1573 Articles with the topic: Biochemistry
Scientists Pull Protein's Tail to Curtail Cancer
piggy submitted, created time 6 days 7 hours (www.sciencedaily.com)
When researchers look inside human cancer cells for the whereabouts of an important tumor-suppressor, they often catch the protein playing hooky, lolling around in cellular broth instead of muscling its way out to the cells’ membranes and foiling cancer growth.
This phenomenon of delinquency puzzled scientists for a long time — until a cell biologist in the Johns Hopkins University School of Medicine felt compelled to genetically grab the protein by the tail and then watched as it got back to work at tamping down disease 
Structure of New Botulism Nerve Toxin Subtype Revealed
piggy submitted, created time 6 days 7 hours (www.sciencedaily.com)
Scientists at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory have determined the atomic-level structure of a third subtype of botulinum neurotoxin — a deadly toxin produced by certain bacteria that causes the disease botulism. It is also used in cosmetic and therapeutic applications such as reducing wrinkles and calming a hyperactive bladder
piggy submitted, created time 2 weeks 21 hours (sciencenow.sciencemag.org)
Talk about Dr. Jekyll and Mr. Hyde. Misfolded proteins known as prions cause mad cow disease and other fatal neurodegenerative illnesses. But in their properly folded form, the proteins may be important to survival, helping mice and other animals keep their sniffing skills sharp, new research shows.
Prions get the bad reputation--and the lion's share of research attention--but interest in the normal form of prion proteins is increasing
New technique is quantum leap forward in understanding proteins
piggy submitted, created time 2 weeks 1 day (www.eurekalert.org)
In this ongoing quest, a group of Scripps Research Institute scientists, along with colleagues from the University of California, San Diego, (UCSD) have borrowed from physics to deliver one of those research rarities—an unmitigated success. The group has devised a computational method that, with remarkable accuracy, predicts how bacterial proteins fold and interact
New Anti-cancer Components of Extra-virgin Olive Oil Revealed
piggy submitted, created time 3 weeks 19 hours (www.sciencedaily.com)
Good quality extra-virgin olive oil contains health-relevant chemicals, called "phytochemicals, that can trigger cancer cell death. New research sheds more light on the suspected association between olive oil-rich Mediterranean diets and reductions in breast cancer risk.
Javier Menendez from the Catalan Institute of Oncology and Antonio Segura-Carretero from the University of Granada in Spain led a team of researchers who set out to investigate which parts of olive oil were most active against cancer
Rhesus protein stops blood from becoming acidic
sea-maid submitted, created time 1 month 2 weeks (www.nature.com)
A protein similar to the Rhesus factor antigens that are used to determine the safety of blood transfusions removes acid from the blood and could have a role in regulating pH elsewhere in the body, too
Nanoparticle Research Aids Drug Development
piggy submitted, created time 1 month 4 weeks (www.sciencedaily.com)
Scientists at the University of Liverpool have developed a new technology which can dramatically improve the effectiveness of antibacterial treatments.
Soluble drugs, soluble antibiotics in this case, that can dissolve in water tend to be more effective at lower doses, but these are rare. Insoluble drugs are more common, but they have to be administered at higher doses so that the patient will feel the same effect
Cytokines and their relationship to the symptoms and outcome of cancer
sea-maid submitted, created time 2 months 4 days (www.nature.com)
Tumors contain immune cells and a network of pro- and anti-inflammatory cytokines, which collaborate in the development and progression of cancer. Cytokine profiles might prove to be prognostic. The systemic effects of pro-inflammatory cytokines are associated with fatigue, depression and cognitive impairment, and can affect quality of life before, during and after treatment. In people with advanced cancer, pro-inflammatory cytokines are additionally associated with anorexia and cachexia, pain, toxicity of treatment and resistance to treatment
Researchers discover that growing up too fast may mean dying young in honey bees
sea-maid submitted, created time 3 months 1 week (www.biologynews.net)
Reactive oxygen species (ROS) occur as a by-product of aerobic metabolism and impair cellular function by damaging proteins, nucleotides and lipids. Organisms possess a variety of anti-oxidant mechanisms to mitigate the effects of ROS, and the oxidative stress model of aging and senescence suggests that physiological performance declines with age due to lifetime accrual of ROS-induced damage and progressively limited anti-oxidant capacity
Protein Kinase CK2: new perspectives of an old kinase
yarmoluk submitted, created time 3 months 2 weeks (www.discover8.com)
Protein Kinase CK2: new perspectives of an old kinase
Design of specific small molecules that are able to block (inhibit) function of macromolecular targets responsible for the development of certain disorder is the “classic” and most widely used approach in modern drug therapeutics, e.g., in cancer treatment
Container chemical causes controversy
jerry submitted, created time 3 months 2 weeks (media.www.spectatornews.com)
The debate over the safety of a chemical ubiquitous in the lives of Americans took center stage at a scientific hearing of the U.S. Food and Drug Administration on Tuesday as federal officials, scientists and health advocates gave vastly different assessments of the effects of exposure to bisphenol A...
Rethinking the Wrinkling: Key Genes Cause Aging
jerry submitted, created time 3 months 2 weeks (www.sciam.com)
Scientists may have been thinking about the causes of aging all wrong. Instead of being the result of an accumulation of genetic and cellular damage, new evidence suggests that aging may occur when genetic programs for development go awry.
Hazardous substances existing in many industries
sea-maid submitted, created time 3 months 2 weeks (www.latimes.com)
Many obstacles, including insufficient investment and lack of training, keep scientists from embracing green chemistry and designing safer substitutes for the vast majority of compounds in use today.
Blocking enzyme could help in rare blood cancer
jerry submitted, created time 3 months 2 weeks (www.reuters.com)
An enzyme that fights some kinds of cancers may foster the growth of a rare type of leukemia that affects babies, U.S. researchers said on Wednesday in a finding that may lead to new drugs for the hard-to-treat disease. There is also talk of applications in Alzheimer's and diabetes.
The enzyme is called glycogen synthase kinase, or GSK3, and blocking it might be an effective way to treat this type of leukemia--for which chemotherapy is characteristically ineffective. Existing drugs used for bipolar disease seem to do a shaky but effective job.
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yarmoluk submitted, created time 3 months 3 weeks (www.otavachemicals.com)
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