217 Articles with the topic: Molecular Medicine
Biogen, Genentech to codevelop cancer drug
piggy submitted, created time 2 weeks 6 days (finance.yahoo.com)
CAMBRIDGE, Mass. (AP) -- Biogen Idec Inc. said Thursday it will pay Genentech Inc. $31.5 million upfront under a deal to co-develop a potential cancer treatment.
The companies will develop GA101, now in early-to-midstage studies as a possible treatment for non-Hodgkins lymphoma and chronic lymphocytic leukemia. Both conditions are blood cancers. 
A better understanding of inherited breast cancer
sea-maid submitted, created time 3 weeks 7 hours (www.sciencenews.org)
One of the molecular players in breast cancer arising from an inherited mutation has a surprising role in squelching tumors.
New way to control protein activity could lead to cancer therapies
sea-maid submitted, created time 4 weeks 1 day (www.sciencecentric.com)
Investigators at the Stanford University School of Medicine have found a way to quickly and reversibly fine-tune the activity of individual proteins in cells and living mammals, providing a powerful new laboratory tool for identifying-more precisely than ever before-the functions of different proteins.
The new technique also could help to speed the development of therapies in which cancer-fighting proteins are selectively delivered to tumors.
Biological principles of microRNA-mediated regulation: shared themes amid diversity
sea-maid submitted, created time 1 month 1 day (www.nature.com)
Regulation of gene activity by microRNAs is critical to myriad aspects of eukaryotic development and physiology. Amidst an extensive regulatory web that is predicted to involve thousands of transcripts, emergent themes are now beginning to illustrate how microRNAs have been incorporated into diverse settings. These include potent inhibition of individual key targets, fine-tuning of target activity, the coordinated regulation of target batteries, and the reversibility of some aspects of microRNA-mediated repression
Hormones not for all prostate cancer patients
jerry submitted, created time 1 month 4 weeks (www.usatoday.com)
A new study raises additional questions about the benefits of drugs given to more than half of prostate cancer patients.
Hormone therapy, which blocks the production of the testosterone that feeds prostate tumors, is a mainstay of treatment for men with advanced disease. Studies show it also improves survival in patients with aggressive tumors that are still limited to the prostate.
Monoclonal antibodies come of age, and passive immunity treatments come around
sea-maid submitted, created time 1 month 4 weeks (www.nature.com)
Monoclonal antibodies, antibodies that are made from a single cell line and that bind to a specific part of a specific antigen, are much more precise than polyclonal antibodies, but they are more expensive and difficult to make. However, a new system of isolating antibodies from human patients has been used to create a library of immune proteins. So far, things seem to be going well. This could open the door for what researchers are calling "passive immunity
A new way to identify disease associated genes
jerry submitted, created time 1 month 4 weeks (www.biodatamining.org)
A new algorithm, which mines databases of tissue specificity, gene connectivity and disease association, has identified a new group of genes that interact with disease-causing genes and impact on disease outcomes.
Experimental RNA drug may cause blindness
lavrock submitted, created time 2 months 3 weeks (www.nature.com)
Caution needed in clinical trials, scientists urge.
DNA scissors enhance gene therapy ...now available to all comers
jerry submitted, created time 3 months 3 weeks (sciencenow.sciencemag.org)
Imagine you're trying to find a cure for a disease, such as cystic fibrosis, which results from a single defective gene. Using traditional gene therapy, you'd infect the patient with a virus containing a good copy of the gene, hoping the DNA inserts into the person's genome in a spot that doesn't trigger cancer.
"There's got to be a better way," you tell yourself--and there is. About a decade ago, researchers began developing a new strategy that relies on proteins called zinc finger nucleases that bind to a very specific place on a chromosome
Once suspect protein found to promote DNA repair, prevent cancer
sea-maid submitted, created time 3 months 4 weeks (esciencenews.com)
An abundant chromosomal protein that binds to damaged DNA prevents cancer development by enhancing DNA repair, researchers at The University of Texas M. D. Anderson Cancer Center report online this week in the Proceedings of the National Academies of Science. The protein, HMGB1, was previously hypothesized to block DNA repair, senior author Karen Vasquez, Ph.D., associate professor in M. D. Anderson's Department of Carcinogenesis at the Science Park - Research Division in Smithville, Texas.
UGA research may lead to safer, more effective gene therapy
sea-maid submitted, created time 4 months 3 weeks (esciencenews.com)
The potential of gene therapy has long been hampered by the risks associated with using viruses as vectors to deliver healthy genes, but a new University of Georgia study helps...
jerry submitted, created time 5 months 4 days (www.genesdev.org)
Osteosarcoma is the most common primary malignant tumor of bone. Analysis of familial cancer syndromes and sporadic cases has strongly implicated both p53 and pRb in its pathogenesis. This research provided a valuable platform for addressing the molecular genetics of osteosarcoma and for developing novel therapeutic strategies.
Smad1 as a Biomarker for Diabetic Nephropathy
jerry submitted, created time 5 months 1 week (diabetes.diabetesjournals.org)
Traditionally, the approach to biomarker identification has mostly been a one-at-a-time strategy. Many well-known tests have been identified to find Smad1 as a biomarker for diabetic nephropathy.
Fireflies' glow gene helps researchers evaluate cancer drugs
Sue Wu submitted, created time 5 months 2 weeks (www.topnews.in)
Researchers at UT Southwestern Medical Center have used a gene, which produces a flash in fireflies, to track the effectiveness of anti-cancer drugs.
In a first of its kind effort, researchers have now shown that a technique called bioluminescence imaging (BLI) can be used to determine the effectiveness of cancer drugs that obstruct the blood supply to a tumor.
jerry submitted, created time 6 months 4 days (jco.ascopubs.org)
This study tells us that both clinical patient characteristics and molecular tumor markers may be used to predict the likelihood of response to EGFR TKI therapy.
It is likely—indeed probably inevitable—that a panel of tests will be used in the not too distant future to determine which patients are likely to respond, and of almost equal importance, to determine which patients are unlikely to derive benefit from EGFR inhibitor therapy
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