213 Articles with the topic: Molecular Medicine
Hormones not for all prostate cancer patients
jerry submitted, created time 1 week 5 days (www.usatoday.com)
A new study raises additional questions about the benefits of drugs given to more than half of prostate cancer patients.
Hormone therapy, which blocks the production of the testosterone that feeds prostate tumors, is a mainstay of treatment for men with advanced disease. Studies show it also improves survival in patients with aggressive tumors that are still limited to the prostate. 
Monoclonal antibodies come of age, and passive immunity treatments come around
sea-maid submitted, created time 1 week 5 days (www.nature.com)
Monoclonal antibodies, antibodies that are made from a single cell line and that bind to a specific part of a specific antigen, are much more precise than polyclonal antibodies, but they are more expensive and difficult to make. However, a new system of isolating antibodies from human patients has been used to create a library of immune proteins. So far, things seem to be going well. This could open the door for what researchers are calling "passive immunity
A new way to identify disease associated genes
jerry submitted, created time 1 week 6 days (www.biodatamining.org)
A new algorithm, which mines databases of tissue specificity, gene connectivity and disease association, has identified a new group of genes that interact with disease-causing genes and impact on disease outcomes.
Experimental RNA drug may cause blindness
lavrock submitted, created time 1 month 1 week (www.nature.com)
Caution needed in clinical trials, scientists urge.
DNA scissors enhance gene therapy ...now available to all comers
jerry submitted, created time 2 months 1 week (sciencenow.sciencemag.org)
Imagine you're trying to find a cure for a disease, such as cystic fibrosis, which results from a single defective gene. Using traditional gene therapy, you'd infect the patient with a virus containing a good copy of the gene, hoping the DNA inserts into the person's genome in a spot that doesn't trigger cancer.
"There's got to be a better way," you tell yourself--and there is. About a decade ago, researchers began developing a new strategy that relies on proteins called zinc finger nucleases that bind to a very specific place on a chromosome
Once suspect protein found to promote DNA repair, prevent cancer
sea-maid submitted, created time 2 months 2 weeks (esciencenews.com)
An abundant chromosomal protein that binds to damaged DNA prevents cancer development by enhancing DNA repair, researchers at The University of Texas M. D. Anderson Cancer Center report online this week in the Proceedings of the National Academies of Science. The protein, HMGB1, was previously hypothesized to block DNA repair, senior author Karen Vasquez, Ph.D., associate professor in M. D. Anderson's Department of Carcinogenesis at the Science Park - Research Division in Smithville, Texas.
UGA research may lead to safer, more effective gene therapy
sea-maid submitted, created time 3 months 1 week (esciencenews.com)
The potential of gene therapy has long been hampered by the risks associated with using viruses as vectors to deliver healthy genes, but a new University of Georgia study helps...
jerry submitted, created time 3 months 2 weeks (www.genesdev.org)
Osteosarcoma is the most common primary malignant tumor of bone. Analysis of familial cancer syndromes and sporadic cases has strongly implicated both p53 and pRb in its pathogenesis. This research provided a valuable platform for addressing the molecular genetics of osteosarcoma and for developing novel therapeutic strategies.
Smad1 as a Biomarker for Diabetic Nephropathy
jerry submitted, created time 3 months 3 weeks (diabetes.diabetesjournals.org)
Traditionally, the approach to biomarker identification has mostly been a one-at-a-time strategy. Many well-known tests have been identified to find Smad1 as a biomarker for diabetic nephropathy.
Fireflies' glow gene helps researchers evaluate cancer drugs
Sue Wu submitted, created time 4 months 4 days (www.topnews.in)
Researchers at UT Southwestern Medical Center have used a gene, which produces a flash in fireflies, to track the effectiveness of anti-cancer drugs.
In a first of its kind effort, researchers have now shown that a technique called bioluminescence imaging (BLI) can be used to determine the effectiveness of cancer drugs that obstruct the blood supply to a tumor.
jerry submitted, created time 4 months 2 weeks (jco.ascopubs.org)
This study tells us that both clinical patient characteristics and molecular tumor markers may be used to predict the likelihood of response to EGFR TKI therapy.
It is likely—indeed probably inevitable—that a panel of tests will be used in the not too distant future to determine which patients are likely to respond, and of almost equal importance, to determine which patients are unlikely to derive benefit from EGFR inhibitor therapy
Breast Tumor Cells Have This Molecular Characterization
jerry submitted, created time 4 months 3 weeks (ajp.amjpathol.org)
A detailed understanding of the assortment of genes that are expressed in breast tumor vessels is needed to facilitate the development of novel, molecularly targeted anti-angiogenic agents for breast cancer therapies.
This research found Of the 1176 genes that were differentially expressed between tumor and normal vascular cells, 55 had a greater than fourfold increase in expression level
Rosiglitazone-Associated Fractures in Type 2 Diabetes
jerry submitted, created time 4 months 3 weeks (care.diabetesjournals.org)
This is an analysis from a diabetes outcome progression trial.
It said that further investigation into the risk factors and underlying pathophysiology for the increased fracture rate in women taking rosiglitazone is required to relate them to preclinical data and better understand the clinical implications of and possible interventions for these findings
Cytokines as Therapeutic Targets: Advances and Limitations
jerry submitted, created time 4 months 3 weeks (www.immunity.com)
Biological therapies targeting cytokines, T cells, or B cells have improved outcomes of inflammatory diseases. However, many issues remain open: What is the best target? How well can response be predicted? How can cure be achieved?
This article will answer these questions.
The Way NFAT Recognizes HIV-1 LTR DNA Elements
jerry submitted, created time 4 months 3 weeks (www.structure.org)
The host factor, nuclear factor of activated T-cells (NFAT), regulates the transcription and replication of HIV-1. This study provides a basis for further investigating the functional mechanisms of NFAT in HIV-1 transcription and replication
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