116 Articles with the topic: Chemical Biology
Protein Kinase CK2: new perspectives of an old kinase
yarmoluk submitted, created time 1 week 5 days (www.discover8.com)
Protein Kinase CK2: new perspectives of an old kinase
Design of specific small molecules that are able to block (inhibit) function of macromolecular targets responsible for the development of certain disorder is the “classic” and most widely used approach in modern drug therapeutics, e.g., in cancer treatment 
Walnut trees emit aspirin-like chemical to deal with stress
sea-maid submitted, created time 2 weeks 2 days (esciencenews.com)
Scientists have known for some time that plants can produce their own stress-killers--aspirin is famously produced in willow and walnut trees--but now they've been able to confirm that these compounds are released into the surrounding atmosphere in significant quantities.
OTAVA Ltd. offers MORE THAN 200 NEW FOCUSED COMPOUND LIBRARIES FOR SCREENING.
yarmoluk submitted, created time 3 weeks 3 days (www.otavachemicals.com)
OTAVA Ltd. offers MORE THAN 200 NEW FOCUSED COMPOUND LIBRARIES FOR SCREENING.
They include target-specific compound libraries, e.g, P38 kinase inhibitors, cathepsin B inhibitors, HCV serine protease inhibitors and many others as well as libraries with general pharmacological activities, e.g, antiallergic, antiviral, analgesic and other activities. The focused libraries were designed especially for research and development of new lead compounds.
Experimental chemotherapy regimen shows promise in treating advanced lung cancer
sea-maid submitted, created time 1 month 3 weeks (www.eurekalert.org)
A combination of chemotherapy agents that have been tested in other tumor types appears to be a promising alternative to standard treatment for advanced nonsmall cell lung cancer, according to a report in the Aug. 15 issue of Clinical Cancer Research, a journal of the American Association for Cancer Research.
Happy thoughts may dampen cravings
sea-maid submitted, created time 2 months 4 weeks (www.newscientist.com)
Want to quit smoking? Next time the urge to light up strikes, think of snow-capped peaks instead of the fleeting pleasure of a white cigarette. That's the conclusion of a new brain study which shows that thinking happy thoughts could help dampen cravings.
Mauricio Delgado, a cognitive neuroscientist at Rutgers University in Newark, New Jersey, and his colleague Elizabeth Phelps of New York University measured the brain activity of 15 volunteers as they played a simple game.
The researchers told their subjects to associate blue cards with a real $4 payoff, and yellow cards with nothing
A natural therapeutic agent for breast cancer
jerry submitted, created time 5 months 20 hours (breast-cancer-research.com)
The flavone eupatorin, found in certain plants and used in folk medicine, selectively inhibits the growth of breast carcinoma cells through CYP1 family mediated metabolism, making it a potential chemopreventative candidate.
Heparin contaminated "on purpose"
sea-maid submitted, created time 5 months 6 days (news.bbc.co.uk)
America's drug watchdogs believe that Chinese-made ingredients for a blood-thinning drug may have been deliberately contaminated, but Chinese officials have acknowledged the presence of the contaminant. But they say it is not to blame for the allergic reactions or deaths, citing a lack of incidents in more than 10 other countries which have received the same contaminated stocks.
Organic materials discovered in outer space
Eric wu submitted, created time 6 months 1 week (sciencenow.sciencemag.org)
Radio astronomers have found the first evidence of an amino acid-like molecule in outer space, floating in a dust cloud 25,000 light-years away. Although the discovery doesn't prove that complex organic structures originated in space, it does present strong evidence that the basic ingredients for living organisms exist elsewhere in the galaxy--and that they could be seeding many young planets with life's building blocks.
Ukrainian company Otava develop novel casein kinase 2 (CK2) inhibitors as anticancer drugs.
yarmoluk submitted, created time 7 months 5 days (www.discover8.com)
Over the past few years our company, OTAVA Ltd., has designed novel, efficient at low micro molar concentrations, and selective CK2 inhibitors. To discover the new inhibitors, our researchers spanned computer-based molecular modeling with chemical synthesis of compounds which were further tested in vitro to investigate their ability to bind to and affect the activity of CK2.
Unlocking the potential of bile acids
nonappa submitted, created time 7 months 2 weeks (www.rsc.org)
The article describes about the exploration of bile acids in different fields of science like organic synthesis, bioactivity, supramolecular chemistry, materials chemistry and nanoscience.
DNA Pollution May Be Spawning Killer Microbes
Sue Wu submitted, created time 7 months 2 weeks (discovermagazine.com)
Rogue genetic snippets spread antibiotic resistance all over the environment. But where do they come from in the first place?
Pesticide Brew Spells Trouble for Salmon
Sue Wu submitted, created time 7 months 2 weeks (sciencenow.sciencemag.org)
Salmon in the U.S. Pacific Northwest, and elsewhere, have been in a world of hurt for decades. One of their main enemies is agricultural chemicals, such as chlorpyrifos. The pesticide interferes with salmon brains and harms their ability to feed, according to studies by zoologist Nathaniel Scholz of the National Oceanic and Atmospheric Administration in Seattle, Washington. Now Scholz's research is showing that mixtures of pesticides are even worse for salmon and can be surprisingly lethal.
Codon evolution is governed by linear formulas.
sorimachi submitted, created time 7 months 3 weeks (www.springerlink.com)
A new discavery that codon evolution is governed by linear formulas based on simple calculations of a lot of genomic data. This study has been dirived from the evidence that a gene assembly coding 3,000-7,000 amino acid residues represents the whole genome (Mycoscience 44(5): 415-417, 2003); genome is constructed homogeneously with putative small units coding similar amino acid compositions.
Death, drug reactions spur concern about Botox safety
Sue Wu submitted, created time 7 months 3 weeks (www.latimes.com)
Concerns about the widely used anti-wrinkle treatment Botox and a similar drug arose Friday as federal regulators said they were reviewing reports of at least one death and other serious reactions among some patients.
Charles submitted, created time 8 months 2 weeks (www.sciam.com)
Bowing to pressure from consumer advocates, Pennsylvania officials have dropped plans to bar farmers from revealing whether or not milk hails from hormone-enhanced cows. The state's agriculture department on Thursday issued new guidelines that allow dairies to label milk so that customers know if it was produced from cows pumped with recombinant bovine growth hormone (rBGH) also known as recombinant bovine somatotropin (rBST)
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