125 Articles with the topic: Bioinformatics
National parks spark population growth! ...human populations
Darkfrog submitted, created time 1 month 4 weeks (sciencenow.sciencemag.org)
Despite what critics, proponents, common sense and a proportionate number of the planets 8-balls would have told us, national parks in developing countries are GOOD for people but BAD for animals.
It doesn't make sense on the surface. Opponents of national parks in poor areas have argued that people shouldn't be barred access to traditional hunting grounds, but demographic studies show that human population growth near park borders increases faster than in other places--it implies that people are moving there for the jobs and aid that go hand-in-hand with park placement 
Computational Systems Analysis of Dopamine Metabolism
jerry submitted, created time 2 months 3 days (www.plosone.org)
A prominent feature of Parkinson's disease (PD) is the loss of dopamine in the striatum, and many therapeutic interventions for the disease are aimed at restoring dopamine signaling. Dopamine signaling includes the synthesis, storage, release, and recycling of dopamine in the presynaptic terminal and activation of pre- and post-synaptic receptors and various downstream signaling cascades
Did newborn Earth harbor life?
sea-maid submitted, created time 2 months 3 days (space.newscientist.com)
Life on Earth might have emerged about 750 million years earlier than previously thought, new research suggests.
Building the Tree of Life, Genome by Genome
sea-maid submitted, created time 2 months 5 days (www.sciencemag.org)
Phylogenetic studies have gone 'omic. Whereas researchers used to be satisfied comparing one gene, or a few, to sort out the branching of the tree of life, the push now among those building phylogenies is to consider whole genomes--at the very least, dozens of genes and thousands of DNA bases--in establishing kinships among flora and fauna. In this way, evolutionary biology is joining the bandwagon of data-intensive studies pioneered by genomics
Mechanism and function of humor identified by new evolutionary theory
sea-maid submitted, created time 2 months 1 week (esciencenews.com)
A new publication answers centuries' old questions regarding the mechanism and function of humour, identifying the reason humour is common to all human societies, its fundamental role in the evolution of homo sapiens and its continuing importance in the cognitive...
Dual Functions of the KNOTTED1 Homeodomain
jerry submitted, created time 2 months 2 weeks (stke.sciencemag.org)
This research found KNOTTED1 Homeodomain's dual functions. They are sequence-specific DNA binding and regulation of cell-to-cell transport
Spotlight on stem cell tracking
sea-maid submitted, created time 2 months 3 weeks (www.nature.com)
Making and employing stem cells is hard enough, but observing them is a whole other pack of trouble. This interview with cell imaging guru Timm Schroeder highlights how tough it can be to highlight stem cells in action. In particular, Schroeder talks of the applications of continuous observation. As it turns out, one of the biggest problems is keeping the specimen from moving.
Google launches free patient records
sea-maid submitted, created time 3 months 4 days (www.bmj.com)
The search engine giant has launched Google Health, a free service for patients offering a personal electronic medical record, but the move has prompted fears over the security of health information stored in this way.
Yasushi Saka: Stirring a melting pot of math and morphogens
sea-maid submitted, created time 3 months 4 days (www.jcb.org)
Saka uses a combination of mathematical models, yeast, and frogs to investigate the action of morphogens.
Computational Design of Enzymes
jerry submitted, created time 3 months 1 week (www.sciencedirect.com)
The de novo design of enzymes with activities not found in natural biocatalysts is a major challenge for molecular biology. Sophisticated computational methods have recently led to impressive progress in this exciting and rapidly evolving field...
Direct Genetic Analysis of Single Cancer Cells for Therapy Selection in Cancer
jerry submitted, created time 3 months 3 weeks (www.cancercell.org)
The increasing use of primary tumors as surrogate markers for prognosis and therapeutic decisions neglects evolutionary aspects of cancer progression.
The reseachers identified chromosome 17q12–21, the region comprising HER2, as the most frequent gain in disseminated tumor cells that were isolated from both ectopic sites when they analyzed single disseminated cancer cells from lymph nodes and bone marrow of 107 consecutive esophageal cancer patients.
p53 Activation: A Case against Sir
jerry submitted, created time 3 months 4 weeks (www.cancercell.org)
The p53 tumor suppressor is a critical transcription factor for controlling cell growth and apoptosis during times of cellular stress.
In this issue, the researchers screened small-molecule activators of p53 that could potentially reduce tumor growth Tenovin-6 was identified as a potent SIRT1 and SIRT2 inhibitor that indirectly activated p53 at single-digit micromolar concentrations.
The identification of a specific sirtuin inhibitor has broad implications in understanding sirtuin-p53 signaling and the development of novel chemotherapeutics
sumsung submitted, created time 4 months 4 weeks (sciencenow.sciencemag.org)
Scientists have hit upon a way to spy on invasive wetland species without ever having to see them: They simply detect their DNA in the water. The technique works on bullfrogs, which are an invasive species outside of North America, and such DNA scans could eventually be used in rapid surveys of biodiversity.
The new method of distribution integrals evaluations for high throughput virtual screening
yarmoluk submitted, created time 6 months 5 days (www.bioorganica.org.ua)
A new method of estimating the binding affinity of small organic compounds bound to biological targets is developed. The method incorporates the explicit evaluation of entropy loss for both internal and rotation-translation degrees of freedom. A small set of CK2 inhibitors with resolved crystal structures of their complexes with protein kinase CK2 was successfully fitted to experimentally derived binding constants Ki. The method is computationally efficient and accurate enough to be used in the field of high throughput receptor-oriented virtual screening.
Search for Сasein Kinase 2 inhibitors among 4 aminoquinazoline derivatives
yarmoluk submitted, created time 6 months 5 days (www.bioorganica.org.ua)
75 compounds from combinatorial library of 4-aminoquinazoline derivatives have been chosen using receptor-based virtual screening technology for studying their CK2 inhibition activity. It has been shown that 9 substances inhibit CK2 activity by more than 70%. IC50 of these compounds ranged from 7 to 20 μM. The most potent inhibitor, 1.57 (2-(3-methylphenyl)-4-(4-carboxyphenylamino)quinazolin, has IC50 7.7 μM.
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