitude causes lower arterial oxygen content among Tibetan highlanders, who maintain normal levels of oxygen use as indicated by basal and maximal oxygen consumption levels that are consistent with sea level predictions.
What is the mechanisms of work stress and coronary heart disease?
kavin submitted, created time 5 months 2 weeks (eurheartj.oxfordjournals.org)
As known, in mordern times, people are suffering more and more work stress, which would hurt our heart, But wether the inevitability exsist between them is not known. Recently, a new study suggested work stress may be an important determinant of CHD among working-age populations, which is mediated through indirect effects on health behaviours and direct effects on neuroendocrine stress pathways.
Embryonic stem cells coaxed into key heart cells
sumsung submitted, created time 5 months 1 week (www.sciam.com)
Scientists say they have coaxed human embryonic stem cells into becoming three of the major cell types in the human heart, and they improved cardiac function when transplanted into mice. The findings, published in the journal Nature on Wednesday, showed that scientists can efficiently make different kinds of human heart cells for use in basic and clinical research. The researchers said that in the short term, they could be used to test how heart cells respond to different drugs
Intravenous gene therapy protects normal tissue of mice during whole-body radiation
scott submitted, created time 11 months 1 week (www.eurekalert.org)
Gene therapy administered intravenously could be used as an agent to protect vital organs and tissues from the effects of ionizing radiation in the event of large-scale exposure from a radiological or nuclear bomb. In the University of Pittsburgh study, mice were used to test the protective effects of manganese superoxide dismutase plasmid liposome gene therapy on the bone marrow during whole-body irradiation.
'Twinkle after-effect' can help retinal patients detect vision loss quickly and cheaply
davis submitted, created time 11 months 1 week (www.eurekalert.org)
Scientists at Schepens Eye Research Institute have discovered a simple and inexpensive way for patients with retinal and other eye disease to keep track of changes in their vision loss. In a study published in this week's PLoS ONE they demonstrate that a compelling visual illusion known as the induced twinkle after-effect can accurately identify the location and breadth of actual blind spots in people with retinal disease.
Bone marrow cells adopt the cardiomyogenic fate in vivo
sumsung submitted, created time 11 months 1 week (www.pnas.org)
The possibility that adult bone marrow cells (BMCs) retain a remarkable degree of developmental plasticity and acquire the cardiomyocyte lineage after infarction has been challenged, and the notion of BMC transdifferentiation has been questioned.
william submitted, created time 11 months 6 days (www.pnas.org)
Plasmodium falciparum invasion of human erythrocytes involves several parasite and erythrocyte receptors that enable parasite invasion by multiple redundant pathways. A key challenge to the development of effective vaccines that block parasite infection of erythrocytes is identifying the players in these pathways and determining their function.
Genetic Information Nondescrimination Act poised to pass
Darkfrog submitted, created time 5 months 1 week (www.nytimes.com)
The U.S. Congress is preparing a bill that would forbid employers and insurance companies from denying or terminating employment or coverage based on the results of genetic tests. Federal law already prohibits group policies, such as those attained through one's employer or other organization, from discriminating using genetic information, but this bill would apply accross the board.
This bill is likely to pass, and I think it will remove one of the main fears associated with genetic testing (finally finding out that one has a 40% chance of lung cancer is still there, though).
DiscoveR8 is a user-driven website dedicated to the dissemination and intelligent discussion of life science news, discoveries, hypotheses, and procedures. Our users are our sources, editors, and peer reviewers.
abuse@discover8.com
angelfish
Sue Wu
DanyC
jane2007
addictamino acid : Fmoc-L-Phe-OH
www.genscript.com
Adipokinetic Hormone (AKH), Heliothis Zea
Adipokinetic hormones (AKHs) are metabolic neuropeptides, me ...
www.genscript.com
Anorexigenic Peptide
Anorexigenic (AXP)(GLP-HIS-GLY) is an appetite depressing pe ...
www.genscript.com
Stripping Solution
GenScript's Stripping Solution provides a robust but gentle ...
www.genscript.com