297 Articles with the topic: Methodology of Basic Research
Eyes: A New Window on Mental Disorders
jerry submitted, created time 2 weeks 6 days (www.sciam.com)
Clues about autism, Williams syndrome and the social brain come from tracking eye movements. This method may be useful, researchers say, because it is not necessary for the participant to understand or even know what the researcher is doing. 
New nano device detects immune system cell signaling
sea-maid submitted, created time 1 month 2 days (esciencenews.com)
Scientists have detected previously unnoticed chemical signals that individual cells use to communicate with each other over short distances. Minding the communiques of individual cells might not be so important for studying the heart or bones, but it is absolutely crucial to studying the immune system.
Postdocs go union in California!
Darkfrog submitted, created time 1 month 3 days (sciencecareers.sciencemag.org)
On their second attempt, University of California postdocs have managed to gather the few thousand signatures that they need to become a labor union eligible for collective bargaining. This brings about 10% of U.S. postdocs into the UAW-affiliated union.
Graduate students have attempted to unionize at a few universities throughout the U.S., with mixed results. At NYU, for example, the students successfully affiliated themselves with United Auto Workers, gaining one contract. Once that contract ran out, however, the University refused to re-recognize the union
New mutant collection examines six thousand genes. Next big thing in drug discovery?
jerry submitted, created time 1 month 4 days (stke.sciencemag.org)
A major challenge in drug discovery is to identify the cellular targets responsible for the pharmacological activity of drug candidates. In the yeast Saccharomyces cerevisiae, a heterozygous diploid mutant collection of approximately six thousand strains, in each of which one copy of a single gene is deleted, is commercially available. With this collection, it is possible to evaluate the role of each gene product in the response of cells to a drug
A natural reprogramming system
sea-maid submitted, created time 1 month 1 week (www.nature.com)
In fruit flies--and presumably other pupating insects--specialized cells revert to multipotency as the larva prepares to transform into an adult. We had thought that the differentiated larval cells simply died during this process, and many of them do, but it does seem that some can regain some pluripotency.
The way they figured this out is particularly vivid. By modifying the cells in the larvae's tracheae to glow green, researchers were able to track their destinations and daughter cells.
We already knew that some human cells were able to perform similar feats
Induced stem cell lines may soon be available from Harvard
Darkfrog submitted, created time 1 month 4 weeks (sciencenow.sciencemag.org)
A few weeks ago, we talked about how researchers had been able to take a cell from an ALS patient and develop a working, research-quality pluripotent cell line. Well the next step has been taken.
I've been saying that induced pluripotent stem cells might become the preferred research model (over embryonic stem cells), but only if they became easier to obtain than embryonic stem cells. It looks as though that might happen soon. The Harvard Stem Cell Institute is dedicating an iPS core lab
Cosmo submitted, created time 3 months 5 days (www.kscitech.com)
For over a century, the Abbe Limit was considered to be a physical law. It's clear now that the ultimate resolution of a basic light microscope was never defined by the Abbe Limit and that the true resolution limit of a basic light microscope is far greater than what Abbe claimed. Why won't manufacturers produce microscopes that offer the full resolution capabilities?
Learning Much from a Bug's Life
sea-maid submitted, created time 3 months 6 days (www.sciencemag.org)
This study uses E. coli as a basis from which one can gain a better understanding of almost every facet of biotic life. This study aims to describe a minute creature, which has arguably helped advance humanity far further than any other organism. Not only has E. coli inhabited human guts for as long as we have existed, but it has also benefited almost all areas of the biological sciences, from genetic engineering to evolutionary theory. To really understand life, it seems we must pay close attention to this bug's life.
UGA research may lead to safer, more effective gene therapy
sea-maid submitted, created time 3 months 1 week (esciencenews.com)
The potential of gene therapy has long been hampered by the risks associated with using viruses as vectors to deliver healthy genes, but a new University of Georgia study helps...
How Much Does Animal Testing Tell Us?
jerry submitted, created time 3 months 2 weeks (www.time.com)
New drugs are routinely tested on mice and other animals before humans. But why are some results translatable to humans and some not?
Nerve stem cells coaxed into working nerve cells
Darkfrog submitted, created time 3 months 2 weeks (www.medicalnewstoday.com)
Researchers at the UT Southwestern Medical Center have found a number of small compounds that stimulate nerve stem cells to develop into nerve cells. They synthesized a version that they are calling isoxazole-9, or ISX-9. This compound seems to have applications in nerve damage and brain cancer chemotheryapy.
Small molecules for stem cells
sea-maid submitted, created time 3 months 3 weeks (www.nature.com)
Embryonic stem cells are hard to grow, study and use. I Sheng Ding of the Scripps Research Institute in La Jolla, California, describes identifying small molecules that not only help improve techniques used to manipulate stem cells in culture but also answer questions about the cells' basic function.
sea-maid submitted, created time 4 months 1 week (www.jcb.org)
Axons that cross the midline of the spinal cord on their way toward the nascent brain, have the complicated task of having to move past local attractants at the midline to complete their journey. Different types of Robo three aloow axons to cross over, but now we know how the body keeps them from crossing back.
Organism Sets Record for Extreme Living Conditions
kavin submitted, created time 4 months 2 weeks (www.sciam.com)
It’s hot to research life in extreme environments. There are organisms that thrive in boiling hot thermal vents and in toxic stews. These extremophiles might show how life could arise on other planets. Or they may provide info that helps solve environmental crises. Based on the genetic analysis, it appears to be a type of archaea—a single-celled organism similar to but distinct from bacteria.
Law enforcement standby gets critiqued: Nature advises that lineups go double-blind
Darkfrog submitted, created time 4 months 2 weeks (www.nature.com)
In the early 1990's, then-attorney general Janet Reno invited scientists to reevaluate the traditional lineup. Many of the people exonerated by the Innocence Project--216 by their count--were identified using lineups, even though DNA evidence later proved that the crimes were committed by other people.
The conclusion: Lineups need to go double-blind. In almost all cases, the person who accompanies the witness to the lineup is the case's overseeing officer, who knows the suspect's identity
abuse@discover8.com
angelfish
Sue Wu
DanyC
jane2007
addict
Parathyroid Hormone (PTH)(1-34)(Human) is a highly purified ...
www.genscript.com
Varicella Zoster Virus gE
E. coli derived recombinant. The protein contains the VZV gE ...
www.genscript.com
Rabbit Anti Akt (Ab-473) (polyclonal)
antibody : Rabbit Anti Akt (Ab-473) (polyclonal)
www.genscript.com
Rabbit Anti CDC2 (Phospho-Tyr15) (Polyclonal)
antibody : Rabbit Anti CDC2 (Phospho-Tyr15) (Polyclonal) ...
www.genscript.com