38 Articles with the topic: Developmental Biology
The branching program of mouse lung development
kavin submitted, created time 6 months 1 week (www.nature.com)
Mammalian lungs are branched networks containing thousands to millions of airways arrayed in intricate patterns that are crucial for respiration. The paper presents the complete three-dimensional branching pattern and lineage of the mouse bronchial tree, reconstructed from an analysis of hundreds of developmental intermediates. It also proposes that each mode of branching is controlled by a genetically encoded subroutine, a series of local patterning and morphogenesis operations. 
FoxJ1 Helps Cilia Beat a Path to Asymmetry
piggy submitted, created time 4 days 23 hours (www.sciencedaily.com)
New work at the Salk Institute for Biological Studies reveals how a genetic switch, known as FoxJ1, helps developing embryos tell their left from their right. While at first glance the right and left sides of our bodies are identical to each other, this symmetry is only skin-deep. Below the surface, some of our internal organs are shifted sideways—heart and stomach to the left, liver and appendix to the right.
Creating this left-right asymmetry is a key step in early embryonic development, and requires hundreds of tiny hairlike structures called nodal cilia to beat in unison
Spotlight on stem cell tracking
sea-maid submitted, created time 5 months 5 days (www.nature.com)
Making and employing stem cells is hard enough, but observing them is a whole other pack of trouble. This interview with cell imaging guru Timm Schroeder highlights how tough it can be to highlight stem cells in action. In particular, Schroeder talks of the applications of continuous observation. As it turns out, one of the biggest problems is keeping the specimen from moving.
Love can be seen in a different light
Sue Wu submitted, created time 6 months 2 weeks (sciencenow.sciencemag.org)
For people, ultraviolet B (UVB) is an invisible, cancer-causing ray to be blocked with sunscreen and dark glasses, but for a species of jumping spider, the light sets a romantic mood.
Developmental defects in a zebrafish model for muscular dystrophies
kavin submitted, created time 6 months 2 days (www.ncbi.nlm.nih.gov)
In this paper, the authors have found that downregulating FKRP in zebrafish results in embryos that develop a range of abnormalities reminiscent of the developmental defects observed in human muscular dystrophies associated with mutations in FKRP.
Sue Wu submitted, created time 9 months 3 days (www.sciam.com)
Researchers are revealing hidden complexities behind the simple act of kissing, which relays powerful messages to your brain, body and partner
Newly discovered molecular switch helps decide cell type in early embryo development
sea-maid submitted, created time 3 months 1 week (www.eurekalert.org)
Researchers have discovered a central molecular switch in fruit fly embryos that opens new avenues for studying the causes of birth defects and cancer in humans. Writing about their study in the Aug. 12 Developmental Cell, scientists at Cincinnati Children's Hospital Medical Center determined the switch to be a main tuning mechanism for instructing cells whether to form sensory nerves or blood cells in different parts of the body.
Histone Crosstalk between H2B Monoubiquitination and H3 Methylation Mediated by COMPASS
kavin submitted, created time 11 months 6 days (www.cell.com)
"COMPASS, the yeast homolog of the mammalian MLL complex, is a histone H3 lysine 4 (H3K4) methylase consisting of Set1 (KMT2) and seven other polypeptides, including Cps35, the only essential subunit. Histone H2B monoubiquitination by Rad6/Bre1 is required for both H3K4 methylation by COMPASS, and H3K79 methylation by Dot1. However, the molecular mechanism for such histone crosstalk is poorly understood. Here, they demonstrate that histone H2B monoubiquitination controls the binding of Cps35 with COMPASS complex
Canine Behavioral Genetics: Pointing Out the Phenotypes and Herding up the Genes
Sue Wu submitted, created time 10 months 6 days (www.ajhg.org)
"An astonishing amount of behavioral variation is captured within the more than 350 breeds of dog recognized worldwide. Inherent in observations of dog behavior is the notion that much of what is observed is breed specific and will persist, even in the absence of training or motivation."
"Three-parent" technique: mitochondrial replacement could prevent muscular dystrophy and epilepsy
Darkfrog submitted, created time 9 months 2 weeks (news.nationalgeographic.com)
It sounds more impressive than it is -- they've replaced the mitochondria, not portions of the somatic DNA.
A team at Newcastle University has constructed ten embryos, presumably viable, that hold DNA from one man and two women. Doctors see this technique as a means by which parents carrying genetic diseases may have their own (mostly) genetic offspring without going all the way to sperm donors, egg donors or surrogates
Further review of "three-parent" embryo technique
Darkfrog submitted, created time 9 months 2 weeks (www.nature.com)
This is another discussion of the mother-father-mitochondiadonor embryo that I mentioned the other day. It is significantly more revealing. It seems that the mitochondrial transfer involved moving nuclear DNA from the diseased embryo to the healthy one instead of into an ovum from another source.
It also discusses their methods. It seems that the exchange was performed in embryos that had failed in other experiments. The ten successes came from many failures. The specific success to failure ratio is not given.
Sue Wu submitted, created time 9 months 1 week (sciencenow.sciencemag.org)
Wild salmon have it tough these days, with dams blocking the routes to their spawning grounds and invasive predators congregating around their streams. But their worst enemy seems to be farmed salmon, which can infect them with diseases and parasites.
How sperm and egg fuse into one could have applications in antiparasitics
jane2007 submitted, created time 7 months 3 weeks (www.nature.com)
How do sperm and egg fuse into one? A protein called HAP2 is involved with the fusion of egg and sperm in a wide range of species. This fusion protein could be targeted to stop parasites from reproducing.
Metabolism indeed varies between populations
Sue Wu submitted, created time 7 months 12 hours (www.nature.com)
Thousands of frozen urine samples have yielded new information about the diversity of human metabolism across the globe — about who eats what, and how their unique internal microorganisms handle the input.
Life After Extinction: Is There a Tiger in the Mouse?
jerry submitted, created time 5 months 4 weeks (www.sciam.com)
Researchers transfer DNA from the long-vanished Tasmanian tiger into a mouse. The finding shows how lost information about species from the past can be retrieved and also provides a glimpse into how long-gone creatures may someday get a second chance at life.
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