45 Articles with the topic: Critical Care & Emergency Medicine
Violence against nurses finally gets some press
Darkfrog submitted, created time 6 months 22 hours (www.nytimes.com)
NUrses treat all kinds of people, including the ones who think nothing of--or are too out of it to think at all--kicking or otherwise attacking their nurse. Nurses have never been strangers to violence. What's new is that the nurses and their unions have been reporting these incidents and are starting to insist on better security at hospitals.
“Nurses find different kinds of responses from their administrations and different levels of support,” said Dr. S. Gerbich of the University of Minnesota 
jerry submitted, created time 6 months 3 weeks (www.genesdev.org)
Osteosarcoma is the most common primary malignant tumor of bone. Analysis of familial cancer syndromes and sporadic cases has strongly implicated both p53 and pRb in its pathogenesis. This research provided a valuable platform for addressing the molecular genetics of osteosarcoma and for developing novel therapeutic strategies.
Foreign body reaction to biomaterials
jerry submitted, created time 6 months 3 weeks (www.sciencedirect.com)
The major focus of this review is on factors that modulate the interaction of macrophages and foreign body giant cells on synthetic surfaces where the chemical, physical, and morphological characteristics of the synthetic surface are considered to play a role in modulating cellular events.
RhoA/Rho-Kinase Contribute to the Pathogenesis of Diabetic Renal Disease
jerry submitted, created time 6 months 4 weeks (diabetes.diabetesjournals.org)
This article tells us that high glucose activates RhoA/Rho-kinase in MCs, leading to downstream AP-1 activation and fibronectin induction. Inhibition of this pathway in vivo prevents the pathologic changes of diabetic nephropathy, supporting a potential role for inhibitors of RhoA/Rho in the treatment of diabetic renal disease.
HNF4A and Diabetes: Injury Before Insult?
jerry submitted, created time 6 months 4 weeks (diabetes.diabetesjournals.org)
This research tried to confirm a relationship between embryonic environment, particularly intrauterine growth retardation, and later occurrence of type 2 diabetes.
Smad1 as a Biomarker for Diabetic Nephropathy
jerry submitted, created time 6 months 4 weeks (diabetes.diabetesjournals.org)
Traditionally, the approach to biomarker identification has mostly been a one-at-a-time strategy. Many well-known tests have been identified to find Smad1 as a biomarker for diabetic nephropathy.
Doctors unprepared to protect themselves from violent patients
sea-maid submitted, created time 7 months 1 week (careers.bmj.com)
One in three doctors is attacked at work every year, yet few of these will have been trained on how to handle the situation. General practitioners, doctors working in accident and emergency departments, psychiatrists, and doctors in training are the most at risk.
Rosiglitazone-Associated Fractures in Type 2 Diabetes
jerry submitted, created time 7 months 3 weeks (care.diabetesjournals.org)
This is an analysis from a diabetes outcome progression trial.
It said that further investigation into the risk factors and underlying pathophysiology for the increased fracture rate in women taking rosiglitazone is required to relate them to preclinical data and better understand the clinical implications of and possible interventions for these findings
Penicillin and meningococcal disease: case-control study
jerry submitted, created time 7 months 3 weeks (student.bmj.com)
This study was performed to ascertain whether penicillin prescribed by a general practitioner before admission to hospital improved children’s outcomes.
Children who were given parenteral penicillin by a general practitioner had more severe disease on reaching hospital than those who were not given penicillin before admission. The association with poor outcome may be because children who are more severely ill are being given penicillin before admission.
HIV Brought the Use of Antidepressants and Risk of Cancer in Individuals Infected with It
jerry submitted, created time 7 months 3 weeks (jco.ascopubs.org)
Antidepressants, irrespective of their class, do not affect cancer risk in HIV-infected individuals.
From a cohort of 10,997 patients representing 52,656 years of follow-up attending a large HIV center during the pre-HAART and HAART eras, a total of 2,004 (18%) were prescribed antidepressants representing 15,850 years exposed. A total of 1,607 (15%) individuals were diagnosed with cancer. There were no significant associations between any class of antidepressant and any type of cancer (P = .19).
Direct Genetic Analysis of Single Cancer Cells for Therapy Selection in Cancer
jerry submitted, created time 7 months 4 weeks (www.cancercell.org)
The increasing use of primary tumors as surrogate markers for prognosis and therapeutic decisions neglects evolutionary aspects of cancer progression.
The reseachers identified chromosome 17q12–21, the region comprising HER2, as the most frequent gain in disseminated tumor cells that were isolated from both ectopic sites when they analyzed single disseminated cancer cells from lymph nodes and bone marrow of 107 consecutive esophageal cancer patients.
Clinical decision modeling system
biomedguru submitted, created time 1 year 2 months (www.biomedcentral.com)
This paper describes the world's first software designed specifically to facilitate integrative translational research. Researchers using the software will be able to plan effective integrative clinical trials that examine the utility of specific clinical workflows that integrate biomarkers, imaging, clinical and demographic data.
The software is available online here:
http://bioinformatics.pitt.edu/software/cdms/
Cancer Council Applauds Prime Minister's Call For Solarium Regulation, Australia
guohong submitted, created time 1 year 4 months (www.medicalnewstoday.com)
The Prime Minister John Howard's announcement today that he would ask Health Minister Tony Abbott to look at uniform national laws on solarium use in Australia was welcomed by the Cancer Council Australia
Preventing Occupational Exposures to Antineoplastic Drugs in Health Care Settings
guohong submitted, created time 1 year 4 months (caonline.amcancersoc.org)
The toxicity of antineoplastic drugs has been well known since they were introduced in the 1940s. Because most antineoplastic drugs are nonselective in their mechanism of action, they affect noncancerous as well as cancerous cells, resulting in well-documented side effects. During the 1970s, evidence came to light indicating health care workers may be at risk of harmful effects from antineoplastic drugs as a result of occupational exposure
Surfactant reduces death in critically ill children
Rhett submitted, created time 1 year 5 months (ccforum.com)
A systematic review of six randomized controlled trials found that exogenous pulmonary surfactant therapy decreases mortality, and is associated with reduced duration of ventilation in children with acute respiratory failure.
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