286 Articles with the topic: Neurological Disorders
Old gastrointestinal drug slows neurodegenerative diseases
sea-maid submitted, created time 1 day 10 hours (www.eurekalert.org)
Recent animal studies have shown that clioquinol – an eighty-year-old drug once used to treat diarrhea and other gastrointestinal disorders – can reverse the progression of Alzheimer's, Parkinson's and Huntington's diseases. Scientists, however, had a variety of theories to attempt to explain how a single compound could have such similar effects on three unrelated neurodegenerative disorders.
Researchers at McGill University have discovered a dramatic possible new answer: According to Dr 
Ohio State Studies Alzheimer's Vaccine Effectiveness
sea-maid submitted, created time 2 days 10 hours (media.www.thelantern.com)
Researchers at The Ohio State University Medical Center have begun studying the effects of a vaccine in slowing the onset of Alzheimer's disease or preventing it altogether.
Collagen VI may help protect the brain from Alzheimer's disease
piggy submitted, created time 2 days 20 hours (www.eurekalert.org)
Scientists from the Gladstone Institute of Neurological Disease (GIND), UCSF, and Stanford have discovered that a certain type of collagen, collagen VI, protects brain cells against amyloid-beta (Aβ) proteins, which are widely thought to cause Alzheimer's disease (AD). While the functions of collagens in cartilage and muscle are well established, before this study it was unknown that collagen VI is made by neurons in the brain and that it can fulfill important neuroprotective functions
Brain Birth Defects Successfully Reversed Through Stem Cell Therapy
piggy submitted, created time 1 week 2 days (www.sciencedaily.com)
Scientists at the Hebrew University of Jerusalem have succeeded in reversing brain birth defects in animal models, using stem cells to replace defective brain cells.
The work of Prof. Joseph Yanai and his associates at the Hebrew University-Hadassah Medical School was presented at the Tel Aviv Stem Cells Conference last spring and is expected to be presented and published nest year at the seventh annual meeting of the International Society for Stem Cell Research in Barcelona, Spain.
Involved in the project with Prof. Yanai are Prof
Brain starvation as we age appears to trigger Alzheimer's
sea-maid submitted, created time 1 week 4 days (esciencenews.com)
A slow, chronic starvation of the brain as we age appears to be one of the major triggers of a biochemical process that causes some forms of Alzheimer's disease. A new study from Northwestern University's Feinberg School of Medicine has found when the brain doesn't get enough sugar glucose -- as might occur when cardiovascular disease restricts blood flow in arteries to the brain -- a process is launched that ultimately produces the sticky clumps of protein that appear to be a cause of Alzheimer's.
Case Western Reserve finds mechanism underlying alt. splicing of premessenger RNA into messenger RNA
piggy submitted, created time 1 week 6 days (www.eurekalert.org)
An international research team led by Tim Nilsen, Ph.D., a professor of medicine and biochemistry and the director of the School of Medicine's Center for RNA Molecular Biology, has discovered an unexpected mechanism governing alternative splicing, the process by which single genes produce different proteins in different situations
MRI Brain Scans Accurate in Early Diagnosis of Alzheimer's Disease
piggy submitted, created time 2 weeks 2 days (www.sciencedaily.com)
JOURNAL: ScienceDaily
DESCRIPTION: MRI scans that detect shrinkage in specific regions of the mid-brain attacked by Alzheimer’s disease accurately diagnose the neurodegenerative disease, even before symptoms interfere with daily function, a study by the Florida Alzheimer’s Disease Research Center (ADRC) in Miami and Tampa found.
The study, reported earlier this month in the journal Neurology, adds to a growing body of evidence indicating MRI brain scans provide valuable diagnostic information about Alzheimer’s disease
Older antidepressants work for Parkinson patients
piggy submitted, created time 2 weeks 6 days (www.reuters.com)
People with Parkinson's disease who also suffer from depression may find they're helped more by an older class of antidepressants than newer types of medication, a small clinical trial sponsored by the National Institutes of Health suggests.
The study found that paroxetine (brand name, Paxil), a so-called SSRI antidepressant, appears to be less effective than the "tricyclic" antidepressant nortriptyline for treating depression in patients with Parkinson's disease.
