411 Articles with the topic: Pharmacology & Drug Discovery
Neurodegenerative disease: Giving survival a boost
sea-maid submitted, created time 2 days 20 minutes (www.nature.com)
Although it is the selective death of motor neurons that ultimately causes the symptoms of amyotrophic lateral sclerosis (ALS), the disease also renders other spinal cord cells, including astrocytes, dysfunctional. Maragakis and colleagues have now shown that the replacement of damaged astrocytes through precursor cell transplantation might be a useful therapeutic strategy for ALS.
The authors transplanted glial restricted precursors (GRPs) into the grey matter of the spinal cord in a transgenic rat model of ALS 
Ginkgo Biloba Does Not Reduce Dementia Risk, Study Shows
piggy submitted, created time 2 days 1 hour (www.sciencedaily.com)
The medicinal herb Ginkgo biloba does not reduce the risk of dementia or Alzheimer's disease development in either the healthy elderly or those with mild cognitive impairment, according to a large multicenter trial led by researchers at the University of Pittsburgh School of Medicine.
Findings from the Ginkgo Evaluation of Memory (GEM) Study, which is the first to have the necessary participant numbers and monitoring years to enable measurement of G. biloba's effectiveness and safety profile in dementia prevention, were just published in the Journal of the American Medical Association
Calcium May Only Protect Against Colorectal Cancer in Presence of Magnesium
sea-maid submitted, created time 2 days 22 hours (www.sciencedaily.com)
High magnesium intake has been associated with low risk of colorectal cancer. Americans have similar average magnesium intake as East Asian populations. If that were all that were involved, observers might expect both groups to have similar risk for colorectal cancer
Men who take aspirin have significantly lower PSA levels
sea-maid submitted, created time 3 days 21 hours (www.genengnews.com)
The use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) is significantly associated with lower PSA levels, especially among men with prostate cancer, say researchers at Vanderbilt University.
New Therapy Could Transform Arthritis Treatment
sea-maid submitted, created time 5 days 23 hours (health.msn.com)
New understanding about how to control autoimmune responses offers promise in efforts to develop treatments for rheumatoid arthritis (RA), British researchers say.
Merck vaccine protects men from wart virus, too
sea-maid submitted, created time 1 week 1 day (www.reuters.com)
A vaccine designed to protect women and girls from cervical cancer caused by a wart virus may protect men, too, maker Merck and Co reported on Thursday
Bone marrow transplant suppresses AIDS in patient
sea-maid submitted, created time 1 week 1 day (www.reuters.com)
A bone marrow transplant using stem cells from a donor with natural genetic resistance to the AIDS virus has left an HIV patient free of infection for nearly two years, German researchers.
The patient, an American living in Berlin, was infected with the human immunodeficiency virus that causes AIDS and also had leukemia. The best treatment for the leukemia was a bone marrow transplant, which takes the stem cells from a healthy donor's immune system to replace the patient's cancer-ridden cells.
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Bayer drug delays MS in half of patients-MRI study
sea-maid submitted, created time 1 week 1 day (www.alertnet.org)
A long-term study of brain scans in multiple sclerosis patients showed only about half of the patients who took the drug interferon beta 1-b got a long-lasting benefit, U.S. researchers said on Monday.
Patients in the small, three-year study were treated with the Bayer drug, which is sold under the trade name Betaseron in the United States or Betaferon elsewhere.
The drug is designed to reduce the number of disease flareups.
Multiple sclerosis occurs when the immune system attacks the myelin sheath protecting nerve cells. It affects 2
Industry shifts focus to immunology and cancer
sea-maid submitted, created time 1 week 3 days (www.nature.com)
Economic factors, including competition from generic drugs, is hitting even the big pharmaceutical companies hard, reports Nature. In 2010, Pfizer's Lipitor enters the public domain. For these reasons, the larger companies are narrowing the focus of their research, hitting fewer diseases. They're also working on fewer primary care drugs and more drugs that would be prescribed by specialists, such as cancer drugs.
"When Wyeth Pharmaceuticals announced last week that it would cut some of its research and development (R&D) programs in women's health, the decision seemed counterintuitive
Nanoparticle Research Aids Drug Development
piggy submitted, created time 1 week 3 days (www.sciencedaily.com)
Scientists at the University of Liverpool have developed a new technology which can dramatically improve the effectiveness of antibacterial treatments.
Soluble drugs, soluble antibiotics in this case, that can dissolve in water tend to be more effective at lower doses, but these are rare. Insoluble drugs are more common, but they have to be administered at higher doses so that the patient will feel the same effect
Antibacterial drugs: New paths to beating bacteria
sea-maid submitted, created time 2 weeks 4 days (www.nature.com)
The need for new drugs to combat multidrug-resistant bacteria remains pressing. Now, two recent papers published in Science describe novel agents that target different mechanisms to currently approved antibacterials, which may help tackle this challenge.
The first study, by Haydon and colleagues, set out to target bacterial cell division. FtsZ is an essential bacterial protein that undergoes GTP-dependent polymerization to form the Z ring — the site of cell division — promoting the sequential recruitment of additional proteins that are vital to the process
Neurodegenerative disease: Are amyloids the culprit?
sea-maid submitted, created time 2 weeks 4 days (www.nature.com)
Amyloid- (A) peptides are thought to have a key role in the neurotoxicity and cognitive decline that occur in Alzheimer's disease (AD), but there have recently been several disappointments with late-stage clinical trials of agents that target A. Two recent papers in Nature Medicine shed light on the mechanisms through which A could contribute to the aetiology of AD and identify novel targets for drug development, as well as compounds that modulate these targets.
One of the ways in which A is thought to contribute to the pathogenesis of AD is by disrupting mitochondrial function
sea-maid submitted, created time 2 weeks 4 days (www.nature.com)
New studies have affirmed the complexity of genetic changes in solid tumors, but also revealed commonalities in the associated pathways, suggesting that a pathway-oriented perspective could aid cancer drug discovery and therapy.
Gene Scan of Alzheimer's Families Identifies Four New Suspect Genes
sea-maid submitted, created time 2 weeks 4 days (thepasskey.info)
The first family-based genome-wide association study in Alzheimer's disease has identified the sites of four novel genes that may significantly influence risk for the most common late-onset form of the devastating neurological disorder. In their report in the November 7 American Journal of Human Genetics, a team led by researchers from the MassGeneral Institute for Neurodegenerative Disease (MGH-MIND) describes how newly available technology is improving understanding of genetic mechanisms underlying the disease.
Statins Lower Blood Marker for Prostate Cancer
piggy submitted, created time 2 weeks 5 days (www.healthday.com)
THURSDAY, Oct. 30 (HealthDay News) -- A new study shows that men who take cholesterol-lowering drugs called statins have lower blood levels of prostate-specific antigen (PSA), a biomarker for prostate cancer risk.
That drop in PSA levels doesn't necessarily mean the drugs protect against disease, however, researchers say.
But it's possible that statins may offer some protection against the disease, said Dr. Robert Hamilton, one author of the report in the Oct. 28 issue of the Journal of the National Cancer Institute
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