jerry submitted, created time 7 months 4 weeks (www.cancercell.org)

The increasing use of primary tumors as surrogate markers for prognosis and therapeutic decisions neglects evolutionary aspects of cancer progression.
The reseachers identified chromosome 17q12–21, the region comprising HER2, as the most frequent gain in disseminated tumor cells that were isolated from both ectopic sites when they analyzed single disseminated cancer cells from lymph nodes and bone marrow of 107 consecutive esophageal cancer patients.

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jerry submitted, created time 7 months 3 weeks (care.diabetesjournals.org)

This is an analysis from a diabetes outcome progression trial.
It said that further investigation into the risk factors and underlying pathophysiology for the increased fracture rate in women taking rosiglitazone is required to relate them to preclinical data and better understand the clinical implications of and possible interventions for these findings

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jerry submitted, created time 7 months 3 weeks (student.bmj.com)

This study was performed to ascertain whether penicillin prescribed by a general practitioner before admission to hospital improved children’s outcomes.
Children who were given parenteral penicillin by a general practitioner had more severe disease on reaching hospital than those who were not given penicillin before admission. The association with poor outcome may be because children who are more severely ill are being given penicillin before admission.

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jerry submitted, created time 6 months 3 weeks (www.genesdev.org)

Osteosarcoma is the most common primary malignant tumor of bone. Analysis of familial cancer syndromes and sporadic cases has strongly implicated both p53 and pRb in its pathogenesis. This research provided a valuable platform for addressing the molecular genetics of osteosarcoma and for developing novel therapeutic strategies.

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jerry submitted, created time 7 months 3 weeks (jco.ascopubs.org)

Antidepressants, irrespective of their class, do not affect cancer risk in HIV-infected individuals.

From a cohort of 10,997 patients representing 52,656 years of follow-up attending a large HIV center during the pre-HAART and HAART eras, a total of 2,004 (18%) were prescribed antidepressants representing 15,850 years exposed. A total of 1,607 (15%) individuals were diagnosed with cancer. There were no significant associations between any class of antidepressant and any type of cancer (P = .19).

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jerry submitted, created time 6 months 4 weeks (diabetes.diabetesjournals.org)

Traditionally, the approach to biomarker identification has mostly been a one-at-a-time strategy. Many well-known tests have been identified to find Smad1 as a biomarker for diabetic nephropathy.

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jerry submitted, created time 6 months 3 weeks (www.sciencedirect.com)

The major focus of this review is on factors that modulate the interaction of macrophages and foreign body giant cells on synthetic surfaces where the chemical, physical, and morphological characteristics of the synthetic surface are considered to play a role in modulating cellular events.

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