159 Articles with the topic: Hematology
Genetic abnormality may increase risk of blood disorders
piggy submitted, created time 1 year 4 days (www.eurekalert.org)
Researchers at Memorial Sloan-Kettering Cancer Center (MSKCC) have shown for the first time that a tendency to develop some blood disorders may be inherited. Their research, published online today in Nature Genetics, identifies a common genetic sequence abnormality that enhances the likelihood of acquiring a mutation in a gene linked to certain blood diseases.
The investigators carried out a genome-wide study to identify inherited DNA sequence changes that frequently occur in patients with myeloproliferative neoplasms, in which bone marrow produces several types of blood cells excessively 
Cellular discovery may lead to targeted treatment for rare form of anemia
piggy submitted, created time 1 year 5 days (www.eurekalert.org)
University of Cincinnati (UC) researchers have identified the specific biological mechanisms believed to lead to a rare and incurable blood disease known as Diamond Blackfan anemia (DBA). Scientists say with further investigation, their discoveries could result in drastic changes to current thinking about treatment for this disease and may lead to promising new drug therapies.
George Thomas, PhD, Stefano Fumagalli, PhD, and collaborators report their findings online ahead of print in the journal Nature Cell Biology on Sunday, March 15, 2009
The prevalence of gluten-sensitive enteropathy in iron-deficient anemia patients
sea-maid submitted, created time 1 year 2 months (www.eurekalert.org)
A research group from Iran investigated the prevalence of gluten-sensitive enteropathy (GSE) in a large group of patients with iron deficiency anemia (IDA) of obscure origin. They found that there is a high prevalence of GSE in patients with IDA of obscure origin. A gluten-free diet can improve anemia in GSE patients who have mild duodenal lesions without villous atrophy.
Extended Drug Therapy for Hepatitis Is Challenged
sea-maid submitted, created time 1 year 3 months (www.theledger.com)
Patients who do not initially respond to standard drug therapy for treatment of hepatitis C are unlikely to respond to long-term maintenance therapy as well, according to a new study.
sea-maid submitted, created time 1 year 7 months (www.nature.com)
Developing a way to reliably produce hematopoietic stem cells is a bloody tough problem. Unlike most tissues, cells of the hematopoietic system emerge from several embryonic sites and then circulate through the body. This mobility has perplexed researchers, who hope that mimicking the in vivo environment will help them culture these stem cells. Now, two British research teams report in Cell Stem Cell their complementary techniques for isolating these cells. These methods could form the lifeblood of creating easier alternatives to bone marrow transplantation.
Bosentan benefits in mild pulmonary arterial hypertension
kavin submitted, created time 1 year 8 months (www.thelancet.com)
The EARLY study, published in the June 21, 2008 issue of the Lancet, was conducted by a group led by Dr Nazzareno Galič (University of Bologna, Italy).
They note that bosentan has been shown to improve exercise capacity, hemodynamics, and delay clinical worsening in two pivotal clinical trials, but in these, like other trials of treatments for pulmonary arterial hypertension, the vast majority of enrolled patients were in an advanced symptomatic state (WHO functional class 3 and 4)
sumsung submitted, created time 1 year 10 months (sciencenow.sciencemag.org)
A team of clinical trial specialists and consumer advocates has concluded that blood substitutes increase death rates by 30% and nearly triple the risk of heart attacks. Not everyone buys the findings, however, and clinical trials in the field continue.
Pyruvate Kinase Deficiency and Malaria
davidd submitted, created time 1 year 10 months (content.nejm.org)
Malaria that is caused by Plasmodium falciparum is a significant global health problem. Genetic characteristics of the host influence the severity of disease and the ultimate outcome of infection, and there is evidence of coevolution of the plasmodium parasite with its host. In humans, pyruvate kinase deficiency is the second most common erythrocyte enzyme disorder. Here, they show that pyruvate kinase deficiency provides protection against infection and replication of P
Mice Sniff Out Oxygen With Their Skin
lily0558 submitted, created time 1 year 10 months (www.cell.com)
In this paper, researchers have found that a mouse's skin can sense oxygen levels in the air and that it helps regulate the number of oxygen-carrying red blood cells in the body. It is potential that human skin may behave the same way, which could open the door for new ways to boost blood cell levels for athletes seeking to gain an edge or patients with anemia. But they don't yet know how the skin senses the gas.It maybe because of mouse skin containing the same oxygen-sensitive potassium channels as the lung. Humans also carry the HIF-1α gene
Equivalent of a death sentence : Pancreatic cancer
DanyC submitted, created time 2 years 2 weeks (www.stuff.co.nz)
Woo...I have shocked by such new, anyone, who have heard such like below:
Most pancreatic cancer patients are dead within the first year.
Common symptoms of the cancer include appetite loss, weight loss, upset stomach and nausea. The most common physical sign can be jaundice.
Anemia drugs up death risk in cancer patients
sumsung submitted, created time 2 years 3 weeks (www.reuters.com)
Treating cancer patients with anemia drugs increases their risk of blood clots and death, U.S. researchers said on Tuesday, confirming concerns about these widely used drugs. Researchers said the drugs, including Amgen Inc's Aranesp and Johnson & Johnson's Procrit, raised the risk of death by 10 percent in patients who took them, a finding that could not be explained by the higher blood clot risk alone.
Higher Risks: blood clots and death found for anemia anti-anemia drugs
DanyC submitted, created time 2 years 3 weeks (online.wsj.com)
The analysis, which is being published in this week's Journal of the American Medical Association, looked at 51 Phase III clinical studies involving Aranesp, Epogen and Procrit in patients with cancer, and comes amid a continuing safety review of the drugs by the U.S. Food and Drug Administration. Phase III studies are advanced clinical studies that are typically conducted to support FDA approval of products.
Sue Wu submitted, created time 2 years 1 month (abcnews.go.com)
A belief in the healing power of magnets has been around since ancient Greece, leading to a $5 billion a year worldwide industry that supplies millions of believers with magnets for everything from arthritis to cancer to depression. Researchers at the University of Virginia have found some evidence that the use of small magnetic fields may in fact affect blood flow.
davidd submitted, created time 2 years 2 months (bloodjournal.hematologylibrary.org)
The Cooperative Study of Sickle Cell Disease reported that dactylitis, severe anemia, and leukocytosis in very young children with sickle cell disease (SCD) increased the risk of later adverse outcomes, including death, stroke, frequent pain, and recurrent acute chest syndrome. They established a prediction model of adverse outcomes in children with sickle cell anemia. The model will helps doctors choose better treatment for newborn with Sickle Cell Disease to reduce fatal rate.
Tracking Leukemia's Starting Point
sumsung submitted, created time 2 years 2 months (sciencenow.sciencemag.org)
Like all cancers, childhood leukemia starts silently, and how it begins is a perennial puzzle. Some leukemias have been tied to cancer "stem cells" that may drive the early stages of illness and possibly induce relapses. Now researchers in the U.K., Italy, and Japan say they've discovered a stem cell for the most common form of childhood leukemia. Helping them were twin girls, one of whom has the disease and one of whom is healthy.
abuse@discover8.com
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