223 Articles with the topic: Developmental Biology
FoxJ1 Helps Cilia Beat a Path to Asymmetry
piggy submitted, created time 4 days 18 hours (www.sciencedaily.com)
New work at the Salk Institute for Biological Studies reveals how a genetic switch, known as FoxJ1, helps developing embryos tell their left from their right. While at first glance the right and left sides of our bodies are identical to each other, this symmetry is only skin-deep. Below the surface, some of our internal organs are shifted sideways—heart and stomach to the left, liver and appendix to the right.
Creating this left-right asymmetry is a key step in early embryonic development, and requires hundreds of tiny hairlike structures called nodal cilia to beat in unison 
Psychiatry has a new theory of genes and behavior: Genetic tug-of-war determines brain development
Darkfrog submitted, created time 1 week 2 days (www.nytimes.com)
In what the New York Times calls a "creative" interpretation of recent findings about the nature of DNA, two scientists, biologist Bernard Crespi of Fraser University and sociologist Christopher Badcock of the London school of economics, have come up with a new idea of how mental disorders develop and how genes fit into the whole thing:
"Their idea is, in broad outline, straightforward. Dr. Crespi and Dr. Badcock propose that an evolutionary tug of war between genes from the father’s sperm and the mother’s egg can, in effect, tip brain development in one of two ways
DNA "Tattoos" Link Adult, Daughter Stem Cells in Planarians
sea-maid submitted, created time 2 months 6 days (www.sciencedaily.com)
The title of this article is poetic, but it could stand to be better organized. The authors refer to a certain method of DNA identification as a "tattoo," but don't immediately say what it is. One has to dig through the repetitive and error-strewn paragraphs before one finds this:
"the researchers devised methods to detect specific differences in gene expression in the BrdU-labeled cells. The researchers identified 259 genes associated with the stem cells and their daughters
Newly discovered molecular switch helps decide cell type in early embryo development
sea-maid submitted, created time 3 months 1 week (www.eurekalert.org)
Researchers have discovered a central molecular switch in fruit fly embryos that opens new avenues for studying the causes of birth defects and cancer in humans. Writing about their study in the Aug. 12 Developmental Cell, scientists at Cincinnati Children's Hospital Medical Center determined the switch to be a main tuning mechanism for instructing cells whether to form sensory nerves or blood cells in different parts of the body.
Lack of time on tummy shown to hinder achievement
sea-maid submitted, created time 3 months 2 weeks (www.eurekalert.org)
The American Physical Therapy Association is urging parents and caregivers to ensure that babies get enough "tummy time" throughout the day while they are awake and supervised, in light of a recent survey of therapists who say they've noticed an increase in motor delays in infants who spend too much time on their backs while awake.
Early Stage Bone Cells Produce Potential Estrogen Substitute,
kavin submitted, created time 4 months 6 days (www.medicalnewstoday.com)
Cells on their way to forming bone also produce an estrogen-like substance that mimics the naturally occurring female sex hormone estradiol, investigators at the Yale School of Medicine reported Monday in the online edition of the Proceedings of the National Academy of Sciences.
Researchers hope such a molecule might provide some of the benefits but, hopefully, not the health risk of traditional hormonal therapies for menopause and bone loss.
Researchers in the laboratories of Thomas L
Nuclear pores regulate neuronal development
jerry submitted, created time 4 months 4 weeks (www.developmentalcell.com)
The new research reveals a role for structural nucleoporins in coordinating cell differentiation events in the developing embryo.
Spotlight on stem cell tracking
sea-maid submitted, created time 5 months 5 days (www.nature.com)
Making and employing stem cells is hard enough, but observing them is a whole other pack of trouble. This interview with cell imaging guru Timm Schroeder highlights how tough it can be to highlight stem cells in action. In particular, Schroeder talks of the applications of continuous observation. As it turns out, one of the biggest problems is keeping the specimen from moving.
HNF4A and Diabetes: Injury Before Insult?
jerry submitted, created time 5 months 1 week (diabetes.diabetesjournals.org)
This research tried to confirm a relationship between embryonic environment, particularly intrauterine growth retardation, and later occurrence of type 2 diabetes.
Obesity and asthma: Possible mechanisms
jerry submitted, created time 5 months 3 weeks (www.jacionline.org)
Obesity and asthma may share a common etiology, such as common genetics, common in utero conditions, or common predisposing dietary factors. Novel therapeutic strategies for treatment of the obese patient with asthma may result from an increased understanding of the mechanisms underlying this relationship
Injured vets may regrow body parts
jerry submitted, created time 5 months 3 weeks (edition.cnn.com)
The news shows salamander-inspired therapy may aid injured vets. A wounded American soldier underwent a history-making procedure that could help him regrow the finger that was lost to a bomb attack in Baghdad last year...
Life After Extinction: Is There a Tiger in the Mouse?
jerry submitted, created time 5 months 4 weeks (www.sciam.com)
Researchers transfer DNA from the long-vanished Tasmanian tiger into a mouse. The finding shows how lost information about species from the past can be retrieved and also provides a glimpse into how long-gone creatures may someday get a second chance at life.
Developmental defects in a zebrafish model for muscular dystrophies
kavin submitted, created time 6 months 2 days (www.ncbi.nlm.nih.gov)
In this paper, the authors have found that downregulating FKRP in zebrafish results in embryos that develop a range of abnormalities reminiscent of the developmental defects observed in human muscular dystrophies associated with mutations in FKRP.
jerry submitted, created time 6 months 1 week (www.developmentalcell.com)
Surprisingly, sensitive-to-resistant transition happened in post-stage-12 embryos when they are irradiated.
The magic key of this is in the irradiation-responsive enhancer regions of the proapoptotic genes. It becomes enriched for trimethylated H3K27/H3K9 and forms a heterochromatin-like structure during the sensitive-to-resistant transition.
The branching program of mouse lung development
kavin submitted, created time 6 months 1 week (www.nature.com)
Mammalian lungs are branched networks containing thousands to millions of airways arrayed in intricate patterns that are crucial for respiration. The paper presents the complete three-dimensional branching pattern and lineage of the mouse bronchial tree, reconstructed from an analysis of hundreds of developmental intermediates. It also proposes that each mode of branching is controlled by a genetically encoded subroutine, a series of local patterning and morphogenesis operations.
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