46 Articles with the topic: Molecular Medicine
The findings about How Stomach Tumors Form
sea-maid submitted, created time 8 months 2 weeks (www.wlns.com)
Stomach cancer is the second most common cause of cancer-related deaths worldwide. Many people are rightly concerned about this disease. In this article, the study shows us how stomach tumors form. Stomach cancer has been shown, previously, to be correlated with chronic inflammation. 
the construction of gene therapy for blood disorders
sea-maid submitted, created time 8 months 2 weeks (bloodjournal.hematologylibrary.org)
The concept of introducing genes into human cells for therapeutic purposes developed nearly 50 years ago as diseases due to defects in specific genes were recognized. The development history of gene therapy for blood disorders was introduced in this paper.
Protein test predicts invasive breast cancer
sea-maid submitted, created time 8 months 1 week (www.newscientist.com)
Cancer is one of the world’s biggest killers. Only have we known more about the principal of the breast cancer, we can create more useful methods to prevent the diseaes. Now, a team at the University of California has developed a test that can determine whether or not a woman's tumor will turn invasive--and whether or not she should go through with surgery.
Environmental and genetic modifiers of the progression to fibrosis and cirrhosis in hemochromatosis
sea-maid submitted, created time 8 months 1 week (bloodjournal.hematologylibrary.org)
Hemochromatosis is a disease related to a relatively common and easily identifiable genetic defect, but the extent of clinical expression is variable and to a large extent remains unexplained. But this review explores recent developments in knowledge of environmental and genetic modifiers of this process.
Blocking brain enzyme helped mice stay slim
kavin submitted, created time 8 months 2 days (feeds.feedburner.com)
In this study, the researchers found that blocking a single brain enzyme helped short-circuit a key hunger signal in mice and made them eat less, lose weight and have better blood sugar control. While much more research lies ahead, they said the finding may lead to new treatments for obesity and diabetes in humans.
Clock-gene variants linked to diabetes
sea-maid submitted, created time 1 month 20 hours (www.nature.com)
Fresh evidence suggests that melatonin, a hormone that regulates the body's biological clock, is associated with type 2 diabetes.
Rosiglitazone-Associated Fractures in Type 2 Diabetes
jerry submitted, created time 7 months 3 weeks (care.diabetesjournals.org)
This is an analysis from a diabetes outcome progression trial.
It said that further investigation into the risk factors and underlying pathophysiology for the increased fracture rate in women taking rosiglitazone is required to relate them to preclinical data and better understand the clinical implications of and possible interventions for these findings
Fireflies' glow gene helps researchers evaluate cancer drugs
Sue Wu submitted, created time 7 months 6 days (www.topnews.in)
Researchers at UT Southwestern Medical Center have used a gene, which produces a flash in fireflies, to track the effectiveness of anti-cancer drugs.
In a first of its kind effort, researchers have now shown that a technique called bioluminescence imaging (BLI) can be used to determine the effectiveness of cancer drugs that obstruct the blood supply to a tumor.
UGA research may lead to safer, more effective gene therapy
sea-maid submitted, created time 6 months 1 week (esciencenews.com)
The potential of gene therapy has long been hampered by the risks associated with using viruses as vectors to deliver healthy genes, but a new University of Georgia study helps...
Biological principles of microRNA-mediated regulation: shared themes amid diversity
sea-maid submitted, created time 2 months 2 weeks (www.nature.com)
Regulation of gene activity by microRNAs is critical to myriad aspects of eukaryotic development and physiology. Amidst an extensive regulatory web that is predicted to involve thousands of transcripts, emergent themes are now beginning to illustrate how microRNAs have been incorporated into diverse settings. These include potent inhibition of individual key targets, fine-tuning of target activity, the coordinated regulation of target batteries, and the reversibility of some aspects of microRNA-mediated repression
New way to control protein activity could lead to cancer therapies
sea-maid submitted, created time 2 months 2 weeks (www.sciencecentric.com)
Investigators at the Stanford University School of Medicine have found a way to quickly and reversibly fine-tune the activity of individual proteins in cells and living mammals, providing a powerful new laboratory tool for identifying-more precisely than ever before-the functions of different proteins.
The new technique also could help to speed the development of therapies in which cancer-fighting proteins are selectively delivered to tumors.
VGF, a New Player in Antidepressant Action?
jerry submitted, created time 7 months 3 weeks (stke.sciencemag.org)
This study links VGF to the antidepressant-like behavioral effects produced by antidepressant drugs and exercise.
VGF (not an acronym), a neuropeptide that has previously been shown to be involved in maintaining organismal energy balance, as well as in mediating hippocampal synaptic plasticity, may be involved in mediating antidepressant responses.
DNA scissors enhance gene therapy ...now available to all comers
jerry submitted, created time 5 months 2 weeks (sciencenow.sciencemag.org)
Imagine you're trying to find a cure for a disease, such as cystic fibrosis, which results from a single defective gene. Using traditional gene therapy, you'd infect the patient with a virus containing a good copy of the gene, hoping the DNA inserts into the person's genome in a spot that doesn't trigger cancer.
"There's got to be a better way," you tell yourself--and there is. About a decade ago, researchers began developing a new strategy that relies on proteins called zinc finger nucleases that bind to a very specific place on a chromosome
A better understanding of inherited breast cancer
sea-maid submitted, created time 2 months 1 week (www.sciencenews.org)
One of the molecular players in breast cancer arising from an inherited mutation has a surprising role in squelching tumors.
A protein that makes breast cancer spread
jane2007 submitted, created time 9 months 3 weeks (www.nature.com)
A protein that determines whether breast cancer will spread and become deadly has been found. Monitoring for the protein could help patients to know how dangerous their cancer is before it spreads elsewhere and help them to decide which treatment to chose.
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