259 Articles with the topic: Methodology of Medical Research
Eyes: A New Window on Mental Disorders
jerry submitted, created time 2 weeks 6 days (www.sciam.com)
Clues about autism, Williams syndrome and the social brain come from tracking eye movements. This method may be useful, researchers say, because it is not necessary for the participant to understand or even know what the researcher is doing. 
New mutant collection examines six thousand genes. Next big thing in drug discovery?
jerry submitted, created time 1 month 4 days (stke.sciencemag.org)
A major challenge in drug discovery is to identify the cellular targets responsible for the pharmacological activity of drug candidates. In the yeast Saccharomyces cerevisiae, a heterozygous diploid mutant collection of approximately six thousand strains, in each of which one copy of a single gene is deleted, is commercially available. With this collection, it is possible to evaluate the role of each gene product in the response of cells to a drug
New MRI Scan Detects Early Arthritis
kavin submitted, created time 1 month 5 days (www.webmd.com)
A new MRI test promises to detect osteoarthritis early, when treatments are most helpful.
The technique also detects spinal disc degeneration, report NYU researchers Alexej Jerschow, PhD, and Ravinder R. Regatte, PhD, at the 236th annual meeting of the American Chemical Society, held Aug. 17-21 in Philadelphia.
"Our methods have the potential of providing early warning signs for cartilage disorders like osteoarthritis, thus potentially avoiding surgery and physical therapy later on," Jerschow says in a news release
Gene therapy experiments improve vision in nearly blind
sea-maid submitted, created time 1 month 5 days (www.newsvine.com)
Scientists for the first time have used gene therapy to dramatically improve sight in people with a rare form of blindness, a development experts called a major advance for the experimental technique. Four of the six patients regained some vision.
New Life for a Discredited Treatment?
sea-maid submitted, created time 1 month 3 weeks (sciencenow.sciencemag.org)
The long-dormant debate over vitamin C's usefulness for cancer therapy may be about to reignite. Researchers have found that injecting mice with high doses of the vitamin staved off tumor growth. The findings could upend the established view that vitamin C is useless as a cancer treatment.
Induced stem cell lines may soon be available from Harvard
Darkfrog submitted, created time 1 month 4 weeks (sciencenow.sciencemag.org)
A few weeks ago, we talked about how researchers had been able to take a cell from an ALS patient and develop a working, research-quality pluripotent cell line. Well the next step has been taken.
I've been saying that induced pluripotent stem cells might become the preferred research model (over embryonic stem cells), but only if they became easier to obtain than embryonic stem cells. It looks as though that might happen soon. The Harvard Stem Cell Institute is dedicating an iPS core lab
Government HIV vaccine doesn't make it out the gate
Darkfrog submitted, created time 2 months 2 weeks (www.nytimes.com)
Plans for a large-scale clinical trial of an HIV vaccine developed by the U.S. government were cancelled this week. The researchers fear jumping into human trials too soon, without knowing more about how their vaccine will affect the volunteers. Here is a quote:
"The trial canceled Thursday was supposed to have started enrolling 8,500 volunteers last October to receive the PAVE [Partnership for AIDS Vaccine Evaluation] vaccine, developed by the infectious diseases agency
Virus helps show how cancer spreads
sea-maid submitted, created time 2 months 2 weeks (news.bbc.co.uk)
Scientists have used a common cold virus to "light up" prostate cancer tumors in different parts of the body. A University of California team has found that, when infected by a certain virus, mouse prostate cancer cells become remarkably easy to spot on scanners.
The research team says that the technique requires further development, but if these results extrapolate to humans, it could be a huge boon to cancer research, particularly in cases in which metastasis is suspected.
Benefits of "magic mushroom" therapy are long lasting
sea-maid submitted, created time 3 months 14 hours (www.nature.com)
The benefits for people who have had positive or even mystical experiences induced by the psychedelic drug psilocybin — the psychoactive ingredient in "magic mushrooms" — linger for as much as a year, according to the latest follow-up study of such patients.
The study offers more support to those who argue that, when used responsibly, some drugs more commonly taken for leisure can safely be used to relieve the stress associated with severe chronic diseases such as cancer.
New antibiotic beats superbugs at their own game
kavin submitted, created time 3 months 2 days (esciencenews.com)
The problem with antibiotics is that, eventually, bacteria outsmart them and become resistant. But by targeting the gene that confers such resistance, a new drug may be able to finally outwit them. Rockefeller University scientists tested the new drug, called Ceftobiprole, against some of the deadliest strains of multidrug-resistant Staphylococcus aureus (MRSA) bacteria, which are responsible for the great majority of staphylococcal infections worldwide, both in hospitals and in the community
The advent of capsule endoscopy--a not-so-futuristic approach to obscure gastrointestinal bleeding
kavin submitted, created time 3 months 1 week (www.ncbi.nlm.nih.gov)
Capsule endoscopy is a new, wireless, endoscopic examination of the small intestine. To date, two small clinical trials have been reported utilizing capsule endoscopy in patients with obscure gastrointestinal bleeding, and have shown its superiority to push enteroscopy in diagnosing the cause of blood loss. No outcome studies have been reported. This paper proposes a change in practice guidelines for obscure bleeding
UGA research may lead to safer, more effective gene therapy
sea-maid submitted, created time 3 months 1 week (esciencenews.com)
The potential of gene therapy has long been hampered by the risks associated with using viruses as vectors to deliver healthy genes, but a new University of Georgia study helps...
New Gene for Alzheimer's Discovered
lily1984 submitted, created time 3 months 1 week (www.bloomberg.com)
Scientists have discovered a gene that raises the risk of late-onset Alzheimer's disease by as much as 77 percent and provides scientists with a second genetic target for developing new treatments for the disorder.
One copy of the gene, called calcium homeostasis modulator 1, or CALHM1, increases the likelihood of late-onset Alzheimer's by 44 percent, while two copies boost the risk 77 percent. About a quarter of the population has one copy, said study author Philippe Marambaud from the Albert Einstein College of Medicine in New York. The research was published in the journal Cell
Symptoms Plus Blood Test Boost Ovarian Cancer Detection
lily1984 submitted, created time 3 months 1 week (www.washingtonpost.com)
U.S. researchers boosted the level of early-stage ovarian cancer detection by 20 percent through use of a blood test to detect a tumor marker as well as a woman's report of new-onset symptoms.
Using either test alone only uncovered about 60 percent of early-stage ovarian cancers in a high-risk group of women, while the two techniques together found 80 percent of early-stage tumors, according to finding published Monday in the online version of the journalCancer
Five new proteins for detecting pancreatic cancer early
kavin submitted, created time 3 months 1 week (medicine.plosjournals.org)
NEW YORK (Reuters Health) Jun 18 - Proteins differentially expressed in a mouse model of pancreatic ductal adenocarcinoma are also present in early-stage disease in humans, scientists report in the June issue of PLoS Medicine.
"There is a compelling need to develop blood-based markers that allow early cancer detection, classify tumors to direct therapy, and monitor disease progression, regression, or recurrence," senior author Dr. Samir M. Hanash, at the Fred Hutchinson Cancer Research Center in Seattle, and his colleagues write
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