45 Articles with the topic: Rheumatology & Clinical Immunology
Gene linked to lupus might explain gender difference in disease risk
piggy submitted, created time 11 months 1 week (www.eurekalert.org)
In an international human genetic study, researchers at UT Southwestern Medical Center have identified a gene linked to the autoimmune disease lupus, and its location on the X chromosome might help explain why females are ten times more susceptible to the disease than males.
Identifying this gene, IRAK1, as a disease gene may also have therapeutic implications, said Dr. Chandra Mohan, professor of internal medicine and senior author of the study. "Our work also shows that blocking IRAK1 action shuts down lupus in an animal model 
Scientists grow diabetes drug in tobacco plants
sea-maid submitted, created time 11 months 2 weeks (www.reuters.com)
Scientists have found a healthy use for tobacco after breeding genetically modified plants containing interleukin 10, which could interfere with the progression of type 1 diabetes and other autoimmune conditions.
The process of growing medicines through genetically modified plants, called molecular farming, is projected to be cheaper than traditional factory methods. The article also quotes University of Verona scientist Mario Pezzotti as saying that they may also be cheaper than cell cultures--the current standard for antibody medicines
Potential New Antibody Treatment for Autoimmune Diseases
piggy submitted, created time 1 year 1 month (www.sciencedaily.com)
Scientists at UCSF have discovered an abnormality in a patient's immune system that may lead to safer therapies for autoimmune diseases such as rheumatoid arthritis and colitis, as well as potential new ways to treat transplant rejection.
The research identified antibodies from a woman’s immune system that prevent infection-fighting T cells from moving through her blood stream and entering her body’s organs to attack invaders such as bacteria or viruses
Scientists Identify New Congenital Neutropenia Syndrome and Causative Gene Mutation
piggy submitted, created time 1 year 2 months (www.nih.gov)
A team of scientists has discovered a new syndrome associated with severe congenital neutropenia (SCN), a rare disorder in which children lack sufficient infection-fighting white cells, and identified the genetic cause of the syndrome: mutations in the gene Glucose-6-phosphatase, catalytic subunit 3 (G6PC3). The findings, which are published in the Jan
Rheumatoid Arthritis Breakthrough
piggy submitted, created time 1 year 3 months (www.sciencedaily.com)
Rheumatoid arthritis is a painful, inflammatory type of arthritis that occurs when the body's immune system attacks itself. A new article reports a breakthrough in the understanding of how autoimmune responses can be controlled, offering a promising new strategy for therapy development for rheumatoid arthritis.
Normally, immune cells develop to recognise foreign material – antigens; including bacteria - so that they can activate a response against them. Immune cells that would respond to 'self' and therefore attack the body's own cells are usually destroyed during development
New MRI Scan Detects Early Arthritis
kavin submitted, created time 1 year 6 months (www.webmd.com)
A new MRI test promises to detect osteoarthritis early, when treatments are most helpful.
The technique also detects spinal disc degeneration, report NYU researchers Alexej Jerschow, PhD, and Ravinder R. Regatte, PhD, at the 236th annual meeting of the American Chemical Society, held Aug. 17-21 in Philadelphia.
"Our methods have the potential of providing early warning signs for cartilage disorders like osteoarthritis, thus potentially avoiding surgery and physical therapy later on," Jerschow says in a news release
kavin submitted, created time 1 year 8 months (content.nejm.org)
Much has been learned about the potential of the immune system to control cancer and the various ways that immunotherapy can boost the potential of the immune system for the benefit of the patient. This knowledge has stimulated the invention of many new therapeutic antibodies, cell-based treatments, and vaccines, which are starting to be used in clinical practice, either alone or in various combinations. These new therapies are expected to result in improved cancer treatment and, eventually, the prevention of cancer.
Genetic interaction with smoking in arthritis
jerry submitted, created time 1 year 10 months (arthritis-research.com)
Analysis of data from a study of American nurses confirms the PTPN22 polymorphism is a strong risk factor for rheumatoid arthritis, and that its presence interacts multiplicatively with heavy smoking.
Clearing the Air over Asbestos
davidd submitted, created time 1 year 10 months (sciencenow.sciencemag.org)
Researchers may have cracked the mystery of how asbestos causes life-threatening lung damage and cancer. A new study shows that the material triggers key immune system proteins that set off chronic inflammation. As a result, a commonly used arthritis drug might ward off the lung problems induced by exposure.
jane2007 submitted, created time 2 years 3 months (www.nature.com)
A clinical trial of gene therapy in which a woman died this summer is due to recommence.
The article give us a explanation why the trial restart and the views of people. I think it good for us understand the gene theraphy.
Good news: Study Finds Gene Therapy Did Not Kill Patient!
Eric wu submitted, created time 2 years 3 months (sciencenow.sciencemag.org)
Federal regulators have given a green light to a gene-therapy arthritis trial that was halted last summer after a patient died. New tests indicate that the therapy played no role in the death. The decision comes as a relief to gene-therapy researchers who had worried about a potential new setback for their field.
Clinical decision modeling system
biomedguru submitted, created time 2 years 4 months (www.biomedcentral.com)
This paper describes the world's first software designed specifically to facilitate integrative translational research. Researchers using the software will be able to plan effective integrative clinical trials that examine the utility of specific clinical workflows that integrate biomarkers, imaging, clinical and demographic data.
The software is available online here:
http://bioinformatics.pitt.edu/software/cdms/
Direct and indirect cellular effects of aspartame on the brain.
rmforall submitted, created time 2 years 6 months (www.ncbi.nlm.nih.gov)
Many informed experts, not controlled by vested interests, now publish detailed studies this year on the toxicity of aspartame, due to its components: methanol, aspartic acid, phenylalanine. The body always quickly converts methanol into formaldehyde.
Almost none of these mainstream studies are mentioned in mass print and broadcast media.
Here is their abstract. You can access the article for $ 30:
www.nature.com/ejcn/journal/vaop/ncurrent/abs/1602866a.html;jsessionid=DA855B80C66B37279C6D981F78BC3571
http://www.nature.com/ejcn/journal/vaop/ncurrent/pdf/1602866a
red monkey submitted, created time 2 years 8 months (www.nature.com)
Parathyroid hormone peptides are an exciting new therapeutic option for patients with osteoporosis. In this Practice Point Commentary, Dr Compston discusses the recent findings of the meta-analysis by Vestergaard et al., highlighting the issues related to the use of parathyroid hormone treatment in clinical practice. Topics of discussion include the effect of parathyroid hormone peptides on risk of hip fracture, the optimal duration of treatment, and the role of combination therapy with anti-resorptive agents.
Biological markers in osteoarthritis
red monkey submitted, created time 2 years 8 months (www.nature.com)
Clinical and radiographic changes are currently used to diagnose osteoarthritis, but these changes occur late in the course of disease, and show poor sensitivity for monitoring progression. The use of biological markers of joint metabolism might potentially improve prediction of disease progression, as outlined in this article by Pierre D Delmas and Jean-Charles Rousseau.
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