24 Articles with the topic: Bioinformatics
The gold standard: Biodesign Institute researchers use nanoparticles to make 3-D DNA nanotubes
piggy submitted, created time 6 days 6 hours (www.eurekalert.org)
Arizona State University researchers Hao Yan and Yan Liu imagine and assemble intricate structures on a scale almost unfathomably small. Their medium is the double-helical DNA molecule, a versatile building material offering near limitless construction potential.
In the January 2, 2009 issue of Science, Yan and Liu, researchers at ASU's Biodesign Institute and faculty in the Department of Chemistry and Biochemistry, reveal for the first time the three-dimensional character of DNA nanotubules, rings and spirals, each a few hundred thousandths the diameter of a human hair 
p53 Activation: A Case against Sir
jerry submitted, created time 7 months 4 weeks (www.cancercell.org)
The p53 tumor suppressor is a critical transcription factor for controlling cell growth and apoptosis during times of cellular stress.
In this issue, the researchers screened small-molecule activators of p53 that could potentially reduce tumor growth Tenovin-6 was identified as a potent SIRT1 and SIRT2 inhibitor that indirectly activated p53 at single-digit micromolar concentrations.
The identification of a specific sirtuin inhibitor has broad implications in understanding sirtuin-p53 signaling and the development of novel chemotherapeutics
Direct Genetic Analysis of Single Cancer Cells for Therapy Selection in Cancer
jerry submitted, created time 7 months 4 weeks (www.cancercell.org)
The increasing use of primary tumors as surrogate markers for prognosis and therapeutic decisions neglects evolutionary aspects of cancer progression.
The reseachers identified chromosome 17q12–21, the region comprising HER2, as the most frequent gain in disseminated tumor cells that were isolated from both ectopic sites when they analyzed single disseminated cancer cells from lymph nodes and bone marrow of 107 consecutive esophageal cancer patients.
Spotlight on stem cell tracking
sea-maid submitted, created time 6 months 3 weeks (www.nature.com)
Making and employing stem cells is hard enough, but observing them is a whole other pack of trouble. This interview with cell imaging guru Timm Schroeder highlights how tough it can be to highlight stem cells in action. In particular, Schroeder talks of the applications of continuous observation. As it turns out, one of the biggest problems is keeping the specimen from moving.
Yasushi Saka: Stirring a melting pot of math and morphogens
sea-maid submitted, created time 7 months 5 days (www.jcb.org)
Saka uses a combination of mathematical models, yeast, and frogs to investigate the action of morphogens.
Google launches free patient records
sea-maid submitted, created time 7 months 5 days (www.bmj.com)
The search engine giant has launched Google Health, a free service for patients offering a personal electronic medical record, but the move has prompted fears over the security of health information stored in this way.
Mechanism and function of humor identified by new evolutionary theory
sea-maid submitted, created time 6 months 1 week (esciencenews.com)
A new publication answers centuries' old questions regarding the mechanism and function of humour, identifying the reason humour is common to all human societies, its fundamental role in the evolution of homo sapiens and its continuing importance in the cognitive...
Towards the Virtual Screening Technique: Trends and Updates
yarmoluk submitted, created time 2 months 6 days (www.otavachemicals.com)
One of the leading Ukrainian companies, OTAVA Ltd. develops its own virtual screening system.
sumsung submitted, created time 8 months 4 weeks (sciencenow.sciencemag.org)
Scientists have hit upon a way to spy on invasive wetland species without ever having to see them: They simply detect their DNA in the water. The technique works on bullfrogs, which are an invasive species outside of North America, and such DNA scans could eventually be used in rapid surveys of biodiversity.
Building the Tree of Life, Genome by Genome
sea-maid submitted, created time 6 months 6 days (www.sciencemag.org)
Phylogenetic studies have gone 'omic. Whereas researchers used to be satisfied comparing one gene, or a few, to sort out the branching of the tree of life, the push now among those building phylogenies is to consider whole genomes--at the very least, dozens of genes and thousands of DNA bases--in establishing kinships among flora and fauna. In this way, evolutionary biology is joining the bandwagon of data-intensive studies pioneered by genomics
Did newborn Earth harbor life?
sea-maid submitted, created time 6 months 5 days (space.newscientist.com)
Life on Earth might have emerged about 750 million years earlier than previously thought, new research suggests.
Codon evolution is governed by linear formulas.
sorimachi submitted, created time 10 months 3 weeks (www.springerlink.com)
A new discavery that codon evolution is governed by linear formulas based on simple calculations of a lot of genomic data. This study has been dirived from the evidence that a gene assembly coding 3,000-7,000 amino acid residues represents the whole genome (Mycoscience 44(5): 415-417, 2003); genome is constructed homogeneously with putative small units coding similar amino acid compositions.
Search for Сasein Kinase 2 inhibitors among 4 aminoquinazoline derivatives
yarmoluk submitted, created time 10 months 1 week (www.bioorganica.org.ua)
75 compounds from combinatorial library of 4-aminoquinazoline derivatives have been chosen using receptor-based virtual screening technology for studying their CK2 inhibition activity. It has been shown that 9 substances inhibit CK2 activity by more than 70%. IC50 of these compounds ranged from 7 to 20 μM. The most potent inhibitor, 1.57 (2-(3-methylphenyl)-4-(4-carboxyphenylamino)quinazolin, has IC50 7.7 μM.
Computational Systems Analysis of Dopamine Metabolism
jerry submitted, created time 6 months 5 days (www.plosone.org)
A prominent feature of Parkinson's disease (PD) is the loss of dopamine in the striatum, and many therapeutic interventions for the disease are aimed at restoring dopamine signaling. Dopamine signaling includes the synthesis, storage, release, and recycling of dopamine in the presynaptic terminal and activation of pre- and post-synaptic receptors and various downstream signaling cascades
National parks spark population growth! ...human populations
Darkfrog submitted, created time 6 months 21 hours (sciencenow.sciencemag.org)
Despite what critics, proponents, common sense and a proportionate number of the planets 8-balls would have told us, national parks in developing countries are GOOD for people but BAD for animals.
It doesn't make sense on the surface. Opponents of national parks in poor areas have argued that people shouldn't be barred access to traditional hunting grounds, but demographic studies show that human population growth near park borders increases faster than in other places--it implies that people are moving there for the jobs and aid that go hand-in-hand with park placement
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