1036 Articles with the topic: Molecular Biology
Small molecules mimic natural gene regulators
piggy submitted, created time 9 months 2 weeks (www.ns.umich.edu)
In the quest for new approaches to treating and preventing disease, one appealing route involves turning genes on or off at will, directly intervening in ailments such as cancer and diabetes, which result when genes fail to turn on and off as they should.
Scientists at the University of Michigan and the University of California at Berkeley have taken a step forward on that route by developing small molecules that mimic the behavior and function of a much larger and more complicated natural regulator of gene expression 
piggy submitted, created time 9 months 2 weeks (sciencenow.sciencemag.org)
Anyone who has felt the sting as hydrogen peroxide foams and fizzes on a scraped knee knows about the compound's antiseptic properties. But new research suggests that hydrogen peroxide does more than just kill microbes. It may also call for reinforcements, summoning an army of bacteria-fighting cells to cuts and wounds.
Punctured skin sets off a chain reaction of chemical signals that activates blood-clotting and attracts an array of immune cells to guard against intruding microbes
Proteomics: Finding the key ingredients of disease
piggy submitted, created time 10 months 2 hours (www.eurekalert.org)
The winner of the chilli cook-off, usually has a key secret ingredient, which is hard to identify. Similarly, many diseases have crucial proteins, which change the dynamics of cells from benign to deadly. New findings from an international collaboration, involving McGill University, the Research Institute of the McGill University Health Centre (MUHC) and the Human Proteome Organisation (HUPO) just made identifying these changes one step easier. Their findings published in Nature Methods, show how to improve protein analysis to tease out relevant potential disease-causing molecules
IN RETINAL DISEASE, SIGHT MAY DEPEND ON SECOND SITES
piggy submitted, created time 10 months 1 week (www.hopkinsmedicine.org)
If two people have the same genetic disease, why would one person go blind in childhood but the other later in life or not at all? For a group of genetic diseases — so-called ciliary diseases that include Bardet-Biedl syndrome, Meckel-Gruber syndrome, and Joubert syndrome — the answer lies in one gene that is already linked to two of these diseases and also seems to increase the risk of progressive blindness in patients with other ciliary diseases. The findings are published online this week at Nature Genetics.
New Evidence Of How High Glucose Damages Blood Vessels Could Lead To New Treatments
piggy submitted, created time 10 months 1 week (www.sciencedaily.com)
New evidence of how the elevated glucose levels that occur in diabetes damage blood vessels may lead to novel strategies for blocking the destruction, Medical College of Georgia researchers say.
They found a decreased ability of blood vessels to relax resulted from increased activity of a natural mechanism for altering protein form and function, says Dr. Rita C.Tostes, physiologist in the MCG School of Medicine.
The researchers suspect increased modification of proteins by a glucose-derived molecule is a player in vascular problems associated with hypertension, stroke and obesity as well.
Small molecules might block mutant protein production in Huntington's disease
piggy submitted, created time 10 months 2 weeks (www.eurekalert.org)
Molecules that selectively interfere with protein production can stop human cells from making the abnormal molecules that cause Huntington's disease, researchers at UT Southwestern Medical Center have found.
These man-made molecules also were effective against the abnormal protein that causes Machado-Joseph disease, a neurological condition similar to Huntington's.
The work has been done only in cultured cells, and it will take years before the effectiveness of this process can be tested in patients, the researchers cautioned.
Re-awakening old genes to help in the fight against HIV
piggy submitted, created time 10 months 2 weeks (www.eurekalert.org)
A new vaginal cream containing a reawakened protein could someday prevent the transmission of HIV.
Scientists at the University of Central Florida in Orlando have revived a dormant gene found in humans and coaxed it to produce retrocyclin, a protein that resists HIV.
Lead scientist Alexander Cole used aminoglycosides, drugs commonly used to fight bacterial infections, to trigger the production of the sleeping protein expressed by the retrocyclin gene.
Details of bacterial 'injection' system revealed
piggy submitted, created time 10 months 3 weeks (www.eurekalert.org)
New details of the composition and structure of a needlelike protein complex on the surface of certain bacteria may help scientists develop new strategies to thwart infection. The research, conducted in part at the U.S. Department of Energy's Brookhaven National Laboratory, will be published April 26, 2009, in the advance online edition of Nature Structural & Molecular Biology.