"Depression in Parkinson's disease is underrecognized, underappreciated and undertreated," lead investigator Dr
piggy submitted, created time 1 month 3 days (www.sciencedaily.com)
Long thought of as mere bystanders, astrocytes are crucial for the survival and well-being of motor neurons, which control voluntary muscle movements. In fact, defective astrocytes can lay waste to motor neurons and are the main suspects in the muscle-wasting disease amyotrophic lateral sclerosis (ALS), commonly known as Lou Gherig's disease.
To get to the root of this complicated relationship, researchers from the Salk Institute for Biological Studies for the very first time established a human embryonic stem cell (hESC)-based system for modeling ALS
FDA: Epilepsy drug may be risky for Asians
piggy submitted, created time 1 month 1 week (www.fda.gov)
FDA is investigating new preliminary data regarding a potential increased risk of serious skin reactions including Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) from phenytoin therapy in Asian patients positive for a particular human leukocyte antigen (HLA) allele, HLA-B*1502. This allele occurs almost exclusively in patients with ancestry across broad areas of Asia, including Han Chinese, Filipinos, Malaysians, South Asian Indians, and Thais
Epilepsy drug may be risky for Asians
sea-maid submitted, created time 1 month 1 week (news.yahoo.com)
Treatment with certain epilepsy drugs may expose some Asian patients to serious skin reactions, federal health officials warned Monday.
The Food and Drug Administration said it is investigating whether medications like Dilantin, Phenytek and Cerebyx, which are used to control epileptic seizures, can lead to severe skin blisters and bleeding for some Asian patients.
Patients who test positive for a gene known as HLA-B1502 appear to be at increased risk of developing the skin problems, preliminary data indicate
How Red Wine Compounds Fight Alzheimer's Disease
piggy submitted, created time 1 month 2 weeks (www.sciencedaily.com)
Scientists call it the "French paradox" — a society that, despite consuming food high in cholesterol and saturated fats, has long had low death rates from heart disease. Research has suggested it is the red wine consumed with all that fatty food that may be beneficial — and not only for cardiovascular health but in warding off certain tumors and even Alzheimer's disease.
Now, Alzheimer's researchers at UCLA, in collaboration with Mt. Sinai School of Medicine in New York, have discovered how red wine may reduce the incidence of the disease. Reporting in the Nov
Enzyme Discovery May Lead to Better Heart and Stroke Treatments
piggy submitted, created time 1 month 2 weeks (www.sciencedaily.com)
A Queen's University study sheds new light on the way one of our cell enzymes, implicated in causing tissue damage after heart attacks and strokes, is normally kept under control.
Led by Biochemistry professor Peter Davies, the research team's discovery will be useful in developing new drug treatments that can aid recovery in stroke and heart disease, as well as lessen the effects of Alzheimer's and other neurologically degenerative diseases
Neurodegenerative disease: Giving survival a boost
sea-maid submitted, created time 1 month 2 weeks (www.nature.com)
Although it is the selective death of motor neurons that ultimately causes the symptoms of amyotrophic lateral sclerosis (ALS), the disease also renders other spinal cord cells, including astrocytes, dysfunctional. Maragakis and colleagues have now shown that the replacement of damaged astrocytes through precursor cell transplantation might be a useful therapeutic strategy for ALS.
The authors transplanted glial restricted precursors (GRPs) into the grey matter of the spinal cord in a transgenic rat model of ALS
Ginkgo Biloba Does Not Reduce Dementia Risk, Study Shows
piggy submitted, created time 1 month 2 weeks (www.sciencedaily.com)
The medicinal herb Ginkgo biloba does not reduce the risk of dementia or Alzheimer's disease development in either the healthy elderly or those with mild cognitive impairment, according to a large multicenter trial led by researchers at the University of Pittsburgh School of Medicine.
Findings from the Ginkgo Evaluation of Memory (GEM) Study, which is the first to have the necessary participant numbers and monitoring years to enable measurement of G. biloba's effectiveness and safety profile in dementia prevention, were just published in the Journal of the American Medical Association
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