82 Articles with the topic: Methodology of Basic Research
Cell: A key pathway of acute lung injury-Oxidative
kavin submitted, created time 8 months 2 weeks (www.cell.com)
Multiple lung pathogens such as SARS cause high lethality due to acute respiratory distress syndrome. The researchers, through experiments in mice, indentify oxidative stress and innate immunity as key lung injury pathways that control the severity of ALI. 
Drilling Holes Through Deadly Bacteria's Kevlar-like Hide
piggy submitted, created time 1 week 4 days (www.sciencedaily.com)
To protect themselves from human defenses, disease-causing bacteria have evolved a cell wall made from a nearly impenetrable tangle of tightly woven strands. That’s made it difficult for scientists to see what goes on inside these potentially deadly organisms. But that era is now over. Rockefeller University researchers have now figured out how to drill holes through the Kevlar-like hide of gram-positive bacteria without obliterating them, and in doing so, they’ve made it possible to study, from the inside out, most of the known bacteria on the planet.
The work, led by Vincent A
Microcapsules Act As "Roach Motel" to Harmful Bacteria
piggy submitted, created time 1 month 2 weeks (www.sciencedaily.com)
Scientists at the University of Florida and the University of New Mexico have created tiny microscopic spheres that trap and kill harmful bacteria in a manner the scientists liken to “roach motels” snaring and killing cockroaches. The research could lead to new coatings that will disinfect common surfaces, combat bioterrorism or sterilize medical devices, reducing the devices’ responsibility for an estimated 1.4 million infection-related deaths each year
Logic models of pathway biology
kavin submitted, created time 7 months 3 weeks (www.ncbi.nlm.nih.gov)
Living systems seamlessly perform complex information processing and control tasks using combinatorially complex sets of biochemical reactions. Here, they describe the use of logic as a tractable and informative approach to modelling biological pathways that can allow us to improve our understanding of the dependencies in complex biological processes.
Researchers Develop a Technique for Counting Messages Made by Single Genes
piggy submitted, created time 3 weeks 6 days (www.sciencedaily.com)
Researchers from Albert Einstein College of Medicine of Yeshiva University have described a technique for looking more precisely at a fundamental step of a cell's life — a gene, DNA, being read into a message, mRNA. The technique could provide a window into the process by which genes are switched on inappropriately, causing disease.
The new technique provides a detailed look into processes that until now were proven but never visualized
Nanotubes Sniff Out Cancer Agents in Living Cells
piggy submitted, created time 3 weeks 2 days (www.sciencedaily.com)
MIT engineers have developed carbon nanotubes into sensors for cancer drugs and other DNA-damaging agents inside living cells.
The sensors, made of carbon nanotubes wrapped in DNA, can detect chemotherapy drugs such as cisplatin as well as environmental toxins and free radicals that damage DNA.
"We've made a sensor that can be placed in living cells, healthy or malignant, and actually detect several different classes of molecules that damage DNA," said Michael Strano, associate professor of chemical engineering and senior author of a paper on the work appearing in the Dec
Researchers advance knowledge of little nano-machines in our bodies
piggy submitted, created time 2 weeks 6 days (www.eurekalert.org)
A discovery by Canada-U.S. biophysicists will improve the understanding of ion channels, akin to little "nano-machines" or "nano-valves" in our body, which when they malfunction can cause genetic illnesses that attack muscles, the central nervous system and the heart.
As reported in the current issue of the Proceedings of the National Academy of Sciences (PNAS), researchers from the Université de Montréal and the University of Chicago have developed a novel method to detect the movement of single proteins that control the ion exchange between the cells and their environment
New technique is quantum leap forward in understanding proteins
piggy submitted, created time 2 weeks 1 day (www.eurekalert.org)
In this ongoing quest, a group of Scripps Research Institute scientists, along with colleagues from the University of California, San Diego, (UCSD) have borrowed from physics to deliver one of those research rarities—an unmitigated success. The group has devised a computational method that, with remarkable accuracy, predicts how bacterial proteins fold and interact
Fusing Embryonic Stem Cells with Adult Cells Using Highly Efficient New Fusing System
piggy submitted, created time 3 days 20 hours (www.sciencedaily.com)
MIT engineers have developed a new, highly efficient way to pair up cells so they can be fused together into a hybrid cell.
The new technique should make it much easier for scientists to study what happens when two cells are combined. For example, fusing an adult cell and an embryonic stem cell allows researchers to study the genetic reprogramming that occurs in such hybrids
UGA research may lead to safer, more effective gene therapy
sea-maid submitted, created time 6 months 1 week (esciencenews.com)
The potential of gene therapy has long been hampered by the risks associated with using viruses as vectors to deliver healthy genes, but a new University of Georgia study helps...
Industry shifts focus to immunology and cancer
sea-maid submitted, created time 1 month 4 weeks (www.nature.com)
Economic factors, including competition from generic drugs, is hitting even the big pharmaceutical companies hard, reports Nature. In 2010, Pfizer's Lipitor enters the public domain. For these reasons, the larger companies are narrowing the focus of their research, hitting fewer diseases. They're also working on fewer primary care drugs and more drugs that would be prescribed by specialists, such as cancer drugs.
"When Wyeth Pharmaceuticals announced last week that it would cut some of its research and development (R&D) programs in women's health, the decision seemed counterintuitive
Are plastic tools spoiling experimental results?
sea-maid submitted, created time 1 month 4 weeks (www.nature.com)
Thousands of scientists could be unwittingly ruining their own experiments merely by using standard plastic lab equipment, according to a new study. These findings may have strong implications for the methodology of basic research.
Andrew Holt, a researcher at the University of Alberta in Edmonton, Canada, was looking at how drugs affected the human enzyme monoamine oxidase B when he noticed that the drugs seemed to be inhibiting enzyme activity at much lower concentrations than they should
A Brain Circuit for Bungee Jumping?
sea-maid submitted, created time 1 month 1 week (sciencenow.sciencemag.org)
Scientists have known for some time that the white matter in our brains--the strands of nerve fibers that connect nerve cell bodies, or gray matter--serve as the wires through which neural information flows. However, figuring out exactly which parts of the brain connect to each other, and how strong these connections are, has only been possible recently in living humans thanks to a technique called diffusion tensor imaging. A type of magnetic resonance imaging, the method traces the web of white matter by following the diffusion of fluid through the nerve fibers
Data organization and the modern laboratory
Darkfrog submitted, created time 3 weeks 1 day (judson.blogs.nytimes.com)
This is a New York Times blog post with lots of advice about how to organize data for presentation. Specifically, it's a review of the computer programs Zotero (which is basically Pandora but for scientific papers) and Papers.
Frankly, I don't see the big deal. The writer is talking about how organization got much harder after the journals all went digital. This isn't a new problem. When I was in elementary school, my teachers told me, "When I was a kid, the problem was finding the information. Yours is organizing it
If Life Gives You Methane, Make Methane Energy
Sue Wu submitted, created time 11 months 5 days (discovermagazine.com)
More than a trillion tons of methane lie trapped in permafrost and under frozen lakes in the Arctic. As the region thaws, the gas—a huge potential source of alternative energy—is bubbling out, simultaneously attracting venture capitalists and worrying climatologists.
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