41 Articles with the topic: Rheumatology & Clinical Immunology
Rheumatoid Arthritis Breakthrough
piggy submitted, created time 1 week 21 hours (www.sciencedaily.com)
Rheumatoid arthritis is a painful, inflammatory type of arthritis that occurs when the body's immune system attacks itself. A new article reports a breakthrough in the understanding of how autoimmune responses can be controlled, offering a promising new strategy for therapy development for rheumatoid arthritis.
Normally, immune cells develop to recognise foreign material – antigens; including bacteria - so that they can activate a response against them. Immune cells that would respond to 'self' and therefore attack the body's own cells are usually destroyed during development 
New MRI Scan Detects Early Arthritis
kavin submitted, created time 2 months 2 weeks (www.webmd.com)
A new MRI test promises to detect osteoarthritis early, when treatments are most helpful.
The technique also detects spinal disc degeneration, report NYU researchers Alexej Jerschow, PhD, and Ravinder R. Regatte, PhD, at the 236th annual meeting of the American Chemical Society, held Aug. 17-21 in Philadelphia.
"Our methods have the potential of providing early warning signs for cartilage disorders like osteoarthritis, thus potentially avoiding surgery and physical therapy later on," Jerschow says in a news release
kavin submitted, created time 4 months 3 weeks (content.nejm.org)
Much has been learned about the potential of the immune system to control cancer and the various ways that immunotherapy can boost the potential of the immune system for the benefit of the patient. This knowledge has stimulated the invention of many new therapeutic antibodies, cell-based treatments, and vaccines, which are starting to be used in clinical practice, either alone or in various combinations. These new therapies are expected to result in improved cancer treatment and, eventually, the prevention of cancer.
Genetic interaction with smoking in arthritis
jerry submitted, created time 6 months 1 week (arthritis-research.com)
Analysis of data from a study of American nurses confirms the PTPN22 polymorphism is a strong risk factor for rheumatoid arthritis, and that its presence interacts multiplicatively with heavy smoking.
Clearing the Air over Asbestos
davidd submitted, created time 7 months 1 week (sciencenow.sciencemag.org)
Researchers may have cracked the mystery of how asbestos causes life-threatening lung damage and cancer. A new study shows that the material triggers key immune system proteins that set off chronic inflammation. As a result, a commonly used arthritis drug might ward off the lung problems induced by exposure.
jane2007 submitted, created time 11 months 3 weeks (www.nature.com)
A clinical trial of gene therapy in which a woman died this summer is due to recommence.
The article give us a explanation why the trial restart and the views of people. I think it good for us understand the gene theraphy.
Good news: Study Finds Gene Therapy Did Not Kill Patient!
Eric wu submitted, created time 11 months 3 weeks (sciencenow.sciencemag.org)
Federal regulators have given a green light to a gene-therapy arthritis trial that was halted last summer after a patient died. New tests indicate that the therapy played no role in the death. The decision comes as a relief to gene-therapy researchers who had worried about a potential new setback for their field.
Clinical decision modeling system
biomedguru submitted, created time 1 year 2 weeks (www.biomedcentral.com)
This paper describes the world's first software designed specifically to facilitate integrative translational research. Researchers using the software will be able to plan effective integrative clinical trials that examine the utility of specific clinical workflows that integrate biomarkers, imaging, clinical and demographic data.
The software is available online here:
http://bioinformatics.pitt.edu/software/cdms/
Direct and indirect cellular effects of aspartame on the brain.
rmforall submitted, created time 1 year 3 months (www.ncbi.nlm.nih.gov)
Many informed experts, not controlled by vested interests, now publish detailed studies this year on the toxicity of aspartame, due to its components: methanol, aspartic acid, phenylalanine. The body always quickly converts methanol into formaldehyde.
Almost none of these mainstream studies are mentioned in mass print and broadcast media.
Here is their abstract. You can access the article for $ 30:
www.nature.com/ejcn/journal/vaop/ncurrent/abs/1602866a.html;jsessionid=DA855B80C66B37279C6D981F78BC3571
http://www.nature.com/ejcn/journal/vaop/ncurrent/pdf/1602866a
red monkey submitted, created time 1 year 4 months (www.nature.com)
Parathyroid hormone peptides are an exciting new therapeutic option for patients with osteoporosis. In this Practice Point Commentary, Dr Compston discusses the recent findings of the meta-analysis by Vestergaard et al., highlighting the issues related to the use of parathyroid hormone treatment in clinical practice. Topics of discussion include the effect of parathyroid hormone peptides on risk of hip fracture, the optimal duration of treatment, and the role of combination therapy with anti-resorptive agents.
Biological markers in osteoarthritis
red monkey submitted, created time 1 year 4 months (www.nature.com)
Clinical and radiographic changes are currently used to diagnose osteoarthritis, but these changes occur late in the course of disease, and show poor sensitivity for monitoring progression. The use of biological markers of joint metabolism might potentially improve prediction of disease progression, as outlined in this article by Pierre D Delmas and Jean-Charles Rousseau.
Why Does Rheumatoid Arthritis Involve the Joints?
diggman submitted, created time 1 year 5 months (content.nejm.org)
A long-standing question in rheumatology is why inflammatory arthritides such as rheumatoid arthritis involve the joints. Many studies have addressed this question; a recent article by Lee et al.1 provides a new answer that is both obvious and intriguing. Rheumatoid arthritis affects the joints because of the essential role of the synovium in regulating inflammation.
athena submitted, created time 1 year 5 months (www.jci.org)
"Patients with Omenn syndrome (OS) have hypomorphic RAG mutations and develop varying manifestations of severe combined immunodeficiency. It is not known which symptoms are caused directly by the RAG mutations and which depend on other polymorphic genes. Our current understanding of OS is limited by the lack of an animal model. In the present study, we identified a C57BL/10 mouse with a spontaneous mutation in, and reduced activity of, RAG1
Experimental gene therapy 'abolishes' arthritis pain and lessens joint damage
alpha submitted, created time 1 year 5 months (www.biologynews.net)
Early-stage research has found that a new gene therapy can nearly eliminate arthritis pain, and significantly reduce long-term damage to the affected joints, according to a study published today in the journal Arthritis and Rheumatism. While the study was done in mice, they are the first genetically engineered to develop osteoarthritis like humans, with the same genetic predisposition that makes some more likely to develop the disease, the authors said. If all goes well with a follow-up study currently underway, researchers will apply to the U.S
Regulation of AID expression in the immune response
badboy submitted, created time 1 year 5 months (www.jem.org)
"The B cell–specific enzyme activation-induced cytidine deaminase (AID) has been shown to be essential for isotype switching and affinity maturation of antibody genes during the immune response. Conversely, AID activity has also been linked to autoimmunity and tumorigenesis. Determining how AID expression is regulated in vivo is therefore central to understanding its role in health and disease."
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