61 Articles with the topic: Nephrology
Savient shares fall over gout drug safety concerns
sea-maid submitted, created time 2 months 1 week (biz.yahoo.com)
Shares of Savient Pharmaceuticals plunged Monday as Wall Street urged caution over the safety profile of the drug developer's candidate for gout treatment Puricase.
The stock plunged $8.51, or 73.5 percent, to $3.07. Earlier in the session, shares fell to $2.80, their lowest point in more than three years.
On Monday, Savient reported more late-stage study data on Puricase, reinforcing its effectiveness in prior results. If approved, the drug would be administered intravenously, with the goal of removing uric acid from the blood 
Singapore to examine kidney trading
sea-maid submitted, created time 5 months 2 weeks (news.yahoo.com)
Singapore is considering legalizing kidney trading to help meet demand for kidney transplants, the city-state's health minister said Monday
Warmer Temps, More Kidney Stones
sea-maid submitted, created time 5 months 3 weeks (www.time.com)
Kidney stones are already more common in the warmer Southern states than in the North.
Development of end stage renal disease following an acute cardiac event
sea-maid submitted, created time 6 months 2 weeks (www.nature.com)
The author determined the rate and risk factors for end-stage renal disease (ESRD) in consecutive patients discharged after a cardiac event in a large, unbiased Canadian cohort that receives universal health coverage.
Association of Oral Calcitriol with Improved Survival in Nondialyzed CKD
kavin submitted, created time 7 months 4 weeks (www.ncbi.nlm.nih.gov)
As we know, parenteral vitamin D is associated with improved survival among long-term hemodialysis patients. This paper tells us that association of calcitriol with improved survival was not statistically different across baseline parathyroid hormone levels. Calcitriol use was associated with a greater risk for hypercalcemia. In conclusion, oral calcitriol use is associated with lower mortality in nondialysis patients with CKD.
Organ trafficking cracked down upon in the Phillippines
Darkfrog submitted, created time 8 months 1 week (www.nytimes.com)
Poor Filipinos can make between $2000 and $10,000 (USD) by selling kidneys to sick foreigners. This has been illegal for many years, but a sixty percent increase in illegal kidney "donations" between 2004 and 2006 has sparked the government of the Phillippines to forbid foreign kidney donations entirely. With the exception of foreigners related by blood to Filipino citizens, this part of the Phillippines' medical tourism industry is to come to an end.
Clinical decision modeling system
biomedguru submitted, created time 1 year 2 months (www.biomedcentral.com)
This paper describes the world's first software designed specifically to facilitate integrative translational research. Researchers using the software will be able to plan effective integrative clinical trials that examine the utility of specific clinical workflows that integrate biomarkers, imaging, clinical and demographic data.
The software is available online here:
http://bioinformatics.pitt.edu/software/cdms/
Blood vessels grown from patient's own tissues used successfully in human patients
Darkfrog submitted, created time 1 year 2 months (www.nytimes.com)
Thirteen months and so far so good. Unlike earlier techniques used in Japan, which involved growing cells on a scaffold that slowly dissolved after implantation, scientists in Argentina grew whole stretches of blood vessel from the patients' own cells. The patients in question have damaged veins and arteries in their arms from regular dialysis.
This does not involve stem cells of any kind. A strip of skin is removed from the patient, but the fibroblast and endothelial cells are taken from the inside of the veins in that strip of skin
Elevation of Serum HSP90? Correlated with the Clinical Stage of Non-Small Cell Lung Cancer
MedUnion submitted, created time 1 year 3 months (www.mupnet.com)
AIM: The heat shock protein HSP90?, reportedly expressing in cytoplasm, had been recently detected in serum-free cultured medium (CM) from fibrosarcoma cells and breast adenocarcinoma cells. The present study was designed to investigate whether HSP90? could be found in the CM of lung cancer cell lines, and is a sensitive and specific serum biomarker for the diagnosis and progression of lung cancer
Normotensive Ischemic Acute Renal Failure
jiangyun submitted, created time 1 year 4 months (content.nejm.org)
Acute renal failure is defined as a rapid decrease in the glomerular filtration rate, occurring over a period of minutes to days. Because the rate of production of metabolic waste exceeds the rate of renal excretion in this circumstance, serum concentrations of markers of renal function, such as urea and creatinine, rise. The causes of acute renal failure are classically divided into three categories: prerenal, postrenal (or obstructive), and intrinsic. Prerenal azotemia is considered a functional response to renal hypoperfusion, in which renal structure and microstructure are preserved
Direct and indirect cellular effects of aspartame on the brain.
rmforall submitted, created time 1 year 4 months (www.ncbi.nlm.nih.gov)
Many informed experts, not controlled by vested interests, now publish detailed studies this year on the toxicity of aspartame, due to its components: methanol, aspartic acid, phenylalanine. The body always quickly converts methanol into formaldehyde.
Almost none of these mainstream studies are mentioned in mass print and broadcast media.
Here is their abstract. You can access the article for $ 30:
www.nature.com/ejcn/journal/vaop/ncurrent/abs/1602866a.html;jsessionid=DA855B80C66B37279C6D981F78BC3571
http://www.nature.com/ejcn/journal/vaop/ncurrent/pdf/1602866a
New blood test might offer early warning of deep belly fat
bianjie submitted, created time 1 year 5 months (www.eurekalert.org)
Measuring levels of a chemical found in blood offers the best indicator yet of the amount of fat surrounding abdominal organs, according to a new study of lean and obese individuals reported in the July issue of Cell Metabolism, a publication of Cell Press. The buildup of such "visceral fat" is of particular health concern as it has been linked to insulin resistance, type 2 diabetes, and heart disease risk.
A gene that protects from kidney disease
bianjie submitted, created time 1 year 6 months (www.eurekalert.org)
Researchers from the European Molecular Biology Laboratory (EMBL) and the University of Michigan have discovered a gene that protects us against a serious kidney disease. In the current online issue of Nature Genetics they report that mutations in the gene cause nephronopthisis (NPHP) in humans and mice. NPHP is a disease marked by kidney degeneration during childhood that leads to kidney failure requiring organ transplantation. The insights might help develop effective, noninvasive therapies.
Cancer risk in HIV, transplant patients
bianjie submitted, created time 1 year 6 months (www.unsw.edu.au)
HIV/AIDS and kidney transplant patients are at much greater risk of contracting 20 different types of cancer than the general population, according to research from the University of New South Wales. The land mark paper has been published in the Lancet.
Kidney Specialists Review Plans For Disaster Response
Dolly submitted, created time 1 year 6 months (www.sciencedaily.com)
Hurricane Katrina and other recent disasters have focused attention on the urgent need for planning to provide health services after natural disasters. Patients with end- stage renal failure pose special challenges, as any large-scale disaster is likely to interrupt the regular dialysis treatments they need to stay alive.
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