22 Articles with the topic: Oncology
Scientists turbo-charge immune cells to fight cancer
piggy submitted, created time 2 weeks 3 days (news.yahoo.com)
Scientists in the United States have created super-charged immune cells that helped beat back cancer tumors in half of a small group of patients tested, according to a study released Sunday.
Adding an artificial receptor to T-lymphocyte immune cells boosted their ability to fight a deadly form of cancer called neuroblastoma, the researchers reported.
Neuroblastoma attacks the nervous system. While fairly rare, it accounts for seven percent of all childhood cancers, and fifteen percent of non-adult cancer deaths 
Broccoli May Lower Lung Cancer Risk in Smokers
piggy submitted, created time 2 days 12 hours (www.sciencedaily.com)
The cancer preventive properties of broccoli and other cruciferous vegetables appear to work specifically in smokers, according to data presented at the American Association for Cancer Research's Seventh Annual International Conference on Frontiers in Cancer Prevention Research.
Cruciferous vegetables have been shown to be protective in numerous studies, but this is the first comprehensive study that showed a protective benefit in smokers, specifically in former smokers, according to lead author Li Tang, Ph.D., a post-doctoral fellow at Roswell Park Cancer Institute
Tumorigenesis: Keeping a watchful eye
sea-maid submitted, created time 3 weeks 5 days (www.nature.com)
Disruptions in the delicate balance between keratinocyte proliferation and differentiation can contribute towards the development of squamous cell carcinoma (SCC) of the skin — a common human malignancy. It has been proposed that innate surveillants, molecules that promote terminal keratinocyte differentiation, exist in the skin to prevent carcinogenesis, but the conclusive identification of such proteins has not yet been achieved
Ark floats gene therapy's boat, for now
sea-maid submitted, created time 3 weeks 5 days (www.nature.com)
In August, gene therapy's turbulent ride through the clinical rapids took a new twist as Ark Therapeutics released positive top-line results from a phase 3 trial of its adenoviral gene therapy Cerepro (sitimagene ceradenovec) for malignant brain tumors. Although the news boosted the London-based firm's shares, the course to market authorization and registration remains strewn with uncertainty—as Introgen, of Austin, Texas, found, to its cost, when the U.S
Statins Lower Blood Marker for Prostate Cancer
piggy submitted, created time 2 weeks 5 days (www.healthday.com)
THURSDAY, Oct. 30 (HealthDay News) -- A new study shows that men who take cholesterol-lowering drugs called statins have lower blood levels of prostate-specific antigen (PSA), a biomarker for prostate cancer risk.
That drop in PSA levels doesn't necessarily mean the drugs protect against disease, however, researchers say.
But it's possible that statins may offer some protection against the disease, said Dr. Robert Hamilton, one author of the report in the Oct. 28 issue of the Journal of the National Cancer Institute
Gene Variations Alter Risk of Esophageal Cancer
piggy submitted, created time 2 weeks 1 day (www.sciencedaily.com)
ScienceDaily (Nov. 6, 2008) — Variations in a common gene pathway may affect esophageal cancer risk, a dangerous and rapidly increasing type of cancer, according to research by scientists at The University of Texas M. D. Anderson Cancer Center.
Results of the study, which is the first to look at the association between variations in genes related to microRNAs (miRNAs) and esophageal cancer, are published in the November issue of Cancer Prevention Research, a journal of the American Association of Cancer Research.
How Eating Red Meat Can Spur Cancer Progression: New Mechanism Identified
piggy submitted, created time 1 week 9 hours (www.sciencedaily.com)
Researchers at the University of California, San Diego School of Medicine, led by Ajit Varki, M.D., have shown a new mechanism for how human consumption of red meat and milk products could contribute to the increased risk of cancerous tumors.
Their findings, which suggest that inflammation resulting from a molecule introduced through consumption of these foods could promote tumor growth, are published online this week in advance of print publication in the Proceedings of the National Academy of Sciences (PNAS)
Tumor Secrets Written in Blood
piggy submitted, created time 3 days 9 hours (sciencenow.sciencemag.org)
Doctors may soon be able to use blood tests rather than invasive biopsies to figure out what type of brain tumors their patients have. The findings, which come thanks to new insights about how tumor cells communicate with their environment, may also bring physicians closer to the goal of more personalized medicine.
Cells are chatty, constantly exchanging proteins or electrical signals with their neighbors. For example, tumor cells can signal nearby blood vessels to grow in their direction, thereby facilitating tumor growth
The von Hippel–Lindau tumor suppressor protein: O2 sensing and cancer
sea-maid submitted, created time 4 weeks 1 day (www.nature.com)
The von Hippel–Lindau disease is caused by inactivating germline mutations of the VHL tumor suppressor gene and is associated with an increased risk of a variety of tumours in an allele-specific manner. The role of the heterodimeric transcription factor hypoxia-inducible factor (HIF) in the pathogenesis of VHL-defective tumors has been more firmly established during the past five years
New way to control protein activity could lead to cancer therapies
sea-maid submitted, created time 4 weeks 1 day (www.sciencecentric.com)
Investigators at the Stanford University School of Medicine have found a way to quickly and reversibly fine-tune the activity of individual proteins in cells and living mammals, providing a powerful new laboratory tool for identifying-more precisely than ever before-the functions of different proteins.
The new technique also could help to speed the development of therapies in which cancer-fighting proteins are selectively delivered to tumors.
Derailed endocytosis: an emerging feature of cancer
sea-maid submitted, created time 2 weeks 6 days (www.nature.com)
Once engaged by soluble or matrix-anchored ligands, cell surface proteins are commonly sorted to lysosomal degradation through several endocytic pathways. Defective vesicular trafficking of growth factor receptors, as well as unbalanced recycling of integrin- and cadherin-based adhesion complexes, has emerged in the past five years as a multifaceted hallmark of malignant cells
Industry shifts focus to immunology and cancer
sea-maid submitted, created time 1 week 4 days (www.nature.com)
Economic factors, including competition from generic drugs, is hitting even the big pharmaceutical companies hard, reports Nature. In 2010, Pfizer's Lipitor enters the public domain. For these reasons, the larger companies are narrowing the focus of their research, hitting fewer diseases. They're also working on fewer primary care drugs and more drugs that would be prescribed by specialists, such as cancer drugs.
"When Wyeth Pharmaceuticals announced last week that it would cut some of its research and development (R&D) programs in women's health, the decision seemed counterintuitive
DNA: Too Much--or Too Little--Can Be a Bad Thing
piggy submitted, created time 4 days 23 hours (sciencenow.sciencemag.org)
There's more variety to DNA than you might think: Deletions or additions of genetic material between individuals, called copy number variations (CNVs), are a common source of genetic diversity. Now, preliminary work reported here today at the American Society of Human Genetics meeting suggests that men who have more CNVs than average may be more likely to sire children with the eye cancer retinoblastoma
Men who take aspirin have significantly lower PSA levels
sea-maid submitted, created time 4 days 9 hours (www.genengnews.com)
The use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) is significantly associated with lower PSA levels, especially among men with prostate cancer, say researchers at Vanderbilt University.
Calcium May Only Protect Against Colorectal Cancer in Presence of Magnesium
sea-maid submitted, created time 3 days 9 hours (www.sciencedaily.com)
High magnesium intake has been associated with low risk of colorectal cancer. Americans have similar average magnesium intake as East Asian populations. If that were all that were involved, observers might expect both groups to have similar risk for colorectal cancer
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