The scientists were studying a needlelike protein complex known as a "type III secretion system," or T3SS, on the surface of Shigella bacteria, a cause of dysentery
Gladstone scientists identify key factors in heart cell creation
piggy submitted, created time 10 months 3 weeks (www.eurekalert.org)
Scientists at the Gladstone Institute of Cardiovascular Disease have identified for the first time key genetic factors that drive the process of generating new heart cells. The discovery, reported in the current issue of the journal Nature, provides important new directions on how stem cells may be used to repair damaged hearts.
For decades, scientists were unable to identify a single factor that could turn nonmuscle cells into beating heart cells. Using a clever approach, the research team led by Benoit Bruneau, Ph.D., found that a combination of three genes could do the trick
Secret to Night Vision Found in DNA's Unconventional Architecture
sea-maid submitted, created time 10 months 3 weeks (www.sciencedaily.com)
Researchers have discovered an important element for making night vision possible in nocturnal mammals: the DNA within the photoreceptor rod cells, which is responsible for low light vision, is packaged in a very unconventional way. That special DNA architecture turns the rod cell nuclei themselves into tiny light-collecting lenses, millions of them in every nocturnal eye.
These results are reported in the April 17th issue of Cell.
Mouse model provides a new tool for investigators of human developmental disorder
piggy submitted, created time 10 months 3 weeks (www.eurekalert.org)
Wolf-Hirschhorn Syndrome (WHS) is a human disease caused by spontaneous genetic deletions. Children born with WHS have a characteristic set of facial features, including a wide flat nose bridge, downturned mouth, high forehead, and highly arched eyebrows. Other symptoms associated with this disease include heart defects, seizures, mental retardation, and skeletal abnormalities, and the severity of these symptoms varies between individual WHS patients.
While it was known that WHS is related to a genetic deletion in chromosome 4, the specific gene or genes affected were unknown
FANTOM studies networks in cells
sea-maid submitted, created time 11 months 8 hours (www.nature.com)
An international consortium has released an analysis of unprecedented detail showing the genes and proteins that guide an immature cell to its final identity. The compendium of data could boost efforts to model the molecular networks that determine cell type — a long-standing goal in systems biology, and possibly a crucial step to creating stem-cell therapies.
New findings resolve long dispute about how Alzheimer's disease might kill brain cells
piggy submitted, created time 11 months 4 days (www.eurekalert.org)
For a decade, Alzheimer's disease researchers have been entrenched in debate about one of the mechanisms believed to be responsible for brain cell death and memory loss.
Now researchers at the University of Michigan and the University of California, San Diego have settled the dispute. Resolving this controversy improves understanding of the disease and could one day lead to better treatments
Scripps scientists uncover mimicry at the molecular level that protects genome integrity
piggy submitted, created time 11 months 6 days (www.eurekalert.org)
This study draws new parallels between the Rad60 DNA repair factor and SUMO, a small ubiquitin-like modifier, both of which are essential to maintaining genome stability during replication. The study was published on April 12, 2009 in an advanced online edition of the Nature Structural & Molecular Biology,
"This collaborative study between our laboratory and the Scripps Research Tainer group shows the very first indication of mimicry in the SUMO pathway," said Scripps Research Assistant Professor Michael "Nick" Boddy, Ph.D., senior author of the study
Penn biologists discover how silent mutations influence protein production
piggy submitted, created time 11 months 1 week (www.eurekalert.org)
Biologists at the University of Pennsylvania have revealed a hidden code that determines the expression level of a gene, providing a way to distinguish efficient genes from inefficient ones. The new research, which involved creating hundreds of synthetic green-glowing genes, provides an explanation for how a cell "knows" how to make just the right amount of protein to maintain homeostasis yet not so much as to cause cell toxicity
abuse@discover8.com
kavin
Darkfrog
angelfish
jane2007
Sue Wu
DanyC
GenScript's custom antibody purification service provides Comprehensive options for purification stage, purifying any antibody Quickly and Efficiently.
www.genscript.com
Plasmid DNA Preparation
GenScript plasmid DNA preparation services offer endotoxin FREE and predominantly supercoiling plasmid DNA from 100 ug to 1000 mg start from $50.
www.genscript.com