265 Articles with the topic: Methodology of Medical Research
Tumor Secrets Written in Blood
piggy submitted, created time 3 days 5 hours (sciencenow.sciencemag.org)
Doctors may soon be able to use blood tests rather than invasive biopsies to figure out what type of brain tumors their patients have. The findings, which come thanks to new insights about how tumor cells communicate with their environment, may also bring physicians closer to the goal of more personalized medicine.
Cells are chatty, constantly exchanging proteins or electrical signals with their neighbors. For example, tumor cells can signal nearby blood vessels to grow in their direction, thereby facilitating tumor growth 
New test to identify heart failure in emergency medicine found superior to current standards
piggy submitted, created time 1 week 2 days (www.reuters.com)
A new blood test to identify heart failure patients in most dire need of treatment when they turn up at an emergency room complaining of shortness of breath proved better than current tests, according to results of a study unveiled on Tuesday.
The pivotal trial of the test developed by privately held German company Brahms AG succeeded in its goal of demonstrating superiority over tests considered the current gold standard.
"I think that this is clearly significantly better than what we have now," Dr. W
Are plastic tools spoiling experimental results?
sea-maid submitted, created time 1 week 3 days (www.nature.com)
Thousands of scientists could be unwittingly ruining their own experiments merely by using standard plastic lab equipment, according to a new study. These findings may have strong implications for the methodology of basic research.
Andrew Holt, a researcher at the University of Alberta in Edmonton, Canada, was looking at how drugs affected the human enzyme monoamine oxidase B when he noticed that the drugs seemed to be inhibiting enzyme activity at much lower concentrations than they should
Nanoparticle Research Aids Drug Development
piggy submitted, created time 1 week 4 days (www.sciencedaily.com)
Scientists at the University of Liverpool have developed a new technology which can dramatically improve the effectiveness of antibacterial treatments.
Soluble drugs, soluble antibiotics in this case, that can dissolve in water tend to be more effective at lower doses, but these are rare. Insoluble drugs are more common, but they have to be administered at higher doses so that the patient will feel the same effect
NIH Suspends Grant to Emory University
jerry submitted, created time 1 month 6 days (sciencenow.sciencemag.org)
The National Institutes of Health (NIH) has suspended a $9 million grant for a depression study led by psychiatrist Charles Nemeroff at Emory University in Atlanta. The punishment, imposed in August but only made public today, is apparently the most severe reaction by NIH so far to a Senate investigation of NIH-funded researchers who may have failed to report all of their income from drug companies.
Recipients of NIH grants are required to report income from industry consulting activities
Genetic technology used to comb mother's blood for fetal DNA
sea-maid submitted, created time 1 month 1 week (www.nature.com)
A blood test that uses next-generation sequencing technology that can identify tiny amounts of fetal DNA floating around in the mother's blood could one day replace more invasive methods as a prenatal test for Down's syndrome and other chromosomal disorders, researchers say.
At present, the two means of pre-natal testing for Down's syndrome, amniocentesis and chorionic villi sampling, both carry a slight risk of miscarriage.
Eyes: A New Window on Mental Disorders
jerry submitted, created time 2 months 5 days (www.sciam.com)
Clues about autism, Williams syndrome and the social brain come from tracking eye movements. This method may be useful, researchers say, because it is not necessary for the participant to understand or even know what the researcher is doing.
New mutant collection examines six thousand genes. Next big thing in drug discovery?
jerry submitted, created time 2 months 2 weeks (stke.sciencemag.org)
A major challenge in drug discovery is to identify the cellular targets responsible for the pharmacological activity of drug candidates. In the yeast Saccharomyces cerevisiae, a heterozygous diploid mutant collection of approximately six thousand strains, in each of which one copy of a single gene is deleted, is commercially available. With this collection, it is possible to evaluate the role of each gene product in the response of cells to a drug
New MRI Scan Detects Early Arthritis
kavin submitted, created time 2 months 3 weeks (www.webmd.com)
A new MRI test promises to detect osteoarthritis early, when treatments are most helpful.
The technique also detects spinal disc degeneration, report NYU researchers Alexej Jerschow, PhD, and Ravinder R. Regatte, PhD, at the 236th annual meeting of the American Chemical Society, held Aug. 17-21 in Philadelphia.
"Our methods have the potential of providing early warning signs for cartilage disorders like osteoarthritis, thus potentially avoiding surgery and physical therapy later on," Jerschow says in a news release
Gene therapy experiments improve vision in nearly blind
sea-maid submitted, created time 2 months 3 weeks (www.newsvine.com)
Scientists for the first time have used gene therapy to dramatically improve sight in people with a rare form of blindness, a development experts called a major advance for the experimental technique. Four of the six patients regained some vision.
New Life for a Discredited Treatment?
sea-maid submitted, created time 3 months 1 week (sciencenow.sciencemag.org)
The long-dormant debate over vitamin C's usefulness for cancer therapy may be about to reignite. Researchers have found that injecting mice with high doses of the vitamin staved off tumor growth. The findings could upend the established view that vitamin C is useless as a cancer treatment.
Induced stem cell lines may soon be available from Harvard
Darkfrog submitted, created time 3 months 1 week (sciencenow.sciencemag.org)
A few weeks ago, we talked about how researchers had been able to take a cell from an ALS patient and develop a working, research-quality pluripotent cell line. Well the next step has been taken.
I've been saying that induced pluripotent stem cells might become the preferred research model (over embryonic stem cells), but only if they became easier to obtain than embryonic stem cells. It looks as though that might happen soon. The Harvard Stem Cell Institute is dedicating an iPS core lab
Government HIV vaccine doesn't make it out the gate
Darkfrog submitted, created time 4 months 3 days (www.nytimes.com)
Plans for a large-scale clinical trial of an HIV vaccine developed by the U.S. government were cancelled this week. The researchers fear jumping into human trials too soon, without knowing more about how their vaccine will affect the volunteers. Here is a quote:
"The trial canceled Thursday was supposed to have started enrolling 8,500 volunteers last October to receive the PAVE [Partnership for AIDS Vaccine Evaluation] vaccine, developed by the infectious diseases agency
Virus helps show how cancer spreads
sea-maid submitted, created time 4 months 4 days (news.bbc.co.uk)
Scientists have used a common cold virus to "light up" prostate cancer tumors in different parts of the body. A University of California team has found that, when infected by a certain virus, mouse prostate cancer cells become remarkably easy to spot on scanners.
The research team says that the technique requires further development, but if these results extrapolate to humans, it could be a huge boon to cancer research, particularly in cases in which metastasis is suspected.
Benefits of "magic mushroom" therapy are long lasting
sea-maid submitted, created time 4 months 2 weeks (www.nature.com)
The benefits for people who have had positive or even mystical experiences induced by the psychedelic drug psilocybin — the psychoactive ingredient in "magic mushrooms" — linger for as much as a year, according to the latest follow-up study of such patients.
The study offers more support to those who argue that, when used responsibly, some drugs more commonly taken for leisure can safely be used to relieve the stress associated with severe chronic diseases such as cancer.
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